AutismKB 2.0

Annotation Detail for PPP3CA


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Basic Information Top
Gene Symbol:PPP3CA ( CALN,CALNA,CALNA1,CCN1,CNA1,PPP2B )
Gene Full Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Band: 4q24
Quick LinksEntrez ID:5530; OMIM: 114105; Uniprot ID:PP2BA_HUMAN; ENSEMBL ID: ENSG00000138814; HGNC ID: 9314
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
hsa04114Oocyte meiosis
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Opioid Signalling
Pathway IDPathway Name
200130C-MYB transcription factor network
Pathway IDPathway Name
P00053T cell activation
P00010B cell activation
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPP3CA mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PPP3CA mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PPP3CA mRNAaffects expression 21346803
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of PPP3CA mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP3CA mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPP3CA mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPP3CA mRNAdecreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPP3CA mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PPP3CA mRNAdecreases expression 12419474
D002211 Capsaicin PPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]affects reaction|decreases reaction|increases secretion 17590514
D002220 Carbamazepine Carbamazepine results in decreased expression of PPP3CA mRNAdecreases expression 14642444
D002220 Carbamazepine Carbamazepine results in decreased expression of PPP3CA proteindecreases expression 14642444
D003024 Clozapine [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA proteinaffects binding|decreases activity|increases expression 16033416
D003024 Clozapine Clozapine results in decreased expression of PPP3CA mRNAdecreases expression 16033416
D003024 Clozapine Clozapine results in decreased expression of PPP3CA proteindecreases expression 16033416
D003024 Clozapine Clozapine results in increased expression of PPP3CA mRNAincreases expression 12437575
C017160 cypermethrin [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargindecreases activity|decreases response to substance 10898953
D003847 Deoxyglucose PPP3CA protein results in decreased susceptibility to Deoxyglucosedecreases response to substance 10679475
D002117 Calcitriol Calcitriol results in increased expression of PPP3CA mRNAincreases expression 16002434
D004112 Dimercaprol Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA]decreases expression|decreases reaction 16377760
D004958 Estradiol Estradiol results in decreased expression of PPP3CA mRNAdecreases expression 20068009
D000431 Ethanol ALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein]decreases reaction|increases expression 19332462
D000431 Ethanol Ethanol results in increased expression of PPP3CA proteinincreases expression 19332462
D005419 Flavonoids Flavonoids results in increased expression of PPP3CA mRNAincreases expression 18035473
D005472 Fluorouracil [Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNAaffects cotreatment|increases expression 16391804
D005472 Fluorouracil Fluorouracil results in increased expression of PPP3CA proteinincreases expression 16803524
15585135
D005472 Fluorouracil PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D006220 Haloperidol [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA proteinaffects binding|decreases activity|increases expression 16033416
D006220 Haloperidol Haloperidol results in decreased expression of PPP3CA mRNAdecreases expression 16033416
D006220 Haloperidol Haloperidol results in decreased expression of PPP3CA proteindecreases expression 16033416
C051890 irinotecan [Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNAaffects cotreatment|increases expression 16391804
C051890 irinotecan irinotecan analog results in decreased expression of PPP3CA mRNAdecreases expression 18927307
C051890 irinotecan PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]affects cotreatment|affects response to substance 18927307
D007657 Ketone Bodies Ketone Bodies results in increased expression of PPP3CA mRNAincreases expression 16807920
D008713 Methimazole Methimazole results in decreased expression of PPP3CA mRNAdecreases expression 17403546
D008727 Methotrexate PPP3CA protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D009151 Mustard Gas Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA]decreases expression|decreases reaction 16377760
D009151 Mustard Gas Mustard Gas results in decreased expression of PPP3CA mRNAdecreases expression 16377760
D009151 Mustard Gas Mustard Gas affects the expression of PPP3CA mRNAaffects expression 15651846
C027793 mustard oil PPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]]affects reaction|decreases reaction|increases secretion 17590514
C494474 perchlorate perchlorate results in decreased expression of PPP3CA mRNAdecreases expression 17403546
D010634 Phenobarbital Phenobarbital results in decreased expression of PPP3CA mRNAdecreases expression 19363144
C045950 propiconazole propiconazole results in decreased expression of PPP3CA mRNAdecreases expression 19363144
D011441 Propylthiouracil Propylthiouracil results in decreased expression of PPP3CA mRNAdecreases expression 17403546
D018967 Risperidone [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA proteinaffects binding|decreases activity|increases expression 16033416
D018967 Risperidone Risperidone results in decreased expression of PPP3CA mRNAdecreases expression 16033416
D018967 Risperidone Risperidone results in decreased expression of PPP3CA proteindecreases expression 16033416
D019311 Staurosporine Staurosporine results in increased cleavage of PPP3CA proteinincreases cleavage 10898953
D019311 Staurosporine PPP3CA protein results in decreased susceptibility to Staurosporinedecreases response to substance 10679475
D016559 Tacrolimus [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargindecreases activity|decreases response to substance 10898953
D019284 Thapsigargin [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargindecreases activity|decreases response to substance 10898953
D019284 Thapsigargin [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargindecreases activity|decreases response to substance 10898953
D019284 Thapsigargin Thapsigargin promotes the reaction [PPP3CA protein results in decreased phosphorylation of NFATC1 protein]decreases phosphorylation|increases reaction 10898953
D019284 Thapsigargin Thapsigargin results in increased cleavage of PPP3CA proteinincreases cleavage 10898953
D024505 Tocopherols Tocopherols results in increased expression of PPP3CA mRNAincreases expression 17654050
D014212 Tretinoin Tretinoin results in decreased expression of PPP3CA mRNAdecreases expression 16140955
D014415 Tunicamycin Tunicamycin results in increased expression of PPP3CA mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of PPP3CA mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 27.927525203
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 27.9218926900
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 27.928986270
MESH:D000014 Abnormalities, Drug-Induced Ethanol 27.9218926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 27.9212039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 27.926195326
MESH:D000138 Acidosis Ammonium Chloride 9.1218287403
MESH:D000138 Acidosis Ethanol 9.1211192467
MESH:D058186 Acute Kidney Injury Capsaicin 4.1818460982
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.3920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.3911473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.3917638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 5.793712494
MESH:D000236 Adenoma Benzo(a)pyrene 5.796695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 3.5717620307
MESH:D000380 Agranulocytosis Clozapine 4.6616160616 14617031 12649775
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.5216487989
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9015451040 15451039
MESH:D000505 Alopecia Capsaicin 8.5117569567
MESH:D000505 Alopecia Tretinoin 8.5115955085
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.8410965797
MESH:D000740 Anemia Fluorouracil 3.3617963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 3.4310982225
MESH:D000853 Anophthalmos Ethanol 4.4215513904
MESH:D001008 Anxiety Disorders Ethanol 7.9511141031
MESH:D001008 Anxiety Disorders vinclozolin 7.9519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6819183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.8216412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.5017286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5016292516
MESH:D020817 Asperger Syndrome Risperidone 5.1516401163
MESH:D001249 Asthma Mustard Gas 4.5210378619
MESH:D001249 Asthma Tretinoin 4.5216456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.5118349709
MESH:D001321 Autistic Disorder Acetaminophen 2.3218445737
MESH:D001321 Autistic Disorder Haloperidol 2.3219368416 18080171
MESH:D001321 Autistic Disorder Risperidone 2.3218080171 16379507 16730335 16239862 19154706 19013209 17019624 19368416 16601648 15994720 17929164 16948927 19232924 18026891 18349709 18775368 15492353 17069546 18278980 15930063 15543515
MESH:D001471 Barrett Esophagus Tretinoin 4.0216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.601440618 11289319
MESH:D001714 Bipolar Disorder Carbamazepine 7.3617594078 20046352
MESH:D001714 Bipolar Disorder Risperidone 7.3618278980 19154706
MESH:D001768 Blister Mustard Gas 4.7519167455
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 8.1819483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.1816206674 16197459
MESH:D001919 Bradycardia Capsaicin 4.6518207255
MESH:D002545 Brain Ischemia Capsaicin 4.5719211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.4720146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 3.4711237771
MESH:D001943 Breast Neoplasms Deoxyglucose 3.4718985042
MESH:D001943 Breast Neoplasms Estradiol 3.4719861407 14630087 12948864 17018787 16675129 18497071 17261762 17289903
MESH:D001943 Breast Neoplasms Fluorouracil 3.4716110121 15136595 18608205 16557594 18357371 19217205 16595493
MESH:D001943 Breast Neoplasms Methotrexate 3.4716978400
MESH:D001943 Breast Neoplasms Tretinoin 3.4716166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1816813970
MESH:D002056 Burns Ethanol 4.2616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0616111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.2516051944
MESH:D002277 Carcinoma Fluorouracil 3.2517121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7416168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 15.5416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 15.547296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.543084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.5416924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 15.5418788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.5416332177 16799960 17045692 18930000 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.541701930 17173139 6705139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.541917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.837296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.8318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.7020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 9.7011237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.7016280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.7016051514 16096774
MESH:D006332 Cardiomegaly Ethanol 3.2119332462
MESH:D002318 Cardiovascular Diseases Tacrolimus 4.3317703430
MESH:D002375 Catalepsy Haloperidol 4.501977408 15215559
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 10.9514694615
MESH:D002386 Cataract Acetaminophen 10.9510977129
MESH:D002386 Cataract Tretinoin 10.9517460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.537505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.5320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.5318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.854080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1816129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.8519486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 4.7416461808
MESH:D002971 Cleft Lip Ethanol 3.3715513904
MESH:D002972 Cleft Palate Ethanol 5.5515513904
MESH:D002972 Cleft Palate Tretinoin 5.559407595
MESH:D003072 Cognition Disorders Clozapine 4.5717123785
MESH:D003092 Colitis Tretinoin 3.3117035595
MESH:D003110 Colonic Neoplasms Fluorouracil 3.6717287894 17725105 17169374 15001691 17016597 16510598 16340194 17172411 17018589 18772588
MESH:D003110 Colonic Neoplasms irinotecan 3.6717725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6216331619 18448328 17094418 16282729 17016601 16391804 17594712 20501625 18288408 18802399 18949393 16524972 15289873 15148649 14970324 17695437 17255274 16303861 18509181 17401013 17454858 18383874
MESH:D015179 Colorectal Neoplasms irinotecan 2.6218509181 16391804 17454858 18259882 17159606 15273666 16303861
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 3.8215095906
MESH:D003371 Cough Capsaicin 4.7610350223
MESH:D019465 Craniofacial Abnormalities Carbamazepine 5.109014606
MESH:D019465 Craniofacial Abnormalities Ethanol 5.1019302082 15451040 10194807 11873399 11198716 15451039 15513904
MESH:D019465 Craniofacial Abnormalities Methotrexate 5.1012039119 9562676
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.109211117 17551590 9224671 8800419 9142499 10589399 9125849 16925845 14991402 9664655
MESH:D003456 Cryptorchidism vinclozolin 3.9514966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6218551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.8919747007
MESH:D007644 Darier Disease Fluorouracil 4.3816733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.2120210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 10.2120210726
MESH:D003704 Dementia Haloperidol 9.3411575062
MESH:D003704 Dementia Risperidone 9.3411575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.4314531868 11298694 11906362 8970840 12868966 2524372 8156756 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.122952479 3621924
MESH:D003882 Dermatomyositis Methotrexate 4.7420191521
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.8716402076
MESH:D003928 Diabetic Nephropathies Estradiol 3.0719279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 13.0615331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 13.0616379507
MESH:D053207 Diurnal Enuresis Risperidone 6.2617822346
MESH:D004314 Down Syndrome Risperidone 4.7718349709
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.0511748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.1616538176 15057820 20216337 16538175
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 13.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 13.4918648102 18692083 11289319 9328219 7440962 6679447 9653073 8291058 9022650 18289764 16192314 6482804 1440618
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 13.4921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.4916227642 11739529 16109766 2444490 15968718 12540782 16485898 11743745 14986274 19923254 19164858 10663392 19370779 12392966 16781746 11529661 11461765 12153990 12705907 10774834 11834606 10915739 19416960 15619225 18071297 19739265 19085960 14550746 17906064 19420014 17522070 11287661 12594235 18713872 16081117 16393943 14725611 17562736 11421492 12958197 16177239
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 13.4917465707
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.4911566570
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6819426721
MESH:D004362 Drug Toxicity Carbamazepine 4.1620216337
MESH:D004381 Duodenal Ulcer Capsaicin 8.7511535926 10671773
MESH:D004381 Duodenal Ulcer Tacrolimus 8.7517202747
MESH:D050171 Dyslipidemias Clozapine 3.8916402076
MESH:D004417 Dyspnea cypermethrin 4.9816487989
MESH:D004421 Dystonia Phenobarbital 3.631851702
MESH:D004487 Edema Mustard Gas 6.3911428647 11402378 11428631 9260866
MESH:D004487 Edema Staurosporine 6.398273558
MESH:D004489 Edema, Cardiac Tretinoin 4.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.3815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 8.3817654737
MESH:D016889 Endometrial Neoplasms Estradiol 6.5218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.5216569247
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.8716538176 19915237 18855540 16415921 20485159
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 9.8617275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.863659116
MESH:D004828 Epilepsies, Partial Carbamazepine 8.9915008574 17116037 16628512
MESH:D004828 Epilepsies, Partial Phenobarbital 8.993922381 11558140
MESH:D004827 Epilepsy Carbamazepine 6.3317465707 19620853 821787 19439326 20417680 9014606 17178248 19700373 7988514 18234410
MESH:D004827 Epilepsy Phenobarbital 6.3320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.206401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 10.377750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 9.523659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.523659116
MESH:D004890 Erythema Mustard Gas 4.759357497
MESH:D004916 Erythromelalgia Carbamazepine 5.3119549232
MESH:D004935 Esophageal Diseases Capsaicin 5.3019566590
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 12.543581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.5420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.5416530937
MESH:D004938 Esophageal Neoplasms Ethanol 12.5416704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.5416481741 16337965 17638652 15173087 16785472
MESH:D005076 Exanthema Carbamazepine 5.0620485159
MESH:D005124 Eye Abnormalities Tretinoin 3.2716938888 9664655
MESH:D005234 Fatty Liver Ethanol 3.3818620774 16409862 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2517920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8910194807 15513904 16946407 15451040
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.606705139
MESH:D005355 Fibrosis Tretinoin 3.1217994277
MESH:D005756 Gastritis Acetaminophen 9.7516983495
MESH:D005756 Gastritis Ethanol 9.7515046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5316973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8916417039
MESH:D005909 Glioblastoma Capsaicin 6.6318405923
MESH:D005909 Glioblastoma Tretinoin 6.6317312396
MESH:D005910 Glioma Fluorouracil 2.7016145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 10.237505956
MESH:D006042 Goiter perchlorate 10.2318801409
MESH:D006086 Graft vs Host Disease Methotrexate 11.1516518429
MESH:D006086 Graft vs Host Disease Tacrolimus 11.1516376943
MESH:D006130 Growth Disorders Tacrolimus 4.6511041285
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.8718337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.8716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7416084493
MESH:D006356 Heartburn Capsaicin 5.3019566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9120471113
MESH:D006330 Heart Defects, Congenital Tretinoin 5.919664655 14991402
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.526705139
MESH:D006505 Hepatitis cypermethrin 8.5216487989
MESH:D006529 Hepatomegaly Phenobarbital 7.7416109766
MESH:D006529 Hepatomegaly propiconazole 7.7417178688 17178689
MESH:D006558 Herpes Genitalis Estradiol 4.6215709030
MESH:D019584 Hot Flashes Estradiol 3.3417088409
MESH:D006930 Hyperalgesia Acetaminophen 16.0916870215
MESH:D006930 Hyperalgesia Capsaicin 16.0917043245 17434803
MESH:D006930 Hyperalgesia Ethanol 16.0918783367
MESH:D006930 Hyperalgesia Tretinoin 16.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1716778211
MESH:D006943 Hyperglycemia Risperidone 4.8118278980
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.3910459572
MESH:D006948 Hyperkinesis Clozapine 4.5016046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.8015034207
MESH:D006965 Hyperplasia Carbamazepine 9.8018773962
MESH:D006980 Hyperthyroidism Methimazole 5.2314678291
MESH:C537153 Hypomagnesemia primary Tacrolimus 5.7511041285
MESH:D007022 Hypotension Tacrolimus 4.7511041285
MESH:D007037 Hypothyroidism Methimazole 10.6318031379
MESH:D007037 Hypothyroidism Propylthiouracil 10.638137927 18031379
MESH:D007248 Infertility, Male vinclozolin 2.7716467254
MESH:D007249 Inflammation Capsaicin 10.3616956363
MESH:D007249 Inflammation Flavonoids 10.3617296493
MESH:D007249 Inflammation Mustard Gas 10.368975870 11428631 9260866 11402378 11428620 16001271 17524151 11428647 9357497
MESH:D007249 Inflammation mustard oil 10.3616793879
MESH:D007299 Insect Bites and Stings cypermethrin 5.5615189238
MESH:D007333 Insulin Resistance Estradiol 2.7016627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.3717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.609022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 9.1215513904
MESH:D007569 Jaw Abnormalities Tretinoin 9.1215992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 8.8412587719 15629191
MESH:D007674 Kidney Diseases Estradiol 8.8415618244
MESH:D007674 Kidney Diseases Tacrolimus 8.8411041285
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 15.0716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 15.076582329
MESH:D007680 Kidney Neoplasms Estradiol 15.0715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 15.0716985049
MESH:D007805 Language Development Disorders Methotrexate 4.739562676
MESH:D007859 Learning Disorders Ethanol 3.8215451040
MESH:D007938 Leukemia Tretinoin 2.5617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8817339181 17301526 17107899 19029980 17712046 17368321 17294898 16788101 16891316 16140955 19035177 12679006 19642359 19225113 17649720 19075265 17217047 16935935 16331271 17506722 9834237 15748426 16766008 16823087 17361223
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3216417039
MESH:D017880 Limb Deformities, Congenital Ethanol 7.3417676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.349224671
MESH:D008064 Lipidoses Clozapine 3.6717567588
MESH:D008103 Liver Cirrhosis Ethanol 9.8715289165
MESH:D008103 Liver Cirrhosis Methotrexate 9.8714986274
MESH:D008103 Liver Cirrhosis Phenobarbital 9.8721047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6918295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.949327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.2818166357
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.2816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 11.2919460945 12587719 19784758 16611625 12969438 11587558 19014921 16610002
MESH:D008107 Liver Diseases Capsaicin 11.2916956363
MESH:D008107 Liver Diseases cypermethrin 11.2915991261
MESH:D008107 Liver Diseases Phenobarbital 11.2919363144
MESH:D008107 Liver Diseases propiconazole 11.2919363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2617347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8816871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 9.3920195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 9.3917045692 16603448 15113037 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 9.3919812893 8742319 19073162 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms propiconazole 9.3919028983
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.52598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.5217172636 6150874 18308698 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental propiconazole 8.5217178689
MESH:D008171 Lung Diseases Mustard Gas 3.1818161513 18702808
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.6118516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.2017053015 18816296 20064080 18520028 20869020 18569708 6695378 20464547 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 3.2015246190
MESH:D008175 Lung Neoplasms Mustard Gas 3.203148597 8781369
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3815086387
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.4516628512
MESH:D008223 Lymphoma Methotrexate 3.6617352296
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6316891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 5.6317927505
MESH:D020149 Manganese Poisoning Estradiol 4.0719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6217453147
MESH:D008545 Melanoma Tretinoin 1.8916752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1719513568
MESH:D008569 Memory Disorders Ethanol 3.8015451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.0316940565
MESH:D001523 Mental Disorders Clozapine 11.1216856516
MESH:D001523 Mental Disorders Haloperidol 11.1216856516
MESH:D001523 Mental Disorders Risperidone 11.1216856516 16596465
MESH:D008607 Mental Retardation Carbamazepine 6.199014606
MESH:D008607 Mental Retardation Risperidone 6.1918349709
MESH:D008654 Mesothelioma Tocopherols 3.9415878867
MESH:D024821 Metabolic Syndrome X Clozapine 9.0819142101
MESH:D024821 Metabolic Syndrome X Risperidone 9.0819142101
MESH:D019964 Mood Disorders Risperidone 5.4317019624
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.5016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.5018986760 16757204
MESH:D052016 Mucositis irinotecan 11.2417159606
MESH:D052016 Mucositis Methotrexate 11.2417488658
MESH:D009101 Multiple Myeloma Capsaicin 3.8717505005
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8417596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9716810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0717484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.0620399394
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.343581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.3418259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.0611141357
MESH:D009369 Neoplasms Fluorouracil 7.0618239605 16928823 18600527
MESH:D009369 Neoplasms Tretinoin 7.0616946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3317289903
MESH:D009421 Nervous System Malformations Carbamazepine 14.3316990009
MESH:D009421 Nervous System Malformations Estradiol 14.3316427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 14.339125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.336679447
MESH:D009436 Neural Tube Defects Tretinoin 6.339142499
MESH:D009447 Neuroblastoma irinotecan 3.268761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6818514411
MESH:D019636 Neurodegenerative Diseases Tacrolimus 7.6815081597
MESH:D017599 Neuroectodermal Tumors irinotecan 4.328761367
MESH:D020078 Neurogenic Inflammation Capsaicin 4.7117961222
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1616436463
MESH:D009503 Neutropenia Mustard Gas 3.607688884 16761898
MESH:D053206 Nocturnal Enuresis Risperidone 5.9117822346
MESH:D009765 Obesity Capsaicin 4.9019056576
MESH:D009765 Obesity Clozapine 4.9019142110 18515891
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 13.1216049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 13.126482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 13.1214694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.603988306
MESH:D010018 Osteomalacia Carbamazepine 10.7417016548
MESH:D010018 Osteomalacia Phenobarbital 10.7417016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.3419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.3416936753
MESH:D010146 Pain Acetaminophen 13.5016870215
MESH:D010146 Pain Capsaicin 13.5019081190 17084039 17043245 16996476 18987195 17434803
MESH:D010146 Pain Carbamazepine 13.5015215642
MESH:D010146 Pain Tretinoin 13.5016870215
MESH:D010190 Pancreatic Neoplasms Ethanol 11.0412384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.0416929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.0416965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.0415976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.097296757
MESH:D010267 Parapsoriasis Carbamazepine 5.3016538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.5217679678 17145499
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 11.616228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 11.6111550810
MESH:D011041 Poisoning Mustard Gas 3.4315727166
MESH:D011230 Precancerous Conditions Phenobarbital 3.282563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.769014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 8.769014606
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.7618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5318220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5220887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8912479363 15754350 16289102 18247401 16644109
MESH:D011471 Prostatic Neoplasms Deoxyglucose 1.8918985042
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Tocopherols 1.8912504091
MESH:D011472 Prostatitis vinclozolin 4.5318629315
MESH:D011507 Proteinuria Tretinoin 3.2316636307
MESH:D011537 Pruritus Mustard Gas 3.6918058305
MESH:D019310 Pseudolymphoma Carbamazepine 11.209591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 11.2012752131
MESH:D011565 Psoriasis Methotrexate 3.2817410198
MESH:D011595 Psychomotor Agitation Haloperidol 4.5611575062
MESH:D011618 Psychotic Disorders Clozapine 8.1815331141
MESH:D011618 Psychotic Disorders Haloperidol 8.1811575062
MESH:D011625 Pterygium Tretinoin 4.3816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7717720292 17894541 10334151 17266442 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6716160472 18286688 15538739 18722050
MESH:D051437 Renal Insufficiency Methotrexate 4.3217352296
MESH:D015427 Reperfusion Injury Capsaicin 3.7618460982 19211983
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.073692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7316283617 16116481
MESH:D012559 Schizophrenia Clozapine 5.4716141801 20452607 18855531 11763009 20107430 17726453 17667964 20521326 18806925 20521320 20168265 17123785 11151749 19369910 20580759
MESH:D012559 Schizophrenia Haloperidol 5.4719369910 20107430 18513383 1830565
MESH:D012559 Schizophrenia Risperidone 5.4720107430 19154706 18278980
MESH:D012640 Seizures 2,4-dinitrotoluene 15.6818551238
MESH:D012640 Seizures Carbamazepine 15.689844417 15946322 16876388 16938433 16180713 19414003 9046859
MESH:D012640 Seizures Deoxyglucose 15.6817978042
MESH:D012640 Seizures Ethanol 15.689754883
MESH:D012640 Seizures Phenobarbital 15.683137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.416407741
MESH:D012871 Skin Diseases Mustard Gas 2.6016961503 15451306 12880345
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3010029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.308532709
MESH:D012878 Skin Neoplasms Tretinoin 8.3016467112
MESH:D012893 Sleep Disorders Carbamazepine 10.0619414003
MESH:D012893 Sleep Disorders Risperidone 10.0618278980
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 4.8119694795 16415921 16538176 15057820 18855540 19915237 20485159
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.882093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 5.8818456281
MESH:D013274 Stomach Neoplasms Fluorouracil 5.8816424979 18567086 18396642 17172411 16951190 19084572 17522103 17498489 19015929 15786421
MESH:D013274 Stomach Neoplasms irinotecan 5.8815723263
MESH:D013274 Stomach Neoplasms Tretinoin 5.8817261132
MESH:D013276 Stomach Ulcer Ethanol 3.1816755016 11906479 9211565 17918041 9562338 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.909754883
MESH:D013576 Syndactyly Methotrexate 4.659562676
MESH:D017180 Tachycardia, Ventricular Haloperidol 9.7020210726
MESH:D017180 Tachycardia, Ventricular Risperidone 9.7020210726
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.3117997062
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 14.597505956 6582329 1399818 6587162 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.591399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 14.5915710170
MESH:D013964 Thyroid Neoplasms Tretinoin 14.5916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.2719048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.6616280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.6616051514
MESH:D005879 Tourette Syndrome Risperidone 5.5419154706
MESH:D014376 Tuberculosis Tretinoin 2.9716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.2616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.268074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.2617053015
MESH:D014570 Urologic Diseases cypermethrin 5.4516487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9110091137
MESH:D014581 Urticaria Acetaminophen 2.6110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.2816803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.2816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2016752155
MESH:D014820 Vitiligo Tretinoin 3.6716761959
MESH:D015430 Weight Gain Clozapine 9.2420564506 20521320 16402076 20107430 16141801 17502770
MESH:D015430 Weight Gain Risperidone 9.2416379507 20564506
MESH:D015431 Weight Loss Clozapine 4.6717933447
MESH:D009396 Wilms Tumor Tretinoin 3.6316287080
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04210 Apoptosis
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04020 Calcium signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04380 Osteoclast differentiation
KEGG:04660 T cell receptor signaling pathway
KEGG:05152 Tuberculosis
KEGG:04370 VEGF signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33678
    • No data
    No data
    Releated drug ID Related drug Name
    PA449396dopamine
    PA164743471adenosine triphosphate
    PA449167cyclosporine
    PA451578tacrolimus
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB08231 - MYRISTIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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