AutismKB 2.0

Annotation Detail for DHTKD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DHTKD1 ( DKFZp762M115,KIAA1630,MGC3090 )
Gene Full Name: dehydrogenase E1 and transketolase domain containing 1
Band: 10p14
Quick LinksEntrez ID:55526; OMIM: NA; Uniprot ID:DHTK1_HUMAN; ENSEMBL ID: ENSG00000181192; HGNC ID: 23537
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-50842-ketoglutarate dehydrogenase complex
PWY-5690TCA cycle variation III (eukaryotic)
No data
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DHTKD1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DHTKD1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DHTKD1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DHTKD1 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of DHTKD1 mRNAdecreases expression 20106945
D010634 Phenobarbital Phenobarbital results in increased expression of DHTKD1 mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.906195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.4317620307
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.3016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.3016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.303084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.3021507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.306705139 20007298 20935162 17173139 1701930
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6219416960 16109766 18713872 16227642 14725611 14986274 11739529 18071297 11461765 11834606 11743745 10915739 16781746 16081117 19420014 11287661 11421492 19739265 12594235 17906064 10774834 19085960 17562736 15968718 16393943 16177239 10663392 12705907 12153990 2444490 19164858 12392966 14550746 17522070 12958197 16485898 15619225 12540782 19923254 19370779 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D005234 Fatty Liver Cyclosporine 3.1819224547
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006529 Hepatomegaly Phenobarbital 3.9016109766
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.3418776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.9712371664
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008107 Liver Diseases Acetaminophen 4.1511587558 19784758 16610002 12969438 19014921 12587719 19460945 16611625
MESH:D008107 Liver Diseases Phenobarbital 4.1519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.067678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.0618177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 8.0621047994 8742319 19812893 19073162 19482888 15975961
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.966135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.968603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.9618308698 1399818 2563599 17172636 6150874
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5816965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.9412371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.942563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D012640 Seizures 2,4-dinitrotoluene 11.0418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.0418551238
MESH:D012640 Seizures Phenobarbital 11.043137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.291399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved