AutismKB 2.0

Annotation Detail for MNS1


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Basic Information Top
Gene Symbol:MNS1 ( FLJ11222,FLJ26051 )
Gene Full Name: meiosis-specific nuclear structural 1
Band: 15q21.3
Quick LinksEntrez ID:55329; OMIM: 610766; Uniprot ID:MNS1_HUMAN; ENSEMBL ID: ENSG00000138587; HGNC ID: 29636
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MNS1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MNS1 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MNS1 mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of MNS1 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of MNS1 mRNAincreases expression 20106945
C030110 oxaliplatin oxaliplatin results in decreased expression of MNS1 mRNAdecreases expression 16510598
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MNS1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 15322242 11752688
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Estradiol 1.9117261762 16675129 12948864 18497071 17289903 17018787 14630087 19861407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7416924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.2218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15668235 15340226 16354765 12621046
MESH:D003110 Colonic Neoplasms oxaliplatin 3.2116024531 16004971 16510598
MESH:D015179 Colorectal Neoplasms oxaliplatin 2.9417594712 17401013 18509181 17695437 18448328 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7814986274 14550746 11461765 17562736 16227642 12392966 15968718 12540782 19085960 12705907 16081117 19370779 10915739 10663392 2444490 19164858 19923254 12153990 16109766 18713872 19416960 11529661 17522070 12594235 11421492 19420014 15619225 16485898 16781746 16393943 11834606 11743745 14725611 10774834 12958197 11739529 19739265 18071297 16177239 17906064 11287661
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Cyclosporine 9.7012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.7020067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.7916870215
MESH:D006930 Hyperalgesia oxaliplatin 8.7917418472
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.1316393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.8312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.838314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.8315618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 8.0615610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6816611625 16610002 19014921 11587558 12969438 12587719 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.742125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.348603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3614755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7217203775 11408345 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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