AutismKB 2.0

Annotation Detail for SMPD3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SMPD3 ( FLJ22593,MGC138443,NSMASE2 )
Gene Full Name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Band: 16q22.1
Quick LinksEntrez ID:55512; OMIM: 605777; Uniprot ID:NSMA2_HUMAN; ENSEMBL ID: ENSG00000103056; HGNC ID: 14240
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY3DJ-11281sphingomyelin metabolism
Pathway IDPathway Name
hsa00600Sphingolipid metabolism
hsa01100Metabolic pathways
No data
Pathway IDPathway Name
200100Ceramide signaling pathway
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SMPD3 mRNAincreases expression 19933214
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SMPD3 mRNAincreases expression 20005886
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SMPD3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SMPD3 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of SMPD3 mRNAincreases expression 20458559
C080985 batimastat batimastat inhibits the reaction [Tyramine results in increased activity of SMPD3 protein]decreases reaction|increases activity 17561096
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene inhibits the reaction [Tyramine results in increased activity of SMPD3 protein]decreases reaction|increases activity 17561096
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of SMPD3 promoter] which affects the expression of SMPD3 mRNAaffects cotreatment|affects expression|affects methylation 18836996
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of SMPD3 mRNAincreases expression 20387270
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SMPD3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SMPD3 mRNAincreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of SMPD3 mRNAincreases expression 18035473
C468773 GW 4869 GW 4869 results in increased activity of SMPD3 proteinincreases activity 12566438
D015636 Magnesium Chloride [Magnesium Chloride co-treated with Phosphatidylserines] promotes the reaction [SMPD3 protein results in increased degradation of Sphingomyelins]affects cotreatment|increases degradation|increases reaction 12566438
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SMPD3 mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in increased expression of SMPD3 mRNAincreases expression 19482888
D010718 Phosphatidylserines [Magnesium Chloride co-treated with Phosphatidylserines] promotes the reaction [SMPD3 protein results in increased degradation of Sphingomyelins]affects cotreatment|increases degradation|increases reaction 12566438
D010718 Phosphatidylserines Phosphatidylserines results in increased activity of SMPD3 proteinincreases activity 12566438
C006253 pirinixic acid pirinixic acid results in decreased expression of SMPD3 mRNAdecreases expression 17426115
D017382 Reactive Oxygen Species [Tyramine results in increased activity of MAOA protein] promotes the reaction [[Reactive Oxygen Species results in increased activity of MMP2 protein] which results in increased activity of SMPD3 protein]increases activity|increases reaction 17561096
C063456 Ro 41-1049 Ro 41-1049 inhibits the reaction [Tyramine results in increased activity of SMPD3 protein]decreases reaction|increases activity 17561096
D013109 Sphingomyelins [Magnesium Chloride co-treated with Phosphatidylserines] promotes the reaction [SMPD3 protein results in increased degradation of Sphingomyelins]affects cotreatment|increases degradation|increases reaction 12566438
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SMPD3 mRNAdecreases expression 20005886
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SMPD3 mRNAincreases expression 19933214
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of SMPD3 promoter] which affects the expression of SMPD3 mRNAaffects cotreatment|affects expression|affects methylation 18836996
D014439 Tyramine batimastat inhibits the reaction [Tyramine results in increased activity of SMPD3 protein]decreases reaction|increases activity 17561096
D014439 Tyramine Butylated Hydroxytoluene inhibits the reaction [Tyramine results in increased activity of SMPD3 protein]decreases reaction|increases activity 17561096
D014439 Tyramine Ro 41-1049 inhibits the reaction [Tyramine results in increased activity of SMPD3 protein]decreases reaction|increases activity 17561096
D014439 Tyramine [Tyramine results in increased activity of MAOA protein] promotes the reaction [[Reactive Oxygen Species results in increased activity of MMP2 protein] which results in increased activity of SMPD3 protein]increases activity|increases reaction 17561096
D014439 Tyramine [Tyramine results in increased activity of MMP2 protein] which results in increased activity of SMPD3 proteinincreases activity 17561096
D014439 Tyramine Tyramine results in increased activity of SMPD3 proteinincreases activity 17561096
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.796195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7914514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.1619825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.766695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.6117162532 16434500 17620307 19052882 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.4716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.4719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001930 Brain Injuries Magnesium Chloride 6.2010506531
MESH:D001943 Breast Neoplasms decitabine 1.8819208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.6014691202 11135700 15073043 16217749 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.6017138121 20101231 16288022 18788625 17173139 16540662 19335982 20512989 19052882 20935162 18210153 10672840 21159647 17162532 16502159 16830150 19539802 16569478 16328049 18494052 19822196 16698587 20007298 17055752 19171122 16935385 18393292 18691550 3084413 18056438 3581430 19519916 19208518 16681979 19701751 20514400 18506893 19394651 16779866 19919837 17978847 20084675 17761372 19418558 16878318 19383236 10737359 18785209 18978308 18971187 20727157 18665156 20214788 16807293 20432363 20524982 11831363 19107877 17428255
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.6017173139 20935162 20007298 1701930 6705139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9812490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.752727394 17174075 7505956 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3711677210 16105132 15861022 17681005 17333356 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 7.3719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0412621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3117616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5520501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5518981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8310525206
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 3.8315736158
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8320055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9515213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.5717562736 14550746 19164858 18071297 19370779 11461765 2444490 12153990 11529661 16781746 12392966 14725611 12594235 18713872 16227642 16177239 14986274 12540782 10663392 19416960 16081117 17906064 11834606 11421492 16109766 19085960 10774834 15968718 12958197 17522070 16485898 19739265 19923254 11287661 19420014 12705907 15619225 11743745 16393943 10915739 11739529
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.5719107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.5219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.5219294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.899294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7211558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.5915623463 15878914 16805852 15264214 15150132 15547733 16704527 16510608 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver arsenic trioxide 17.6115073043
MESH:D005234 Fatty Liver Diethylnitrosamine 17.6121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.6115345470
MESH:D005234 Fatty Liver pirinixic acid 17.6119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8020067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1116904648
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005909 Glioblastoma trichostatin A 3.7318801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3919215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly Phenobarbital 13.5116109766
MESH:D006529 Hepatomegaly pirinixic acid 13.5118467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5116120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916354765 8697196 16959395 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3717604070
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male decitabine 6.3917581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3917937319
MESH:D007249 Inflammation Diethylnitrosamine 7.8518785209
MESH:D007249 Inflammation Flavonoids 7.8517296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8512200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.8219381132
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1112587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 2.8516705839
MESH:D007938 Leukemia arsenic trioxide 6.2015070760
MESH:D007938 Leukemia decitabine 6.2019235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.1219077051
MESH:D007951 Leukemia, Myeloid decitabine 9.1217236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0916968895 17050201 19850784 16467208 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0919387464 17679729 19010910 18704418 18206229 18460780
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.0918206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1215748426 17649720 17217047 12679006 16330433 15622746 11468182 17869043 9834237 16823087 19035177 16966277 12018890 19642359 15336539 19075265 16331271 17712046 16112521 15213294 11161223 16891316 12712474 17107899 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2016882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3718522880 18407596 20032147 19638242 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 6.3721047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.0915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.0912878042
MESH:D008107 Liver Diseases Acetaminophen 6.2511587558 16611625 19784758 12969438 16610002 19014921 19460945 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2517034775
MESH:D008107 Liver Diseases Phenobarbital 6.2519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1016871587 17185352
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 21.0416835634 18644402
MESH:D008113 Liver Neoplasms arsenic trioxide 21.0414682389
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 21.0418177683
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.0420137499 18978307 16942905 19850985 21047994 20583210 21278145 19256749 18754104 19255062 12112319 19996281 12771043 19294768 19812893 20501860 20101389 19551842 15175105 18977376 19690152 20492335 19426721 20405173 19638242 20118626 19833225 10737359 20452335 15885732 18644402 2862719 18648771 21167192 19427195 21071580 19499222 20434301 19073162 19642983 2422723 19254457 19090486 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 21.0421047994 19482888 19812893 8742319 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 21.0415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.0416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.3420377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.3418079962 19519916 19126423 19004024 18775883 18282651 18544905 16267830 3124819 2563599 17942915 18093689 21159647 19539802 9362446 16842330 18253720 18164116 17854601 18308698 19009564 17174075
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.346150874 17172636 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.7419825857 11798837
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 4.7411696405 18597497 19359593 11246140 15390079 19925653 16337739
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7420970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7411884234 19555203
MESH:D008223 Lymphoma decitabine 3.3119470736
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 3.651500032
MESH:D008545 Melanoma decitabine 5.2516505122 17785578
MESH:D008545 Melanoma Reactive Oxygen Species 5.2517992120
MESH:D008545 Melanoma trichostatin A 5.2516505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008881 Migraine Disorders Tyramine 5.2410792367
MESH:D009101 Multiple Myeloma arsenic trioxide 11.6114977855 15949261 11468182 19417148 19549372
MESH:D009101 Multiple Myeloma decitabine 11.6118172295
MESH:D009101 Multiple Myeloma trichostatin A 11.6118172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2216105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.2219157545 16882708 18608210 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8116624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.513581430 9029167
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 8.008820588
MESH:D009369 Neoplasms decitabine 8.0019116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 8.0017405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2912819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.7616624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 7.7619259094 19331143
MESH:D010051 Ovarian Neoplasms trichostatin A 7.7619331143
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.8115580305
MESH:D010190 Pancreatic Neoplasms decitabine 19.8119294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.8116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 19.8116965848
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 19.8115580305
MESH:D010190 Pancreatic Neoplasms trichostatin A 19.8119294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D011014 Pneumonia Butylated Hydroxytoluene 5.0111893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.662563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.662563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 11.9217616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.9217616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.6219131511
MESH:D011471 Prostatic Neoplasms trichostatin A 3.6219789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8116646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.5818551238
MESH:D012640 Seizures Phenobarbital 5.5811442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6317007042
MESH:D013274 Stomach Neoplasms decitabine 4.6319037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6318456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.6312958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.1719014326
MESH:D013964 Thyroid Neoplasms decitabine 16.1717967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.177505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 16.171399818
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8115213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.0211780464 12973940 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.0219087683 17616700
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1610091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014604 Uveal Neoplasms decitabine 4.7617785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00600 Sphingolipid metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37862
    • No data
    Releated disease ID Related disease Name
    PA445180Osteogenesis Imperfecta
    Releated drug ID Related drug Name
    PA449780glutathione
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00144 - Phosphatidylserine Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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