AutismKB 2.0

Annotation Detail for RHOT1


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Basic Information Top
Gene Symbol:RHOT1 ( ARHT1,FLJ11040,FLJ12633,MIRO-1 )
Gene Full Name: ras homolog gene family, member T1
Band: 17q11.2
Quick LinksEntrez ID:55288; OMIM: NA; Uniprot ID:MIRO1_HUMAN; ENSEMBL ID: ENSG00000126858; HGNC ID: 21168
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RHOT1 mRNAincreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of RHOT1 mRNAincreases expression 20458559
C006253 pirinixic acid pirinixic acid results in increased expression of RHOT1 mRNAincreases expression 18301758
17426115
D014501 Uranium Uranium affects the expression of RHOT1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of RHOT1 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3511798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.2716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.2719483382
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.157296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1515553829 11135700 16217749 14691202 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.7219486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.7219176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5015213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.288970840 12868966 11298694 14531868 18759878 8156756 2524372 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.893621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.039653073 1440618 18692083 7440962 9022650 9328219 6482804 8291058 18648102 6679447 18289764 16192314 11289319
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.713581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7112903497
MESH:D005234 Fatty Liver arsenic trioxide 8.9815073043
MESH:D005234 Fatty Liver pirinixic acid 8.9820131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 18467677 19772884 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D007938 Leukemia arsenic trioxide 2.9815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1820471514 19850784 16467208 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4319642359 15336539 19225113 12679006 11161223 17217047 17649720 15748426 17869043 12018890 15213294 15622746 19035177 16331271 19075265 12712474 16823087 16330433 11468182 9834237 16112521 17712046 16891316 16966277 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.409327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8414682389
MESH:D008113 Liver Neoplasms pirinixic acid 4.8416377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.65598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6520377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3515949261 19417148 19549372 14977855 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3216105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.986679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9810525206
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4919769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.076587162 3712494 7505956 6582329 1399818
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.468074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4611780464 12973940 12845720 20435036
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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