AutismKB 2.0

Annotation Detail for BOLA2


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Basic Information Top
Gene Symbol:BOLA2 ( BOLA2A,My016 )
Gene Full Name: bolA homolog 2 (E. coli)
Band: 16p11.2
Quick LinksEntrez ID:552900; OMIM: 613182; Uniprot ID:BOLA2_HUMAN; ENSEMBL ID: ENSG00000183336; HGNC ID: 29488
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of BOLA2 mRNAaffects expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of BOLA2 mRNAincreases expression 19774075
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of BOLA2 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of BOLA2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2018057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.2018651412 19698954
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.3219483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1719103187 19189212 18855134 17261762 18629630 20390343 19244106 20859285 18351453 20135344 16202921 18815881 19142967 19084267 19155303 19288272 16273361 19221464 19410462 19115204 18425577 19200415 21138602 11161223 19059307 15565566 16873071 17893378 17242785 21152245 19066611 20544844 16818667 19189210 19289846 19011961 17049068 15668708 18997820 18821012 19487384 17440819 20065188 20005174 18984771
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.127296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0019225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.7218974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.8519486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.8515861022 16919318 17110522 17681005 17333356 16105132 11677210
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3518759878 11298694 14531868 8970840 12868966 2524372 11906362 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.3118289764 7440962 18648102 6679447 11289319 16192314 9022650 9328219 8291058 1440618 6482804 18692083 9653073
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.3115265979 18218290
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.6812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.6819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2920544844 17893378 19155303 16202921
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005234 Fatty Liver Amiodarone 15.7414986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.7415345470
MESH:D005234 Fatty Liver Tamoxifen 15.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006529 Hepatomegaly Amiodarone 4.3115265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.309751232 8137927
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 5.0818020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.556582329
MESH:D007680 Kidney Neoplasms Tamoxifen 8.5518625569
MESH:D008064 Lipidoses Amiodarone 8.8517567588 15342952
MESH:D008064 Lipidoses Tamoxifen 8.8517567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3316684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.751399818 3712494 598648 6587162
MESH:D008133 Long QT Syndrome Amiodarone 3.8915350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.2018516814
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8614580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D009181 Mycoses Amiodarone 5.6217974566 12754197
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.133581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219189210 19200415 19196722
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.814026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9712490602 11597910 12832656
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.7218724381
MESH:D013088 Spermatocele Ethinyl Estradiol 14.1116709447
MESH:D013088 Spermatocele Tamoxifen 14.1116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D013276 Stomach Ulcer Amiodarone 3.7418087811
MESH:D013610 Tachycardia Amiodarone 4.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7019225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013959 Thyroid Diseases Amiodarone 5.4819731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.193712494 6582329 1399818 6587162 7505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.4219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.8217467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.468074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.468653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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