AutismKB 2.0

Annotation Detail for MCOLN3


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Basic Information Top
Gene Symbol:MCOLN3 ( FLJ11006,FLJ36629,MGC71509,TRP-ML3,TRPML3 )
Gene Full Name: mucolipin 3
Band: 1p22.3
Quick LinksEntrez ID:55283; OMIM: 607400; Uniprot ID:MCLN3_HUMAN; ENSEMBL ID: ENSG00000055732; HGNC ID: 13358
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MCOLN3 mRNAdecreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MCOLN3 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of MCOLN3 mRNAincreases expression 20458559
D016572 Cyclosporine Cyclosporine results in increased expression of MCOLN3 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3611798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.741440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.883581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8812907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8815553829 14691202 15073043 16217749 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.457505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4512371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.869022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.8619486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.358156756 2524372 18759878 11298694 14531868 8970840 12868966 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.046679447 18289764 9653073 16192314 1440618 7440962 9022650 18692083 9328219 6482804 18648102 11289319 8291058
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.743581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7412903497
MESH:D005234 Fatty Liver arsenic trioxide 9.2015073043
MESH:D005234 Fatty Liver Cyclosporine 9.2019224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005355 Fibrosis Cyclosporine 3.7012639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.548314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.436582329
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4312371664
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916968895 19850784 16467208 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4617712046 12018890 16823087 16330433 19035177 19225113 19642359 19075265 12712474 17217047 11468182 15748426 17107899 15622746 9834237 17869043 16112521 12679006 17649720 15336539 16891316 16331271 15213294 11161223 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.429327722 15034207
MESH:D008113 Liver Neoplasms Aflatoxin B1 5.082125692 18177683 15890375 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 5.0814682389
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 11.241399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.248603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.2420377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6119825857 11798837
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3815949261 19417148 14977855 19549372 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6519348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.066679447
MESH:D009436 Neural Tube Defects arsenic trioxide 8.0610525206
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.816482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.191399818 6587162 7505956 6582329 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.1919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.508074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.5012845720 20435036 12973940 11780464
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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