AutismKB 2.0

Annotation Detail for PPP4C


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Basic Information Top
Gene Symbol:PPP4C ( PP4,PP4C,PPH3,PPP4,PPX )
Gene Full Name: protein phosphatase 4, catalytic subunit
Band: 16p11.2
Quick LinksEntrez ID:5531; OMIM: 602035; Uniprot ID:PP4C_HUMAN; ENSEMBL ID: ENSG00000149923; HGNC ID: 9319
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PPP4C mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PPP4C mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PPP4C mRNAaffects cotreatment|decreases expression 20360939
D009151 Mustard Gas Mustard Gas results in increased expression of PPP4C mRNAincreases expression 15674844
D019319 Okadaic Acid Okadaic Acid binds to and results in decreased activity of PPP4C proteinaffects binding|decreases activity 15767308
D012643 Selenium Selenium results in increased expression of PPP4C mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of PPP4C mRNAincreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of PPP4C mRNAaffects expression 17440010
D014810 Vitamin E Vitamin E results in increased expression of PPP4C mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000236 Adenoma Diethylnitrosamine 2.966695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1816434500 19061943 18056438 17162532 19052882 17620307
MESH:D001249 Asthma Mustard Gas 2.7610378619
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2910378619 17687719
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8618971187 19335982 18788625 20727157 18494052 16502159 18665156 18506893 20524982 3581430 18056438 19052882 16698587 19171122 10737359 19208518 16681979 20214788 11831363 21159647 16540662 19701751 17428255 17978847 19383236 20007298 20432363 16288022 20512989 19539802 19107877 19822196 16807293 3084413 20935162 18393292 20514400 17761372 16830150 16569478 16878318 16779866 19519916 17138121 19418558 16328049 17162532 17173139 10672840 16935385 19394651 18210153 20084675 18691550 17055752 18785209 20101231 18978308 19919837
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9921159647 17174075 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6219107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6215131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6215131321
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Mustard Gas 3.5111428631 11402378 9260866 11428647
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3921071580 20387270
MESH:D005909 Glioblastoma Okadaic Acid 4.7517312396
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.0617440010
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D007249 Inflammation Diethylnitrosamine 5.5618785209
MESH:D007249 Inflammation Mustard Gas 5.5611428631 9357497 11428620 8975870 9260866 16001271 17524151 11428647 11402378
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7810783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.8315369732
MESH:D007674 Kidney Diseases Vitamin E 6.8312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1216766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318665156 18407596 18522880 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3021278145 20583210 19254457 19551842 19638242 15885732 20101389 19833225 19690152 19255062 12112319 18978307 15175105 20434301 18648771 19256749 20137499 19090486 19499222 21071580 19426721 10737359 20452335 20492335 19812893 21167192 18977376 19642983 19427195 20405173 18644402 20118626 19294768 9163691 16942905 20501860 12771043 2422723 21047994 19996281 18754104 19850985 19073162 2862719
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7519009564 16842330 18775883 18282651 3124819 18164116 18544905 18093689 19126423 19004024 18079962 19539802 19519916 17854601 17174075 18253720 18308698 17942915 16267830 9362446 2563599 21159647
MESH:D008171 Lung Diseases Mustard Gas 7.9918161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.9916863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6221163286 20512841 6695378 20970405
MESH:D008175 Lung Neoplasms Mustard Gas 3.623148597 8781369
MESH:D008175 Lung Neoplasms Vitamin E 3.6211062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.643581430 9029167
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009503 Neutropenia Mustard Gas 4.1916761898 7688884
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3018760546
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D011537 Pruritus Mustard Gas 4.3818058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9917620002 17894541 17720292 10334151 17266442
MESH:D012871 Skin Diseases Mustard Gas 5.1812880345 16961503 15451306
MESH:D012871 Skin Diseases Vitamin E 5.1818709164
MESH:D012878 Skin Neoplasms Okadaic Acid 4.3112628509
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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