AutismKB 2.0

Annotation Detail for ENOSF1


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Basic Information Top
Gene Symbol:ENOSF1 ( HSRTSBETA,RTS,TYMSAS )
Gene Full Name: enolase superfamily member 1
Band: 18p11.32
Quick LinksEntrez ID:55556; OMIM: 607427; Uniprot ID:ENOF1_HUMAN; ENSEMBL ID: ENSG00000132199; HGNC ID: 30365
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ENOSF1 proteinaffects expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of ENOSF1 mRNAincreases expression 12875902
D005472 Fluorouracil ENOSF1 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D005472 Fluorouracil ENOSF1 protein results in decreased susceptibility to Fluorouracildecreases response to substance 18357371
C054474 manumycin manumycin affects the localization of ENOSF1 proteinaffects localization 18357371
C054474 manumycin manumycin results in decreased expression of ENOSF1 proteindecreases expression 18357371
D008727 Methotrexate ENOSF1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in increased expression of ENOSF1 mRNAincreases expression 12875902
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.7112039119
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D000740 Anemia Fluorouracil 4.0215504547 17963324 16511603
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 5.0717286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.0716292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9316197459 16206674
MESH:D001943 Breast Neoplasms Calcitriol 2.0711237771
MESH:D001943 Breast Neoplasms Fluorouracil 2.0718357371 15136595 18608205 19217205 16557594 16110121 16595493
MESH:D001943 Breast Neoplasms Methotrexate 2.0716978400
MESH:D001943 Breast Neoplasms Tretinoin 2.0716443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8712619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8717088986 16332177 17971768 17045692 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.871917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 8.0511237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 8.0516757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 8.0516051514 16096774
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2716340194 17725105 17018589 16510598 17172411 15001691 17169374 18772588 17016597 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016391804 20501625 18448328 17454858 17094418 15148649 17594712 16282729 17016601 16524972 17255274 18383874 18949393 18802399 18288408 16303861 16331619 17695437 17401013 18509181 14970324 15289873
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.0312039119 9562676
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.0310589399 9664655 17551590 9125849 9142499 8800419 16925845 14991402 9211117 9224671
MESH:D003550 Cystic Fibrosis Methotrexate 4.5419747007
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003882 Dermatomyositis Methotrexate 5.5120191521
MESH:D056486 Drug-Induced Liver Injury manumycin 4.3619739265
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5116337965 17638652 15173087 16785472 16481741
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006086 Graft vs Host Disease Methotrexate 5.5716518429
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.4718337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0414991402 9664655
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D007805 Language Development Disorders Methotrexate 5.459562676
MESH:D007938 Leukemia Tretinoin 2.9017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0219285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3417217047 19075265 16935935 17361223 17506722 16788101 17301526 17294898 19225113 17107899 17649720 16823087 19029980 17712046 17368321 19642359 16891316 17339181 12679006 15748426 16140955 9834237 16766008 19035177 16331271
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008103 Liver Cirrhosis Methotrexate 3.8514986274
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008113 Liver Neoplasms Aflatoxin B1 5.059163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Fluorouracil 5.0516603448 18383874 15113037 17045692
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.928603461
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.5418516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.6514755239
MESH:D008175 Lung Neoplasms Fluorouracil 2.6515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008223 Lymphoma Methotrexate 4.1717352296
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8718986760 16757204
MESH:D052016 Mucositis Methotrexate 5.7417488658
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009369 Neoplasms Fluorouracil 5.6118600527 16928823 18239605
MESH:D009369 Neoplasms Tretinoin 5.6116946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4216936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.6515113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3716644109 16289102 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3718626508 19082440
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011565 Psoriasis Methotrexate 3.5217410198
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Methotrexate 5.1317352296
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms Fluorouracil 2.5719015929 16424979 17172411 17522103 15786421 18396642 17498489 18567086 16951190 19084572
MESH:D013274 Stomach Neoplasms Tretinoin 2.5717261132
MESH:D013576 Syndactyly Methotrexate 5.429562676
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2617045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 10.8616280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.4816803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 10.4816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134897613
    • No data
    No data
    Releated drug ID Related drug Name
    PA449748gemcitabine
    PA128406956fluorouracil
    PA450428methotrexate
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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