AutismKB 2.0

Annotation Detail for IL17RB


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Basic Information Top
Gene Symbol:IL17RB ( CRL4,EVI27,IL17BR,IL17RH1,MGC5245 )
Gene Full Name: interleukin 17 receptor B
Band: 3p21.1
Quick LinksEntrez ID:55540; OMIM: 605458; Uniprot ID:I17RB_HUMAN; ENSEMBL ID: ENSG00000056736; HGNC ID: 18015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031903 1-UFT protocol IL17RB protein results in increased susceptibility to 1-UFT protocolincreases response to substance 16734730
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of IL17RB mRNAdecreases expression 17547211
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of IL17RB mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IL17RB mRNAincreases expression 20106945
C110904 capecitabine IL17RB protein results in increased susceptibility to capecitabineincreases response to substance 16734730
D002857 Chromium Chromium results in decreased expression of IL17RB mRNAdecreases expression 17547211
D016572 Cyclosporine Cyclosporine results in decreased expression of IL17RB mRNAdecreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of IL17RB mRNAdecreases expression 17547211
C025034 doxifluridine IL17RB protein results in increased susceptibility to doxifluridineincreases response to substance 16734730
D008628 Mercury Mercury results in decreased expression of IL17RB mRNAdecreases expression 17547211
D017239 Paclitaxel IL17RB protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16734730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL17RB mRNAaffects binding|decreases expression|increases activity 19710929
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of IL17RB mRNAdecreases expression 17547211
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IL17RB mRNAincreases expression 20106945
D014303 Trinitrotoluene Trinitrotoluene affects the expression of IL17RB mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 14.677525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.6714514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 14.677525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5920127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.5916033868
MESH:D000236 Adenoma Benzo(a)pyrene 6.946695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.9419555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.0716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001321 Autistic Disorder Mercury 2.7817497416
MESH:D001327 Autoimmune Diseases Mercury 4.9116634805
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.6015867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3917474063 20146248
MESH:D001943 Breast Neoplasms capecitabine 2.3918473752 12972520
MESH:D001943 Breast Neoplasms Chromium 2.3915986119
MESH:D001943 Breast Neoplasms Paclitaxel 2.3916244791 16115903 18323546 18234424 16273361 18223236 15136595 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3920435547
MESH:D002277 Carcinoma Dimethylnitrosamine 8.4319555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4316835633
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 2.5316313753
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8320419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.8316033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4610334427
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.9514694615
MESH:D002386 Cataract Trinitrotoluene 7.9514694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 7.8319486331
MESH:D002779 Cholestasis pirinixic acid 7.8319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 8697196 12621046 15340226 15668235
MESH:D015179 Colorectal Neoplasms capecitabine 3.2518448328 18473752
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.2518802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 15.7615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 15.7614669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 15.7615095906
MESH:D003329 Coronary Vasospasm capecitabine 5.8417465463
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis Trinitrotoluene 4.9618551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.8816823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 7.8816823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.1421346803
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 9.148172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1420420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.1418551238 21346803
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4416530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 7.4417016578
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.4416481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 7.6619224547
MESH:D005234 Fatty Liver pirinixic acid 7.6619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly pirinixic acid 14.7416221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.7415340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 14.7415817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1115340226 16959395 8697196 18606429 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007248 Infertility, Male Trinitrotoluene 3.6912150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Chromium 14.7417934191
MESH:D007674 Kidney Diseases Cyclosporine 14.7410903974 8314463 18776723
MESH:D007674 Kidney Diseases Mercury 14.7417934191
MESH:D007674 Kidney Diseases Potassium Dichromate 14.7419665454
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7612371664
MESH:D008080 Liposarcoma Paclitaxel 4.8517353645
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 3.5017198567 18364076 15383259 15298665 17201889 17036385 16570917 17719030 16603200 17881167 14726149 18237412 18567088 17465448 17203207 17348192 15577212 15086199 17534399 15081153 15571005 18672772 15161499 15366600 15591649 15339415 14643895 18095165 15369754 14709902 15793283 17666798 15723089 15067225 15744066 14659978 18239293 17640959 15504291 12918455 16169303 16042886 16009107 15763062 18637143 15138612 18629640 15864749 17724770 17432682 15798949 15479170 14568256 16270385 16627068 15842777 17196135 15099470 15942678 15733078 16544323 15492853 18210741 18371158 12925901
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.4317457977
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.7820195826 21137059
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 10.7815890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 10.7816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7816984957
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 6.081848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.466695378 18816296 17053015 20464547 20135361 18569708 20869020 18520028 20064080
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 3.4616061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4611884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.1114749477
MESH:D008545 Melanoma Paclitaxel 2.5912040289 12025231 16342250
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.7114749477
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009336 Necrosis Trinitrotoluene 4.8218551238
MESH:D009362 Neoplasm Metastasis capecitabine 6.6012972520
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.6015867366
MESH:D009369 Neoplasms Benzo(a)pyrene 8.4711141357
MESH:D009369 Neoplasms capecitabine 8.4716374040
MESH:D009369 Neoplasms pirinixic acid 8.4717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.5514694615
MESH:D009784 Occupational Diseases Trinitrotoluene 9.5514694615 12819281 17852074
MESH:D010014 Osteolysis Paclitaxel 5.0315867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0011161223
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3917292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.3917136230 17172428 16729912 16356831
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures Trinitrotoluene 3.4618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5119755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5116192470
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.3312587719
MESH:D013163 Splenomegaly Trinitrotoluene 5.2415817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.522093021 20155912
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.5216033868
MESH:D013274 Stomach Neoplasms Paclitaxel 3.5218396642 18506536
MESH:D024801 Tauopathies Paclitaxel 4.8616930453
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29796
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA451581tamoxifen
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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