Annotation Detail for AGPAT5
Basic Information
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| Gene Symbol: | AGPAT5 ( 1AGPAT5,LPAATE ) |
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| Gene Full Name: | 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) |
|---|
| Band: | 8p23.1 |
|---|
| Quick Links | Entrez ID:55326; OMIM: NA; Uniprot ID:PLCE_HUMAN; ENSEMBL ID: ENSG00000155189; HGNC ID: 20886 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| PWY4FS-8 | phosphatidylglycerol biosynthesis II (non-plastidic) |
| TRIGLSYN-PWY | triacylglycerol biosynthesis |
| PWY-5667 | CDP-diacylglycerol biosynthesis I |
| Pathway ID | Pathway Name |
|---|
| Metabolism of lipids and lipoproteins |
| Desease Name |
|---|
| CHEMDEPENDENCY |
| smoking cessation |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of AGPAT5 mRNA | affects expression | 20382639
|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AGPAT5 mRNA | decreases expression | 19150397
|
| C006780 |
bisphenol A |
bisphenol A results in decreased expression of AGPAT5 mRNA | decreases expression | 20678512
|
| D016572 |
Cyclosporine |
Cyclosporine results in increased expression of AGPAT5 mRNA | increases expression | 20106945
|
| D008942 |
Mitoxantrone |
AGPAT5 protein affects the susceptibility to Mitoxantrone | affects response to substance | 16217747
|
| D012402 |
Rotenone |
Rotenone results in decreased expression of AGPAT5 mRNA | decreases expression | 19013527
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D001862 |
Bone Resorption |
|
bisphenol A |
4.24 | 11985600 |
| MESH:D001943 |
Breast Neoplasms |
|
bisphenol A |
2.43 | 17123778 |
| MESH:D002278 |
Carcinoma in Situ |
|
bisphenol A |
5.53 | 17123778 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7.35 | 20889678 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
7.35 | 12371664 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
3.17 | 19486331 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
2.14 | 20426865 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
3.23 | 19224547 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.62 | 12168785 12639820 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.76 | 8708960 |
| MESH:D006331 |
Heart Diseases |
|
Mitoxantrone |
4.39 | 16019553 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
4.96 | 15720958 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.20 | 10903974 |
| MESH:D007333 |
Insulin Resistance |
|
bisphenol A |
3.50 | 16393666 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.05 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.52 | 18776723 10903974 8314463 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.04 | 12371664 |
| MESH:D015451 |
Leukemia, Lymphocytic, Chronic, B-Cell |
|
Mitoxantrone |
3.91 | 18172266 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.40 | 16801185 |
| MESH:D009369 |
Neoplasms |
|
Mitoxantrone |
3.56 | 16640825 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.05 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.61 | 18481113 19348381 |
| MESH:D009410 |
Nerve Degeneration |
|
Rotenone |
4.15 | 18619942 15790535 17356569 |
| MESH:D009421 |
Nervous System Malformations |
|
bisphenol A |
4.41 | 11399458 16427766 |
| MESH:D010049 |
Ovarian Diseases |
|
bisphenol A |
5.53 | 11985600 |
| MESH:D010300 |
Parkinson Disease |
|
Rotenone |
3.08 | 19232380 18191903 11445065 15451049 11535288 19114014 18619942 16140633 16412576 |
| MESH:D020734 |
Parkinsonian Disorders |
|
Rotenone |
4.42 | 15795934 15574749 15927086 18197244 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.55 | 12371664 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
bisphenol A |
4.49 | 10548101 |
| MESH:D019048 |
Prostatic Intraepithelial Neoplasia |
|
bisphenol A |
4.58 | 20887781 |
| MESH:D011471 |
Prostatic Neoplasms |
|
bisphenol A |
3.35 | 16740699 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.32 | 16882103 |
| MESH:D011629 |
Puberty, Precocious |
|
bisphenol A |
5.33 | 10548101 |
| MESH:D019966 |
Substance-Related Disorders |
|
bisphenol A |
4.52 | 16045194 16684133 |
| MESH:D014591 |
Uterine Diseases |
|
bisphenol A |
5.62 | 14652134 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.59 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.05 | 17120751 |
| Pathway ID |
Pathway Name |
|---|
| REACT:22258 |
Metabolism of lipids and lipoproteins |
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