AutismKB 2.0

Annotation Detail for PRELP


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Basic Information Top
Gene Symbol:PRELP ( MGC45323,MST161,MSTP161,SLRR2A )
Gene Full Name: proline/arginine-rich end leucine-rich repeat protein
Band: 1q32.1
Quick LinksEntrez ID:5549; OMIM: 601914; Uniprot ID:PRELP_HUMAN; ENSEMBL ID: ENSG00000188783; HGNC ID: 9357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRELP mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PRELP mRNAdecreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRELP mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of PRELP mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRELP mRNAincreases expression 15834898
D005419 Flavonoids Flavonoids results in decreased expression of PRELP mRNAdecreases expression 18035473
C010176 halofuginone halofuginone results in increased expression of PRELP mRNAincreases expression 17180598
C041786 palm oil palm oil results in decreased expression of PRELP mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PRELP mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PRELP mRNAdecreases expression 19482888
C017947 sodium arsenite sodium arsenite results in decreased expression of PRELP mRNAdecreases expression 20308225
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRELP mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRELP mRNAincreases expression 16960034
D014810 Vitamin E Vitamin E results in increased expression of PRELP mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.816195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8115322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3711798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.6016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0816712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.3815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.3316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.4015721981 10355542 16011737 18705752 16227642 3786805 15673190 16192424 15700767 16050911 16124888 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.4016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.7314691202 11135700 16217749 15073043 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7318788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.731701930 6705139 20007298 17173139 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7316507464 17306315 15276417
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0619524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9511677210 16105132 17681005 17110522 17333356 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 12621046 15340226 15668235 8697196
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8320055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8319769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.824309450 19336974 10092053 7179309 2869522 15968718 17522070 3732212 21278145 19085960 15027814 16177239 16227642 11566570 10915739 15998439 9327722 3786805 6884620 7120509 7440962 6623471
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3312903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver arsenic trioxide 19.7215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7261145 16239168 12795759 16045604 12631006 15959796 19224547 17595544
MESH:D005234 Fatty Liver Dietary Fats 19.7219551842 18296743 19004024 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7215345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.6018705752
MESH:D005355 Fibrosis Dietary Fats 15.6018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7516080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 8.9116109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16354765 8697196 18606429 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D006965 Hyperplasia halofuginone 5.3811874485
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8817937319
MESH:D007248 Infertility, Male sodium arsenite 6.8815346721 12646999
MESH:D007249 Inflammation Dietary Fats 8.6320412841
MESH:D007249 Inflammation Flavonoids 8.6317296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6312878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.3916624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1718457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases sodium arsenite 6.3920008137
MESH:D007674 Kidney Diseases Vitamin E 6.3912488133
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516968895 19850784 16467208 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2816823087 11161223 17649720 15336539 9834237 17217047 19035177 16330433 17107899 15622746 15213294 19075265 19642359 16331271 16891316 19225113 11468182 12679006 17712046 12018890 16112521 15748426 12712474 16966277 17869043
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 16.2917174718 17157831 17334410 16943688 21278145 11408273 16239168 11903743 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 16.2918296743
MESH:D008103 Liver Cirrhosis halofuginone 16.2917180598
MESH:D008103 Liver Cirrhosis Phenobarbital 16.2921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.1015925388 18187930 18395914 18481824 18472332 17944888 17525996 17481882 18277467 18705752 17698563 20821823 18210741 18263696 18279442 15123356 16248980 18317297 15673190 18472094 15730626 15052691 18418968 11481614 12389079 17766677 17761835 16136751 15818738 12586293 15876570 15057751 12445421 17869086 12632514 16011737 12666154 16097048 16027843 18395095 17823541 16116963 18429990 16192424 12546737 17922224 10355542 14724832 13678700 17565644 14716496 17900296 16015684 15959796 17708605 12649538 15338365 16033810 17714472 18006644 18376398 12445418 14512876 12958196 18412020 17976157 18251166 18420326 12667390 12741479 17721639 18339082 14748882 18054572 18156304 15996030 15370692 17631135 17805973 15893842 17557913 12632512 12898905 15931870 18205269 18166357 14620537 15650968 17640975 14716833 16638106 12609069 15362042
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 5.1018458672 14739098 12175628 16489207 11172339
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1016169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1816964402 16246199 15720792 17285989 15830285
MESH:D008107 Liver Diseases Phenobarbital 4.1819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 14.6614682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.6619294768
MESH:D008113 Liver Neoplasms Phenobarbital 14.6615975961 8742319 19482888 19812893 21047994 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 14.6616712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.6720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.672563599 17172636 1399818 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.6712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008171 Lung Diseases sodium arsenite 7.6819095001
MESH:D008171 Lung Diseases Vitamin E 7.6816863852
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9411798837 19825857
MESH:D008175 Lung Neoplasms sodium arsenite 4.9415276417 16712894 19931552 17077188 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 4.9411062179
MESH:D008545 Melanoma sodium arsenite 2.0419082730 16487513
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1819549372 14977855 19417148 15949261 11468182
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009369 Neoplasms sodium arsenite 2.5411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5710525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.5712854658
MESH:D009765 Obesity Dietary Fats 2.3119632207 18457598 20518802 20132043 18674790 21332399 16723640 11836018 17217161
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0117306315 15276417
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4215580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.722563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5719131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures Phenobarbital 2.763137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012871 Skin Diseases halofuginone 5.4111874485
MESH:D012871 Skin Diseases Vitamin E 5.4118709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.7519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5019014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.501399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2912973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2917306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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