AutismKB 2.0

Annotation Detail for VNN3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:VNN3 ( HSA238982,MGC171203 )
Gene Full Name: vanin 3
Band: 6q23.2
Quick LinksEntrez ID:55350; OMIM: 606592; Uniprot ID:; ENSEMBL ID: ENSG00000093134; HGNC ID: 16431
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of VNN3 mRNAaffects expression 17562736
C019304 ciprofibrate ciprofibrate results in increased expression of VNN3 mRNAincreases expression 12771043
D004041 Dietary Fats Dietary Fats results in decreased expression of VNN3 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of VNN3 mRNAincreases expression 12771043
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of VNN3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VNN3 mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in decreased expression of VNN3 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of VNN3 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of VNN3 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in increased expression of VNN3 mRNAincreases expression 18301758
20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of VNN3 mRNA]increases expression|increases reaction 20059764
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VNN3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of VNN3 mRNAdecreases expression 18172886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.266195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2615322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.9610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 27.4318056438 19061943 17620307 19052882 16434500 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 27.4317620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 27.4316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 27.4316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 10.7915238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.7911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7016698587 18665156 17173139 10737359 18494052 17055752 20935162 18056438 17138121 20432363 19539802 16569478 20214788 18971187 20101231 19919837 19701751 20727157 20524982 18691550 20512989 16681979 18506893 18788625 19171122 19418558 19052882 20514400 19822196 10672840 16830150 16328049 17162532 16878318 16935385 19208518 18393292 16502159 20007298 17978847 19383236 16540662 16288022 3084413 19107877 16807293 17428255 18978308 17761372 18785209 16779866 20084675 18210153 3581430 19394651 19335982 11831363 19519916 21159647
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.701701930 20935162 6705139 17173139 20007298
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9921159647 7505956 17174075 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2517681005 17110522 11677210 15861022 17333356 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15668235 16354765 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4315619225 11739529 16081117 11461765 19923254 19739265 11834606 14550746 12958197 19416960 19370779 14725611 19085960 18713872 15968718 16781746 17562736 11743745 16227642 11529661 12705907 10663392 16177239 12594235 11421492 17906064 2444490 18071297 19420014 12392966 10915739 12540782 10774834 11287661 19164858 16109766 17522070 16485898 14986274 16393943 12153990
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.4319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Dietary Fats 20.5418296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 20.5420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5415345470
MESH:D005234 Fatty Liver pirinixic acid 20.5420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Dietary Fats 9.5018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Phenobarbital 15.9616109766
MESH:D006529 Hepatomegaly pirinixic acid 15.9616221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.9616120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3618606429 16354765 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Dietary Fats 8.8520412841
MESH:D007249 Inflammation Diethylnitrosamine 8.8518785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.6711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D008103 Liver Cirrhosis Dietary Fats 11.6418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.6418522880 18665156 18407596 19638242 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 11.6421047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Acetaminophen 6.7612587719 19784758 19460945 12969438 11587558 16611625 16610002 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7617034775
MESH:D008107 Liver Diseases Phenobarbital 6.7619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms ciprofibrate 15.0012771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 15.0015175105 10737359 18977376 20492335 19090486 12112319 21071580 15885732 20501860 19255062 18978307 19996281 2422723 16942905 18648771 20583210 2862719 18644402 19254457 20137499 20118626 21278145 19551842 19294768 20101389 9163691 19642983 12771043 19833225 21167192 19499222 19256749 21047994 19638242 19850985 19812893 20452335 19426721 18754104 20434301 19073162 19427195 19690152 20405173
MESH:D008113 Liver Neoplasms Phenobarbital 15.008742319 19812893 19073162 15975961 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 15.0020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.0016984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5218775883 19009564 18093689 19004024 18544905 19539802 18282651 17174075 18253720 2563599 18079962 9362446 19519916 16267830 18308698 16842330 21159647 3124819 17854601 18164116 17942915 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.526150874 17172636 2563599 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5212151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.3121163286 20512841 20970405 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3119555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity Dietary Fats 4.5817217161 20132043 16723640 18674790 18457598 19632207 21332399 11836018 20518802
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.712563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.712563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11896295 11118676 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures Phenobarbital 2.8216876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.701399818
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved