AutismKB 2.0

Annotation Detail for CHDH


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Basic Information Top
Gene Symbol:CHDH ( - )
Gene Full Name: choline dehydrogenase
Band: 3p21.1
Quick LinksEntrez ID:55349; OMIM: NA; Uniprot ID:CHDH_HUMAN; ENSEMBL ID: ENSG00000016391; HGNC ID: 24288
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00260Glycine, serine and threonine metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of CHDH mRNAaffects expression 18343893
D000082 Acetaminophen Acetaminophen affects the expression of CHDH mRNAaffects expression 17562736
D001151 Arsenic CHDH protein affects the metabolism of Arsenicaffects metabolic processing 18682255
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHDH mRNAaffects cotreatment|increases expression 18164116
D002794 Choline CHDH gene SNP affects the susceptibility to Cholineaffects response to substance 17616785
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHDH mRNAaffects cotreatment|increases expression 18164116
D000431 Ethanol Ethanol results in increased expression of CHDH mRNAincreases expression 15353170
C006253 pirinixic acid pirinixic acid results in increased expression of CHDH mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of CHDH mRNAaffects expression 18343893
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.4417676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4411752688 15322242 14514962
MESH:D000138 Acidosis Ethanol 4.7811192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.256695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.0317162532 19061943 18056438 17620307 16434500 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.0316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.0316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5317306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.6415451040 15451039
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D000853 Anophthalmos Ethanol 5.0815513904
MESH:D001008 Anxiety Disorders Ethanol 4.1711141031
MESH:D020261 Arsenic Poisoning Arsenic 2.9118414634 16251483 12569548 16835338
MESH:D050197 Atherosclerosis Arsenic 3.3612928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Choline 2.3516818868
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002056 Burns Ethanol 4.9116374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6917687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.843084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.8417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8419539802 17162532 19171122 16681979 20935162 18788625 20524982 20432363 17978847 20214788 19701751 17761372 17428255 18494052 17173139 17055752 16288022 18210153 18506893 16328049 17138121 16878318 11831363 18691550 16779866 10672840 18785209 20727157 16807293 18056438 20512989 19052882 19519916 19107877 19822196 19418558 18978308 20101231 18665156 19383236 20084675 20514400 19335982 19208518 19394651 16502159 3581430 18393292 10737359 3084413 21159647 18971187 16698587 16569478 20007298 16935385 16540662 19919837 16830150
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.8418788625 15763234 15289165
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7418922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2718640142
MESH:D006332 Cardiomegaly Ethanol 7.1919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1918850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5815738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4916973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9921159647 7505956 17174075 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002971 Cleft Lip Ethanol 3.6815513904
MESH:D002972 Cleft Palate Ethanol 6.2015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.2015668235 12621046 15340226 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6810194807 11873399 15451039 15451040 19302082 15513904 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6815322242 20055451 10048152
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D002658 Developmental Disabilities Choline 4.8016818868
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4214986274 11743745 16227642 11529661 11461765 12392966 19739265 16485898 11287661 11739529 10915739 10663392 11834606 14725611 16081117 14550746 16177239 19370779 19085960 12705907 12958197 19416960 18071297 18713872 16109766 16393943 17906064 12153990 19923254 10774834 2444490 12540782 19164858 16781746 15619225 17562736 19420014 15968718 11421492 12594235 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.4219107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.4211566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms Ethanol 2.7916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 14.4020387270 21071580
MESH:D005234 Fatty Liver Ethanol 14.4018620774 19236843 16409862
MESH:D005234 Fatty Liver pirinixic acid 14.4019236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5816946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005534 Foot Diseases Arsenic 5.886392382
MESH:D005756 Gastritis Acetaminophen 12.2116983495
MESH:D005756 Gastritis Ethanol 12.2115046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 7.3111294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.3111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1419176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1412621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.3616870215
MESH:D006930 Hyperalgesia Ethanol 8.3618783367
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6517050553
MESH:D006973 Hypertension Arsenic 5.4516076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.8816093927
MESH:D007249 Inflammation Diethylnitrosamine 5.2218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Ethanol 10.8215513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.8216580747
MESH:D007642 Keratosis Arsenic 5.2816930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007859 Learning Disorders Ethanol 4.4715451040
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6817339181
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9617676605
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.1619638242 18407596 20032147 18665156 18522880
MESH:D008103 Liver Cirrhosis Ethanol 7.1615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3818295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5718166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008107 Liver Diseases Acetaminophen 6.8119014921 16611625 16610002 19784758 19460945 12969438 11587558 12587719
MESH:D008107 Liver Diseases Arsenic 6.8111134558
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8117034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9117207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 14.9916368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.9921295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.9919255062 19812893 19642983 20501860 21167192 19294768 21071580 18648771 20434301 19254457 20405173 18754104 19427195 15885732 2862719 18977376 20492335 20101389 10737359 18978307 19850985 15175105 19551842 2422723 20583210 20118626 19833225 20452335 16942905 19090486 21047994 18644402 19996281 12771043 19073162 12112319 9163691 19499222 19426721 19638242 20137499 21278145 19256749 19690152
MESH:D008113 Liver Neoplasms pirinixic acid 14.9915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9916984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.5818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.582563599 18775883 18308698 18544905 19126423 16267830 16842330 18079962 9362446 21159647 17854601 19004024 18093689 17174075 17942915 19009564 18282651 19539802 19519916 18253720 3124819 18164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5812151625
MESH:D008175 Lung Neoplasms Arsenic 3.5419168569 17976673 17306315
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5421163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008569 Memory Disorders Ethanol 4.4215451040 18411066
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Arsenic 9.5615371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.5612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Arsenic 3.5816620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.6017056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6516540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.6512384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4216093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.286392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 3.5816140617
MESH:D011507 Proteinuria Arsenic 4.2221343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures Ethanol 3.309754883
MESH:D012871 Skin Diseases Arsenic 2.7916353154 19834688 15952646 18709164 16759981 17453740 17938729 17050553 16702368 17548696 6392382
MESH:D012878 Skin Neoplasms Arsenic 6.0017029826 16251483 17976673 17050553 19538983 15504454
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6518456281
MESH:D013274 Stomach Neoplasms Ethanol 2.6518456281
MESH:D013276 Stomach Ulcer Ethanol 3.7317918041 9211565 16755016 17189318 11906479 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.459754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8818640142 11144890 19429237 19322015 17306315 17976673 15987713
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014652 Vascular Diseases Arsenic 5.0217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00122 - Choline Dietary supplement;Micronutrient;Nootropic Agents;Lipotropic Agents
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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