AutismKB 2.0

Annotation Detail for TMEM176A


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Basic Information Top
Gene Symbol:TMEM176A ( GS188,HCA112 )
Gene Full Name: transmembrane protein 176A
Band: 7q36.1
Quick LinksEntrez ID:55365; OMIM: 610334; Uniprot ID:T176A_HUMAN; ENSEMBL ID: ENSG00000002933; HGNC ID: 24930
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM176A mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TMEM176A proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TMEM176A mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMEM176A mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM176A mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of TMEM176A mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TMEM176A mRNAdecreases expression 17108234
D017239 Paclitaxel Paclitaxel analog results in decreased expression of TMEM176A mRNAdecreases expression 15585946
D017239 Paclitaxel Paclitaxel results in decreased expression of TMEM176A mRNAdecreases expression 15585946
C041786 palm oil palm oil results in decreased expression of TMEM176A mRNAdecreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMEM176A mRNAincreases expression 15328365
D014810 Vitamin E Vitamin E results in increased expression of TMEM176A mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0414514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.7215867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Paclitaxel 1.9718323546 11325840 16115903 15136595 16273361 16244791 18223236 18234424
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.5316011737 15721981 16124888 16192424 16097048 15700767 18705752 15673190 10355542 16227642 3786805 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.5316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.763084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7612619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7618788625
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.7616313753
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1216919318 15861022 16105132 17333356 17681005 11677210 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15668235 8697196 15340226 12621046
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3411461765 10663392 14725611 11834606 11287661 19370779 12153990 15968718 18071297 12392966 16781746 16393943 19416960 17522070 17906064 16485898 10915739 19923254 12705907 19164858 18713872 12594235 16177239 11739529 19739265 17562736 11421492 2444490 15619225 16081117 19085960 16227642 12540782 14550746 10774834 12958197 16109766 14986274 19420014 11529661 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3416227642 15027814 16177239 10092053 9327722 7179309 19085960 21278145 6623471 3732212 15968718 19336974 11566570 3786805 7440962 6884620 4309450 7120509 15998439 10915739 17522070 2869522
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7616530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.7616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.9615959796 16045604 16239168 19224547 17595544 61145 12631006 12795759
MESH:D005234 Fatty Liver Cyclosporine 19.9619224547
MESH:D005234 Fatty Liver Dietary Fats 19.9618296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 22.6918705752
MESH:D005355 Fibrosis Cyclosporine 22.6912168785 12639820
MESH:D005355 Fibrosis Dietary Fats 22.6918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.6920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5016080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Dietary Fats 5.1420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1412200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.4316624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1911836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.4518776723 8314463 10903974
MESH:D007674 Kidney Diseases Vitamin E 10.4512488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D008080 Liposarcoma Paclitaxel 4.9717353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.8716943688 21278145 17174718 17334410 11903743 11408273 17157831 16221502 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5415057751 17631135 18395914 17525996 12389079 18205269 12445418 12958196 18006644 18339082 17976157 15996030 17565644 15876570 12649538 12667390 17557913 17721639 12546737 13678700 17823541 18187930 12666154 15673190 15370692 18429990 14512876 18210741 17481882 15893842 18705752 10355542 14716496 12586293 18420326 16192424 15052691 16027843 16116963 12632514 18277467 12632512 15925388 15650968 14716833 17766677 11481614 15123356 18472332 12741479 12609069 16248980 16136751 17640975 18481824 18156304 17944888 15362042 20821823 17805973 14724832 15730626 15818738 18279442 12898905 18418968 16011737 15338365 17761835 12445421 18166357 16638106 17714472 18054572 18472094 17698563 17900296 14748882 18412020 18317297 15959796 18251166 17922224 18376398 16033810 17869086 14620537 18263696 16097048 16015684 15931870 18395095 17708605
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5416169303
MESH:D008107 Liver Diseases Acetaminophen 4.0019784758 12969438 19014921 16611625 19460945 12587719 16610002 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0017285989 16246199 16964402 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8516899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.099163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0921137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.308603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3012151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9518816296 18520028 20869020 17053015 20064080 20464547 18569708 6695378 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.9511062179
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2114749477
MESH:D008545 Melanoma Paclitaxel 2.6012025231 12040289 16342250
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.7814749477
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3015867366
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity Dietary Fats 2.3117217161 21332399 11836018 18674790 16723640 20132043 19632207 18457598 20518802
MESH:D010014 Osteolysis Paclitaxel 5.1715867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0311161223
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6017292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.6017136230 16356831 16729912 17172428
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.612093021 20155912
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6118506536 18396642
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D024801 Tauopathies Paclitaxel 5.0116930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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