AutismKB 2.0

Annotation Detail for H2AFY2


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Basic Information Top
Gene Symbol:H2AFY2 ( macroH2A2 )
Gene Full Name: H2A histone family, member Y2
Band: 10q22.1
Quick LinksEntrez ID:55506; OMIM: NA; Uniprot ID:H2AW_HUMAN; ENSEMBL ID: ENSG00000099284; HGNC ID: 14453
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05322Systemic lupus erythematosus
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of H2AFY2 mRNAaffects expression 17562736
D012643 Selenium Selenium results in increased expression of H2AFY2 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite affects the expression of H2AFY2 mRNAaffects expression 19590694
D014810 Vitamin E Vitamin E results in increased expression of H2AFY2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6316712894 17306315
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.043084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0417306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2519524636 20056578
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1016177239 19923254 12705907 10663392 17906064 19739265 12958197 10774834 14725611 19420014 16781746 17562736 11834606 18713872 16227642 11743745 17522070 12392966 11421492 12594235 16109766 16485898 19416960 10915739 19085960 2444490 18071297 16393943 11461765 14550746 14986274 12153990 16081117 19370779 15968718 11529661 11287661 15619225 12540782 19164858 11739529
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:C538011 Eales disease Vitamin E 5.439068938
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1716080930
MESH:D006333 Heart Failure Selenium 3.2917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8116490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D019584 Hot Flashes Vitamin E 4.6914716179
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007248 Infertility, Male sodium arsenite 3.2415346721 12646999
MESH:D007251 Influenza, Human Selenium 13.5016624496
MESH:D007251 Influenza, Human Vitamin E 13.5016624496
MESH:D007674 Kidney Diseases Acetaminophen 11.2812587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 11.2820008137
MESH:D007674 Kidney Diseases Vitamin E 11.2812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 16610002 19460945 11587558 19784758 16611625 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms sodium arsenite 2.4815276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 8.2919095001
MESH:D008171 Lung Diseases Vitamin E 8.2916863852
MESH:D008175 Lung Neoplasms sodium arsenite 2.6317077188 17306315 19931552 16712894 15276417
MESH:D008175 Lung Neoplasms Vitamin E 2.6311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9915318939
MESH:D008545 Melanoma sodium arsenite 2.0719082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D009369 Neoplasms sodium arsenite 2.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5317306315 15276417
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2316039940
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2315084515
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D020521 Stroke Vitamin E 3.8416517955
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6311723127 17306315 16452187 16712894
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
REACT:27235 Meiotic Recombination (mouse)
KEGG:05322 Systemic lupus erythematosus
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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