AutismKB 2.0

Annotation Detail for MEG3


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Basic Information Top
Gene Symbol:MEG3 ( FLJ31163,FLJ42589,FLJ44703,FP504,GTL2,NCRNA00023,PRO0518,PRO2160,prebp1 )
Gene Full Name: maternally expressed 3 (non-protein coding)
Band: 14q32.2
Quick LinksEntrez ID:55384; OMIM: 605636; Uniprot ID:; ENSEMBL ID: ; HGNC ID: 14575
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MEG3 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MEG3 mRNAincreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MEG3 mRNAaffects expression 17484886
C014347 decitabine decitabine inhibits the reaction [tobacco tar results in decreased expression of MEG3 mRNA]decreases expression|decreases reaction 19559774
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEG3 mRNAaffects cotreatment|increases expression 17942748
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of MEG3 mRNAdecreases expression 17317680
D015073 2-Acetylaminofluorene TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in decreased expression of MEG3 mRNA]affects reaction|decreases expression 17317680
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MEG3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of MEG3 mRNAincreases expression 19270015
19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of MEG3 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MEG3 mRNA]decreases expression|increases reaction 20059764
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MEG3 mRNA]affects reaction|decreases expression 16891777
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MEG3 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MEG3 mRNAdecreases expression 16891777
C024746 tobacco tar decitabine inhibits the reaction [tobacco tar results in decreased expression of MEG3 mRNA]decreases expression|decreases reaction 19559774
C024746 tobacco tar tobacco tar results in decreased expression of MEG3 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 3.8310737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.276705139
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.7417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.7416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.7416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms decitabine 2.0819208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916050911 15700767 16227642 16124888 10355542 16011737 18705752 15721981 3786805 16192424 15673190 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.803084413 6705139 10737359 3581430 17761372
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.803084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8018788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.8017173139 1701930 6705139 20935162 20007298
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6319215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4620889678
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.4619559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1711677210 17681005 17333356 17110522 16105132 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 8.1719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 8697196 15668235 12621046 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3911421492 19370779 12958197 12153990 16177239 18713872 16109766 11743745 19085960 16393943 17522070 11739529 12392966 17562736 15968718 12594235 11461765 17906064 19739265 19164858 10774834 10663392 14725611 2444490 16081117 19923254 12705907 16485898 16227642 19420014 14986274 14550746 10915739 12540782 19416960 11529661 11287661 15619225 16781746 11834606 18071297
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3910092053 10915739 15027814 2869522 3732212 16227642 11566570 7440962 7120509 16177239 3786805 15968718 15998439 19085960 4309450 21278145 19336974 17522070 6623471 9327722 6884620 7179309
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3819294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.143922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.0712795759 17595544 12631006 16045604 15959796 16239168 61145 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.0715345470
MESH:D005234 Fatty Liver pirinixic acid 14.0719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6019215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.586705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.586705139
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 15.6916109766
MESH:D006529 Hepatomegaly pirinixic acid 15.6916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.6915340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male decitabine 7.0917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007938 Leukemia decitabine 3.1519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1719117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4019387464 19010910 18704418 18460780 18206229 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.9317157831 16239168 16943688 11903743 11408273 16221502 21278145 17174718 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9321047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4815818738 16097048 16136751 17944888 17714472 11481614 18277467 18420326 12546737 18263696 15730626 15057751 12649538 18166357 17823541 18339082 15673190 18279442 18376398 16027843 12958196 15650968 17557913 14724832 17481882 20821823 12586293 12445418 12632514 14716833 12898905 12667390 17869086 15123356 12666154 15052691 14748882 16033810 15338365 15362042 18412020 12445421 15996030 16192424 18251166 17766677 17761835 17698563 17805973 17565644 12741479 18317297 14716496 12389079 18472332 15876570 18210741 15925388 18472094 18395095 16248980 15370692 17708605 17525996 18395914 14620537 16015684 16116963 15931870 17631135 16638106 17721639 17922224 12632512 18705752 18187930 14512876 12609069 15959796 17640975 15893842 17976157 18054572 18006644 18418968 18481824 18205269 18429990 10355542 16011737 18156304 17900296 13678700
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008107 Liver Diseases Acetaminophen 6.7119460945 12587719 19014921 16610002 12969438 16611625 11587558 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7116964402 15720792 15830285 16246199 17285989
MESH:D008107 Liver Diseases Phenobarbital 6.7119363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 14.8816273603 14678523 18001218 11376686 10672840 10737359
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.8819294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.8819812893 19073162 8742319 15975961 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 14.8820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8816984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 15.026150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.0212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.0218308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.0212151625
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.6311376686
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6319555203 11884234
MESH:D008223 Lymphoma decitabine 3.5419470736
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009101 Multiple Myeloma decitabine 3.4618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4719010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009369 Neoplasms decitabine 5.2819116145 19470736 17925555
MESH:D009369 Neoplasms pirinixic acid 5.2817405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms decitabine 2.6919259094 19331143
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.5719294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.9417616702
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
MESH:D012640 Seizures Phenobarbital 2.8016876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms decitabine 7.7517967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.751399818
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.7315289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.7319087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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