AutismKB 2.0

Annotation Detail for LGR4


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Basic Information Top
Gene Symbol:LGR4 ( GPR48 )
Gene Full Name: leucine-rich repeat-containing G protein-coupled receptor 4
Band: 11p14.1
Quick LinksEntrez ID:55366; OMIM: 606666; Uniprot ID:LGR4_HUMAN; ENSEMBL ID: ENSG00000205213; HGNC ID: 13299
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Schizophrenia, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LGR4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LGR4 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LGR4 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of LGR4 mRNAdecreases expression 16239168
D016572 Cyclosporine Cyclosporine results in decreased expression of LGR4 mRNAdecreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of LGR4 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LGR4 mRNAdecreases expression 12655037
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of LGR4 mRNAaffects cotreatment|increases expression 17183730
D008942 Mitoxantrone LGR4 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of LGR4 mRNAdecreases expression 17616710
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of LGR4 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618558336 18775368 18316065 17688650 18985861 18177632 17507914 18396377 15238991 16609825 20603192 19232924 19460635 18940202 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.1417594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D001943 Breast Neoplasms Calcitriol 2.5911237771
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516097048 15721981 18705752 16227642 16192424 15673190 10355542 15700767 16011737 16050911 3786805 16124888
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9018788625
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6611237771
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8712371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1216919318 15861022 17681005 11677210 16105132 17110522 17333356
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4316393943 19416960 14550746 14725611 17562736 12958197 18713872 16109766 19370779 19739265 19420014 11461765 16485898 16081117 11739529 17522070 12153990 16227642 12392966 11287661 10774834 19923254 10663392 2444490 18071297 14986274 12540782 11834606 15619225 10915739 19164858 16177239 11529661 15968718 12594235 19085960 11743745 11421492 12705907 16781746 17906064
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.432869522 16177239 15968718 19085960 9327722 7440962 21278145 10092053 16227642 3786805 17522070 7179309 6884620 7120509 4309450 15998439 10915739 6623471 19336974 15027814 3732212 11566570
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.431733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.6415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6412538720
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.133922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7420426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7415150132 16510608 15623463 15264214 16704527 15547733 16805852 15878914 15547721
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.9712631006 16045604 15959796 17595544 61145 16239168 12795759 19224547
MESH:D005234 Fatty Liver Cyclosporine 19.9719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.9715345470
MESH:D005234 Fatty Liver Valproic Acid 19.9719224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.298888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2618705752
MESH:D005355 Fibrosis Cyclosporine 9.2612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006331 Heart Diseases Mitoxantrone 4.2416019553
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619110552 19900420
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.0512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.0518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8418172266
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8811903743 11408273 17334410 16943688 16221502 17157831 16239168 21278145 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515123356 16136751 11481614 15730626 18156304 17708605 18339082 17557913 15052691 14716496 18187930 15925388 18166357 15818738 12667390 17714472 15362042 14620537 18481824 12389079 17976157 18472094 16011737 17698563 17900296 18277467 12632512 18472332 16192424 17761835 16116963 17922224 17631135 15338365 15057751 12546737 18705752 16027843 16097048 16248980 17944888 16015684 18317297 12649538 17525996 18412020 15876570 14748882 18395095 16638106 12958196 15370692 14716833 18251166 18263696 12666154 15893842 12445418 12609069 12898905 15650968 18395914 15959796 15673190 17640975 17805973 12445421 12632514 14724832 17481882 17766677 14512876 16033810 18210741 18418968 17823541 20821823 18006644 17565644 17869086 18420326 15931870 13678700 18054572 12741479 18429990 18279442 18376398 17721639 12586293 15996030 10355542 18205269
MESH:D008107 Liver Diseases Acetaminophen 4.0012587719 19784758 16611625 19014921 11587558 12969438 16610002 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0015720792 17285989 16964402 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.2719294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6912014681 15583823
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2918765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009369 Neoplasms Mitoxantrone 3.4816640825
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5215754350 16289102 12479363 18247401 16644109
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.7612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia marker/mechanism
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8314763951 11738929 11044598 15475178 3137016 16876388 1511512 17978042
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3317575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6815869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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