AutismKB 2.0

Annotation Detail for STRBP


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Basic Information Top
Gene Symbol:STRBP ( DKFZp434N214,FLJ11307,FLJ14223,FLJ14984,FLJ21960,ILF3L,MGC21529,MGC3405,SPNR,p74 )
Gene Full Name: spermatid perinuclear RNA binding protein
Band: 9q33.1-q33.3
Quick LinksEntrez ID:55342; OMIM: 611138; Uniprot ID:STRBP_HUMAN; ENSEMBL ID: ENSG00000165209; HGNC ID: 16462
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STRBP mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of STRBP mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of STRBP mRNAdecreases expression 11793227
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STRBP mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of STRBP mRNAincreases expression 20458559
D002110 Caffeine Caffeine results in decreased expression of STRBP mRNAdecreases expression 11793227
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of STRBP mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of STRBP mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of STRBP mRNAincreases expression 18301758
17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of STRBP mRNAdecreases expression 20106945
D013853 Thioacetamide Thioacetamide results in decreased expression of STRBP mRNAdecreases expression 11793227
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1014514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3219825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.7417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 23.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 23.4719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 23.4712125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 23.4719483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.727296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.7211135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.721701930 6705139 20935162 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 11.7217997003
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.0616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 10.0618291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2719486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15668235 8697196 12621046 15340226
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 11906362 11298694 8970840 8156756 14531868 2524372 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.5118289764 16192314 8291058 6679447 6482804 7440962 18692083 9328219 9022650 1440618 11289319 18648102 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5114725611 15619225 16781746 19164858 11461765 19923254 17906064 17522070 11287661 12153990 18713872 11739529 12705907 19085960 19739265 16227642 10915739 16109766 18071297 11834606 10663392 10774834 19416960 12594235 16081117 11743745 19420014 11421492 14550746 16177239 16485898 12958197 17562736 11529661 15968718 19370779 2444490 16393943 12540782 14986274 12392966
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 12.5112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.603581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6012903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005218 Fat Necrosis Thioacetamide 5.9916456712
MESH:D005234 Fatty Liver arsenic trioxide 8.3015073043
MESH:D005234 Fatty Liver pirinixic acid 8.3019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.7418665440 17276928 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 17.116705139
MESH:D006505 Hepatitis Caffeine 17.1111394713
MESH:D006505 Hepatitis Thioacetamide 17.1116456712
MESH:D006529 Hepatomegaly Phenobarbital 15.6916109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6915340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16354765 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.8416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.846582329
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 19850784 16968895 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216823087 16330433 17712046 19642359 9834237 19225113 15622746 16331271 15213294 12018890 19075265 17107899 16891316 12712474 17649720 15336539 11161223 17869043 16112521 15748426 17217047 12679006 19035177 16966277 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.5612891558 11481614 17292413 17050028 12085344 18395095 12175628 12531686 18615449 18032466 15465738 18416461 16489207 16098781 18606216 14739098 15716488 18380797 18031379 18295389 18458672 15288473 16511523 17355460 12557150 15288472 16097051 15334695 16248980 15075984 10677585 11682029 15362042 12679928 17629604 15474484 17127702 15316131 16126171 11172339 15158331 15095483 15078482 18263696 16343077
MESH:D008107 Liver Diseases Acetaminophen 6.8016610002 16611625 12587719 12969438 19784758 19460945 11587558 19014921
MESH:D008107 Liver Diseases Phenobarbital 6.8019363144
MESH:D008107 Liver Diseases Thioacetamide 6.8016337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 10.1815633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms arsenic trioxide 11.1714682389
MESH:D008113 Liver Neoplasms Phenobarbital 11.1715975961 8742319 19812893 21047994 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 11.1720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.973712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.9720377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.971399818 17172636 6150874 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.9712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3411798837 19825857
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2215949261 19549372 14977855 11468182 19417148
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.616679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4316049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.436482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4519769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4816965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3018551238
MESH:D012640 Seizures Phenobarbital 6.3011442880 4039156 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D012893 Sleep Disorders Caffeine 5.5519395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.3617225163
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.743712494 6587162 1399818 7505956 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.7419014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.741399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6616049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.668074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6612973940 12845720 11780464 20435036
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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