AutismKB 2.0

Annotation Detail for PRIM1


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Basic Information Top
Gene Symbol:PRIM1 ( MGC12308,p49 )
Gene Full Name: primase, DNA, polypeptide 1 (49kDa)
Band: 12q13.3
Quick LinksEntrez ID:5557; OMIM: 176635; Uniprot ID:PRI1_HUMAN; ENSEMBL ID: ENSG00000198056; HGNC ID: 9369
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa03030DNA replication
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
No data
Pathway IDPathway Name
P00017DNA replication
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PRIM1 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRIM1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRIM1 mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of PRIM1 mRNAincreases expression 16474171
D003345 Corticosterone Corticosterone results in decreased expression of PRIM1 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of PRIM1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of PRIM1 mRNAincreases expression 18503570
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PRIM1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of PRIM1 mRNA]decreases reaction|increases expression 17854601
D004958 Estradiol Estradiol results in increased expression of PRIM1 mRNAincreases expression 16474171
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of PRIM1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRIM1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRIM1 mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of PRIM1 mRNAincreases expression 15954086
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of PRIM1 mRNAaffects cotreatment|increases expression 17347304
D005472 Fluorouracil PRIM1 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D019833 Genistein Genistein results in increased expression of PRIM1 mRNAincreases expression 16474171
C010176 halofuginone halofuginone results in increased expression of PRIM1 mRNAincreases expression 17180598
C011890 kojic acid kojic acid results in decreased expression of PRIM1 mRNAdecreases expression 16595896
D008345 Manganese Manganese results in decreased expression of PRIM1 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of PRIM1 mRNAdecreases expression 17175027
D010126 Ozone Ozone results in increased expression of PRIM1 mRNAincreases expression 16716893
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PRIM1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PRIM1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of PRIM1 mRNAincreases expression 17950772
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PRIM1 mRNA]increases expression|increases reaction 17950772
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of PRIM1 mRNAincreases expression 16474171
C059514 resveratrol resveratrol results in decreased expression of PRIM1 mRNAdecreases expression 15767336
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PRIM1 mRNAdecreases expression 16714409
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRIM1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.1418926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.146195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.1415322242 11752688 14514962
MESH:D000138 Acidosis Ethanol 4.3011192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6816538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.0120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 13.0111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.0114692618
MESH:D000230 Adenocarcinoma Fluorouracil 13.0117638652
MESH:D000230 Adenocarcinoma Genistein 13.0111473722
MESH:D000236 Adenoma Benzo(a)pyrene 15.136695378
MESH:D000236 Adenoma Diethylnitrosamine 15.1310737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 15.136695378
MESH:D000236 Adenoma resveratrol 15.1315688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.2717620307 18056438 16434500 17162532 19061943 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.2716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.2716835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1315451039 15451040
MESH:D000544 Alzheimer Disease Ozone 4.2315513908
MESH:D000544 Alzheimer Disease resveratrol 4.2316162502 16183991
MESH:D000740 Anemia Fluorouracil 8.1317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000756 Anemia, Sideroblastic Manganese 10.4516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.4516910769
MESH:D000853 Anophthalmos Ethanol 4.6315513904
MESH:D001008 Anxiety Disorders Ethanol 3.8511141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9715885639
MESH:D001169 Arthritis, Experimental resveratrol 6.9717115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5817854713 16373670
MESH:D050197 Atherosclerosis resveratrol 3.1617967414 16873680
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7114991843
MESH:D002545 Brain Ischemia resveratrol 4.0917600658
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1215144691 18412241 16651633 16357521 16436596
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.6417474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 5.6417123778
MESH:D001943 Breast Neoplasms Dietary Fats 5.6420435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6417474063
MESH:D001943 Breast Neoplasms Estradiol 5.6417289903 17018787 12948864 16675129 18497071 17261762 19861407 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 5.6419217205 18357371 16557594 16595493 15136595 18608205 16110121
MESH:D001943 Breast Neoplasms Genistein 5.6416873071 17200150 16541309
MESH:D001943 Breast Neoplasms resveratrol 5.6417651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5316777450 15516495 18315731 19059883 18417511 17626835 14754758
MESH:D002056 Burns Ethanol 4.4616374292
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4816051944
MESH:D002277 Carcinoma Fluorouracil 7.6917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.3816705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.3818210153 19335982 18506893 19171122 18393292 18494052 16540662 17978847 19052882 17138121 16328049 10737359 16830150 17173139 18788625 17761372 19919837 16779866 16569478 20101231 16502159 19418558 18978308 20432363 10672840 16807293 20727157 20512989 16878318 20935162 19208518 18971187 19701751 18691550 16935385 19822196 20514400 21159647 19539802 19107877 17055752 17162532 20214788 19383236 3084413 16698587 16681979 19519916 19394651 18785209 20084675 16288022 20524982 18665156 3581430 11831363 17428255 18056438 20007298
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 16.3815763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.3817045692 16799960 17088986 18930000 16332177 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 16.381701930 20935162 17173139 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.3816227395 19321006
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4016675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2516280240 18986760 16757204 17066447
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.2516227395
MESH:D006332 Cardiomegaly Ethanol 6.5019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 7.0816332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.0815458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 24.676135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 24.6720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 24.6712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 24.6717174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 24.6718566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 24.6716003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7917160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis Cyclosporine 12.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5317681005 16919318 17110522 16105132 15861022 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 12.5319176532
MESH:D002971 Cleft Lip Ethanol 3.4915513904
MESH:D002972 Cleft Palate Ethanol 5.6915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.698697196 15668235 16354765 12621046 15340226
MESH:D003092 Colitis resveratrol 3.9416474422
MESH:D003110 Colonic Neoplasms Fluorouracil 5.6818772588 16340194 15001691 17169374 17725105 17016597 16510598 17287894 17172411 17018589
MESH:D003110 Colonic Neoplasms Genistein 5.6817182828
MESH:D003110 Colonic Neoplasms resveratrol 5.6816338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5117401013 20501625 18288408 16524972 16303861 18802399 17255274 17695437 15289873 18448328 17594712 16282729 18949393 16331619 14970324 16391804 18383874 17094418 17016601 18509181 15148649 17454858
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.5115531428
MESH:D015179 Colorectal Neoplasms resveratrol 3.5116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6316507316
MESH:D019465 Craniofacial Abnormalities Ethanol 2.5710194807 11873399 11198716 15451039 15451040 19302082 15513904
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5710048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8318551238
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5316140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6116873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8220387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.8216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8217107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.4819279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.4816286809
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.5119107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.5111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7918357618
MESH:D004487 Edema pirinixic acid 10.4412083418
MESH:D004487 Edema resveratrol 10.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.5112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.5117872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.4016402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.1011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.1011473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8610568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6617923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.0020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.0016530937
MESH:D004938 Esophageal Neoplasms Ethanol 10.0016704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.0016481741 15173087 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Cyclosporine 34.3219224547
MESH:D005234 Fatty Liver Dietary Fats 34.3218296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 34.3220387270 21071580
MESH:D005234 Fatty Liver Ethanol 34.3218620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.3215345470
MESH:D005234 Fatty Liver Fish Oils 34.3218620774
MESH:D005234 Fatty Liver pirinixic acid 34.3219236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4717920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1115451040 15513904 10194807 16946407
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005355 Fibrosis Cyclosporine 13.6212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6220067830
MESH:D005756 Gastritis Ethanol 4.5015046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Ethylnitrosourea 11.4116436596
MESH:D005909 Glioblastoma Genistein 11.4116598420
MESH:D005909 Glioblastoma Manganese 11.4117043766
MESH:D005910 Glioma Ethylnitrosourea 6.1016357521 18412241 16651633
MESH:D005910 Glioma Fluorouracil 6.1016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2615102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006529 Hepatomegaly Phenobarbital 13.2916109766
MESH:D006529 Hepatomegaly pirinixic acid 13.2919772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006561 Herpes Simplex resveratrol 3.9916876885
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Ethanol 3.5718783367
MESH:D006937 Hypercholesterolemia Dietary Fats 8.6421332399
MESH:D006937 Hypercholesterolemia resveratrol 8.6417188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006949 Hyperlipidemias Dietary Fats 14.5621332399
MESH:D006949 Hyperlipidemias Fish Oils 14.5615752949
MESH:D006949 Hyperlipidemias resveratrol 14.5616873680
MESH:D006965 Hyperplasia halofuginone 5.0611874485
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.3111484837
MESH:D006973 Hypertension Cyclosporine 4.7010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Dietary Fats 11.1520412841
MESH:D007249 Inflammation Diethylnitrosamine 11.1518785209
MESH:D007249 Inflammation resveratrol 11.1516366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1512200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.3516624496
MESH:D007333 Insulin Resistance bisphenol A 16.6216393666
MESH:D007333 Insulin Resistance Dietary Fats 16.6211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.6216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 16.6216306350
MESH:D007569 Jaw Abnormalities Ethanol 9.5415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 5.578314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.5715618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 21.6916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 21.6912371664
MESH:D007680 Kidney Neoplasms Estradiol 21.6915610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 21.6917379185
MESH:D007680 Kidney Neoplasms Fluorouracil 21.6916985049
MESH:D007859 Learning Disorders Ethanol 4.0215451040
MESH:D007938 Leukemia Genistein 2.9318980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4516087638
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6817676605
MESH:D008103 Liver Cirrhosis Dietary Fats 19.6518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 19.6519638242 20032147 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Ethanol 19.6515289165
MESH:D008103 Liver Cirrhosis halofuginone 19.6517180598
MESH:D008103 Liver Cirrhosis Phenobarbital 19.6521047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9018295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.4318166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.4317823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 8.4312175628 11172339 14739098 16489207 18458672
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4312878042
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9417034775
MESH:D008107 Liver Diseases Phenobarbital 3.9419363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4617347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.707678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.7021137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7016942905 15175105 2422723 20101389 19090486 18754104 20492335 18977376 12112319 21278145 20118626 19426721 12771043 19642983 19551842 20583210 19812893 19499222 19427195 21167192 10737359 2862719 20501860 21071580 19256749 19294768 18978307 19638242 9163691 19690152 20405173 19996281 21047994 19255062 20434301 18648771 20137499 19254457 19833225 18644402 20452335 15885732 19073162 19850985
MESH:D008113 Liver Neoplasms Fluorouracil 24.7017045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms Phenobarbital 24.7019812893 15975961 8742319 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 24.7016377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 24.7019073162 19321006 19812893 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.842876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.8419009564 18253720 18282651 18093689 19519916 18164116 9362446 17174075 18308698 18775883 19539802 2563599 16842330 17942915 16267830 19126423 21159647 19004024 18544905 3124819 17854601 18079962
MESH:D008114 Liver Neoplasms, Experimental kojic acid 21.8418544905
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.8417172636 18308698 1399818 6150874 2563599
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 21.841423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.8412151625
MESH:D008171 Lung Diseases Ozone 3.2519066396 8266340
MESH:D055370 Lung Injury Ozone 3.6620417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2418816296 20135361 20464547 20869020 18569708 17053015 20064080 18520028 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2420970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Ethylnitrosourea 8.246695378 17703301 16019985 16271038
MESH:D008175 Lung Neoplasms Fluorouracil 8.2415246190
MESH:D008175 Lung Neoplasms Ozone 8.247614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008223 Lymphoma Ethylnitrosourea 3.8115790496
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7114749477
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8615375218
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0615688416
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 17.5712807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.5716891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 17.5710838139 18041768 10767621
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.5714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 17.578985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 12.3619453300
MESH:D020149 Manganese Poisoning Manganese 12.3616568477 19453300 16551646
MESH:D008545 Melanoma resveratrol 2.3417992120
MESH:D008569 Memory Disorders Ethanol 4.0018411066 15451040
MESH:D008579 Meningioma Ethylnitrosourea 5.7917943659
MESH:D008659 Metabolic Diseases resveratrol 4.2017112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0516381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.0518986760 16757204
MESH:D009069 Movement Disorders Manganese 4.8316551646
MESH:D009101 Multiple Myeloma resveratrol 3.3317049120 16490592 14749477 16267019 17935668 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009203 Myocardial Infarction Genistein 9.0417141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.0419151258
MESH:D009203 Myocardial Infarction resveratrol 9.0417125593 17188708 17015251 16525036 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 8.5117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.3316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.3317141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.3316411023
MESH:D009205 Myocarditis resveratrol 4.5717322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.6718551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.499029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6711141357
MESH:D009369 Neoplasms Fluorouracil 7.6716928823 18239605 18600527
MESH:D009369 Neoplasms pirinixic acid 7.6717405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.8716707424
MESH:D009374 Neoplasms, Experimental resveratrol 8.878985016
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.1316551646
MESH:D009421 Nervous System Malformations bisphenol A 21.9311399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 21.9311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 21.9316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.9314600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2217160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0120387270
MESH:D019636 Neurodegenerative Diseases resveratrol 8.0117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009765 Obesity Dietary Fats 4.2717217161 20132043 20518802 11836018 19632207 16723640 18674790 21332399 18457598
MESH:D009765 Obesity pirinixic acid 4.2720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.2616049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7917160924
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010024 Osteoporosis Genistein 3.1419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.5616169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.5617513867
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.7019401270
MESH:D010051 Ovarian Neoplasms Genistein 4.7019005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7916540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.7912384795
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.7916929163 16500647 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.7916965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010300 Parkinson Disease Manganese 5.7011181820
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.7016702228
MESH:D020734 Parkinsonian Disorders Manganese 4.3016140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D011014 Pneumonia Ozone 4.2018007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.3412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.342563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.342563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.1810548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.1816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.1811896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0718626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.0716925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.0715721890
MESH:D011471 Prostatic Neoplasms resveratrol 2.0717804756 17718901 17675339 16731767 17636462 15767336
MESH:D011537 Pruritus Ethinyl Estradiol 3.1216919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8518722050 16160472 15538739 18286688
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3916325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2619058328
MESH:D015427 Reperfusion Injury resveratrol 6.2617058453 17520802 15827377 16314181 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012640 Seizures 2,6-dinitrotoluene 9.1518551238
MESH:D012640 Seizures Ethanol 9.159754883
MESH:D012640 Seizures Phenobarbital 9.153137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012871 Skin Diseases halofuginone 3.4611874485
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9210029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 8.928985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7516709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5820155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5818456281
MESH:D013274 Stomach Neoplasms Ethanol 4.5818456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.5819015929 17522103 18396642 17172411 16424979 18567086 16951190 15786421 19084572 17498489
MESH:D013276 Stomach Ulcer Ethanol 3.369211565 9562338 17918041 17189318 11906479 16755016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3116321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.099754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9715790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.701399818
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.4316280240
MESH:D014062 Tongue Neoplasms resveratrol 9.4316227395
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.7216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7217053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1310091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.0516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.0517473185
MESH:D014591 Uterine Diseases bisphenol A 4.8214652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8914692618
MESH:D014594 Uterine Neoplasms resveratrol 8.8917044934
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
REACT:383 DNA Replication
KEGG:03030 DNA replication
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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