Gene Symbol:	PLXNA3 ( 6.3,HSSEXGENE,PLEXIN-A3,PLXN3,PLXN4,SEX,XAP-6 )
Gene Full Name:	plexin A3
Band:	Xq28
Quick Links	Entrez ID:55558; OMIM: 300022; Uniprot ID:PLXA3_HUMAN; ENSEMBL ID: ENSG00000130827; HGNC ID: 9101
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
D016572	Cyclosporine	Cyclosporine results in increased expression of PLXNA3 mRNA	increases expression	20106945
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of PLXNA3 mRNA	increases expression	12634122
D013467	Sulindac	Sulindac results in increased expression of PLXNA3 mRNA	increases expression	11906190

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms	Sulindac	6.36	14745880
MESH:D058186	Acute Kidney Injury	Sulindac	4.80	7897758
MESH:D000230	Adenocarcinoma	Sulindac	3.19	11910360
MESH:D000236	Adenoma	Sulindac	4.00	10223192
MESH:D011125	Adenomatous Polyposis Coli	Sulindac	5.05	17611924 11535846 15623613 19003578 12394442 11874996 16460482
MESH:D001913	Bowen's Disease	Sulindac	6.22	11207687
MESH:D001943	Breast Neoplasms	Sulindac	3.11	16642371
MESH:D002471	Cell Transformation, Neoplastic	Cyclosporine	8.01	12371664
MESH:D002471	Cell Transformation, Neoplastic	Methylnitronitrosoguanidine	8.01	2727394
MESH:D002779	Cholestasis	Cyclosporine	3.24	19486331
MESH:D003110	Colonic Neoplasms	Sulindac	2.97	12458338 12902858
MESH:D015179	Colorectal Neoplasms	Sulindac	2.69	11076880 10666051 11197048 18059344
MESH:D003930	Diabetic Retinopathy	Sulindac	5.76	17621415 12861449
MESH:D004715	Endometriosis	Sulindac	4.92	15652904
MESH:D004938	Esophageal Neoplasms	Sulindac	3.22	12235107
MESH:D005234	Fatty Liver	Cyclosporine	3.34	19224547
MESH:D018221	Fibromatosis, Abdominal	Sulindac	6.22	14745880
MESH:D018222	Fibromatosis, Aggressive	Sulindac	5.87	19069698
MESH:D005355	Fibrosis	Cyclosporine	3.79	12639820 12168785
MESH:D005764	Gastroesophageal Reflux	Sulindac	5.59	11910360
MESH:D005885	Gingival Hyperplasia	Cyclosporine	4.96	8708960
MESH:D006457	Hemoglobinuria, Paroxysmal	Cyclosporine	5.16	15720958
MESH:D006973	Hypertension	Cyclosporine	2.23	10903974
MESH:D007249	Inflammation	Sulindac	3.50	3291741
MESH:D007414	Intestinal Neoplasms	Sulindac	5.08	12584176 10223192 12351151 10213222 12628509 12663524
MESH:D007417	Intestinal Polyps	Sulindac	5.52	11245490 12394442
MESH:D007638	Keratoconjunctivitis Sicca	Cyclosporine	5.31	15604871
MESH:D007674	Kidney Diseases	Cyclosporine	2.56	18776723 10903974 8314463
MESH:D007680	Kidney Neoplasms	Cyclosporine	3.12	12371664
MESH:D008105	Liver Cirrhosis, Biliary	Sulindac	4.47	12468960
MESH:D008107	Liver Diseases	Sulindac	3.11	14986274 16867024
MESH:D008175	Lung Neoplasms	Sulindac	2.70	19359593 15713900
MESH:D008545	Melanoma	Sulindac	2.87	16642371
MESH:D008664	Metal Metabolism, Inborn Errors	Cyclosporine	5.65	16801185
MESH:D053842	Microsatellite Instability	Methylnitronitrosoguanidine	6.63	17671175
MESH:D009402	Nephrosis, Lipoid	Cyclosporine	5.31	17954296
MESH:D009404	Nephrotic Syndrome	Cyclosporine	3.70	18481113 19348381
MESH:D019636	Neurodegenerative Diseases	Sulindac	4.66	16850258 17266991
MESH:D010146	Pain	Sulindac	4.17	3291741
MESH:D010190	Pancreatic Neoplasms	Sulindac	3.47	11504793 16820089
MESH:D011230	Precancerous Conditions	Cyclosporine	3.64	12371664
MESH:D011565	Psoriasis	Cyclosporine	2.34	16882103
MESH:D014594	Uterine Neoplasms	Sulindac	5.18	18645019
MESH:D014605	Uveitis	Cyclosporine	4.85	1336536
MESH:D014985	Xerophthalmia	Cyclosporine	5.31	17120751

Pathway ID	Pathway Name
KEGG:04360	Axon guidance
REACT:18266	Axon guidance

AutismKB 2.0

Annotation Detail for PLXNA3

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics