AutismKB 2.0

Annotation Detail for C14orf106


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Basic Information Top
Gene Symbol:C14orf106 ( FLJ11186,HSA242977,KIAA1903,KNL2,MIS18BP1 )
Gene Full Name: chromosome 14 open reading frame 106
Band: 14q21.2
Quick LinksEntrez ID:55320; OMIM: NA; Uniprot ID:KNL2_HUMAN; ENSEMBL ID: ENSG00000129534; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Chromosome Maintenance
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MIS18BP1 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MIS18BP1 mRNAdecreases expression 20382639
19150397
20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of MIS18BP1 mRNAincreases expression 17484886
C017947 sodium arsenite sodium arsenite results in decreased expression of MIS18BP1 mRNAdecreases expression 17998272
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6316712894 17306315
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3415721981 16192424 18705752 16124888 16227642 16050911 15700767 3786805 15673190 10355542 16011737 16097048
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.9012907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.9018788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.9017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6120889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.6119524636 20056578
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.127440962 15998439 21278145 11566570 6884620 3786805 9327722 19085960 16227642 10092053 17522070 15027814 10915739 16177239 7179309 3732212 4309450 19336974 2869522 6623471 7120509 15968718
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5912795759 61145 12631006 15959796 16045604 17595544 19224547 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 4.0118705752
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019900420 19110552
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007248 Infertility, Male sodium arsenite 3.2415346721 12646999
MESH:D007674 Kidney Diseases sodium arsenite 3.0020008137
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0016239168 11408273 17334410 11903743 17174718 16943688 17157831 21278145 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7512609069 14716496 18418968 17714472 18481824 15673190 11481614 15338365 15876570 16248980 18279442 17823541 10355542 12666154 12445421 15370692 17631135 14512876 15052691 17708605 18339082 18472094 18317297 12898905 17525996 15818738 15959796 17557913 17766677 17761835 18277467 18205269 17900296 17698563 18420326 16136751 18395095 15931870 18263696 14620537 15650968 12632514 17976157 18210741 18166357 18054572 18187930 17869086 18472332 18006644 17565644 15925388 16116963 12389079 17640975 18395914 18156304 12546737 17721639 17805973 18429990 12445418 16192424 17922224 16027843 13678700 15123356 17481882 15057751 12649538 12741479 18412020 14716833 18251166 16097048 18376398 16033810 16638106 12958196 15730626 14748882 16015684 16011737 12632512 15893842 12667390 20821823 17944888 18705752 15996030 15362042 12586293 14724832
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515720792 17285989 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0816899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.2215890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.2219294768
MESH:D008113 Liver Neoplasms sodium arsenite 8.2215276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.768603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.7615583823 12014681
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6314755239
MESH:D008175 Lung Neoplasms sodium arsenite 2.6319931552 16712894 15276417 17306315 17077188
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D009369 Neoplasms sodium arsenite 2.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5315276417 17306315
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6317306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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