AutismKB 2.0

Annotation Detail for LAPTM4B


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Basic Information Top
Gene Symbol:LAPTM4B ( LAPTM4beta,LC27 )
Gene Full Name: lysosomal protein transmembrane 4 beta
Band: 8q22.1
Quick LinksEntrez ID:55353; OMIM: 613296; Uniprot ID:LAP4B_HUMAN; ENSEMBL ID: ENSG00000104341; HGNC ID: 13646
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LAPTM4B mRNAincreases expression 18648102
D016572 Cyclosporine Cyclosporine results in decreased expression of LAPTM4B mRNAdecreases expression 20106945
D002945 Cisplatin LAPTM4B protein affects the susceptibility to Cisplatinaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in decreased expression of LAPTM4B mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3815814532 12690470 17670903
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D000230 Adenocarcinoma Cisplatin 2.8311798837 17638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.6114601052
MESH:D001943 Breast Neoplasms Cisplatin 2.7619526202 18382427
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.347296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.3417982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1412023789 16685392
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.9117066447 18337622 6189445
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.457505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4512371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 15.1219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 15.1219486331
MESH:D002779 Cholestasis pirinixic acid 15.1219176532
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3518759878 11298694 12868966 8970840 8156756 2524372 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0418289764 18648102 18692083 11289319 7440962 9022650 6482804 9653073 1440618 9328219 6679447 16192314 8291058
MESH:D004362 Drug Toxicity Cisplatin 4.1512231392 12649298 19839026 15033597
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.913581430
MESH:D004938 Esophageal Neoplasms Cisplatin 4.9115464296 16785472 15173087 17638652 16481741
MESH:D005234 Fatty Liver Cyclosporine 9.0119224547
MESH:D005234 Fatty Liver pirinixic acid 9.0119236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005355 Fibrosis Cyclosporine 3.7012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9715464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.6719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7715464296
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006529 Hepatomegaly pirinixic acid 3.5519176532 16221962 18467677 19772884
MESH:D006689 Hodgkin Disease Cisplatin 3.9616200630 16170182
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.8615464296
MESH:D007674 Kidney Diseases Cisplatin 6.8619839026 12649298 15190930 18289764 12231392
MESH:D007674 Kidney Diseases Cyclosporine 6.868314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.436582329
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4312371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.5211231351
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.751399818 3712494 6587162 598648
MESH:D008175 Lung Neoplasms Cisplatin 2.3411798837 17225452 6189445
MESH:D008545 Melanoma Cisplatin 2.5118176117 16248763 18332650 17023156 11135225 15577323 12883367 16432458 12374674 18505091 12393984 17761969 16809738
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.4115990972
MESH:D008654 Mesothelioma Cisplatin 3.3717638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009369 Neoplasms Cisplatin 5.6716773208
MESH:D009369 Neoplasms pirinixic acid 5.6717405874
MESH:D009395 Nephritis, Interstitial Cisplatin 5.2115464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009447 Neuroblastoma Cisplatin 3.628761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.338761367
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.814026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9719769630 17225452 15464296 6897625
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.1019003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.8115464296
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D010997 Pleural Neoplasms Cisplatin 6.0717638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D051437 Renal Insufficiency Cisplatin 4.9715464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.9314601052
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 6.0715464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3315958060 18396642 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 5.0915464296 17225452
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.196582329 3712494 1399818 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.678074119
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.6717225452 15464296 12973940
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.6016803524
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014625 Vaginal Neoplasms Cisplatin 5.1715577323
MESH:D014839 Vomiting Cisplatin 5.4411897121
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
Pathway ID Pathway Name
KEGG:04142 Lysosome
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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