AutismKB 2.0

Annotation Detail for PPP3CC


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Basic Information Top
Gene Symbol:PPP3CC ( CALNA3,CNA3,PP2Bgamma )
Gene Full Name: protein phosphatase 3, catalytic subunit, gamma isozyme
Band: 8p21.3
Quick LinksEntrez ID:5533; OMIM: 114107; Uniprot ID:PP2BC_HUMAN; ENSEMBL ID: ENSG00000120910; HGNC ID: 9316
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
hsa04114Oocyte meiosis
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Apoptosis
Opioid Signalling
No data
Pathway IDPathway Name
P00053T cell activation
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
schizophrenia
Desease Name
HIV-1 control
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PPP3CC mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PPP3CC mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PPP3CC mRNAaffects expression 21346803
D003474 Curcumin Curcumin results in decreased expression of PPP3CC mRNAdecreases expression 17198877
D016572 Cyclosporine Cyclosporine results in increased expression of PPP3CC mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PPP3CC mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 11752688 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D050197 Atherosclerosis Curcumin 3.4918704882
MESH:D001327 Autoimmune Diseases Curcumin 4.9119761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D002545 Brain Ischemia Curcumin 4.7916770732
MESH:D001932 Brain Neoplasms Curcumin 4.2417596214
MESH:D001943 Breast Neoplasms Curcumin 2.1319250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1320435547
MESH:D002277 Carcinoma Curcumin 9.1418593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.1416835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0816705839
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0618414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8318462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 12621046 8697196 16354765 15668235
MESH:D003092 Colitis Curcumin 4.5918200517 16804969 16782535
MESH:D003103 Coloboma Curcumin 4.8818809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5419359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 5.3118497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.6218403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6217107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.2918204486
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004381 Duodenal Ulcer Curcumin 4.4317351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Curcumin 9.0019297423
MESH:D005234 Fatty Liver Cyclosporine 9.0019224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Curcumin 17.3618705752
MESH:D005355 Fibrosis Cyclosporine 17.3612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.3620067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1118462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005909 Glioblastoma Curcumin 3.6717596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8618829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4617701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 16354765 16959395 15340226 8697196
MESH:D006937 Hypercholesterolemia Curcumin 4.3818704882
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818670907 18850075
MESH:D007249 Inflammation Curcumin 5.5718403477 17151092 16956363
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5712878042 12200463
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3118200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.5210783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D007889 Leiomyoma Curcumin 4.9218555241
MESH:D007938 Leukemia Curcumin 3.3718462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5316106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.1416106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5517355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5512878042
MESH:D008107 Liver Diseases Curcumin 2.6716956363
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.707678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.342876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008175 Lung Neoplasms Curcumin 2.5216243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5211884234 19555203
MESH:D008223 Lymphoma Curcumin 3.8018462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1116173963
MESH:D008545 Melanoma Curcumin 2.4518462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.5317263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009101 Multiple Myeloma Curcumin 3.7319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3817962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7518495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.0512497104
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.1518462866
MESH:D009765 Obesity Curcumin 2.8019297423
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010024 Osteoporosis Curcumin 3.6518719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8919020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0217440100 19196508 19401701
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Curcumin 3.6311398177 18769126 18156803 18226269 10851300 12497104 15129424
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.8319168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3810666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012509 Sarcoma Curcumin 4.4218462866
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D018805 Sepsis Curcumin 4.3418389075
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013276 Stomach Ulcer Curcumin 3.8219188055 16631530
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9716049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.9718593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.7318462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
REACT:578 Apoptosis
KEGG:04210 Apoptosis
KEGG:04360 Axon guidance
KEGG:04662 B cell receptor signaling pathway
KEGG:04020 Calcium signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04380 Osteoclast differentiation
KEGG:04660 T cell receptor signaling pathway
KEGG:05152 Tuberculosis
KEGG:04370 VEGF signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33680
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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