AutismKB 2.0

Annotation Detail for PI4K2A


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Basic Information Top
Gene Symbol:PI4K2A ( DKFZp761G1923,PI4KII,PIK42A,RP11-548K23.6 )
Gene Full Name: phosphatidylinositol 4-kinase type 2 alpha
Band: 10q24.2
Quick LinksEntrez ID:55361; OMIM: 609763; Uniprot ID:P4K2A_HUMAN; ENSEMBL ID: ENSG00000155252,ENSG00000249967; HGNC ID: 30031
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63523-phosphoinositide biosynthesis
PWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
Pathway IDPathway Name
200064Canonical Wnt signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PI4K2A mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PI4K2A mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PI4K2A mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PI4K2A mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PI4K2A mRNAincreases expression 18687144
D005419 Flavonoids Flavonoids results in increased expression of PI4K2A mRNAincreases expression 18035473
D014501 Uranium Uranium affects the expression of PI4K2A mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of PI4K2A mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.683581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.329022650 19486331
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108970840 2524372 8156756 11906362 11298694 14531868 18759878 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5318289764 6679447 18692083 7440962 8291058 9022650 9653073 11289319 18648102 6482804 9328219 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5317522070 11287661 12153990 12958197 12594235 19739265 10774834 14725611 16393943 14986274 19164858 16177239 16485898 18071297 19420014 19416960 12540782 11739529 2444490 17906064 14550746 11743745 11421492 11834606 19923254 16109766 17562736 16781746 12392966 16227642 15619225 18713872 11529661 16081117 19370779 12705907 10663392 11461765 10915739 19085960 15968718
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007249 Inflammation Flavonoids 2.7517296493
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 16611625 19784758 11587558 19460945 12969438 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.362876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.363712494 598648 1399818 6587162
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2616966607 18303189 16166281
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1017322281 17365031 15814490 17975199
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066582329 1399818 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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