AutismKB 2.0

Annotation Detail for STAB2


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Basic Information Top
Gene Symbol:STAB2 ( DKFZp434E0321,FEEL2,FELE-2,FELL2,FEX2,HARE )
Gene Full Name: stabilin 2
Band: 12q23.3
Quick LinksEntrez ID:55576; OMIM: 608561; Uniprot ID:STAB2_HUMAN; ENSEMBL ID: ENSG00000136011; HGNC ID: 18629
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of STAB2 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of STAB2 mRNAdecreases expression 18042831
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of STAB2 mRNAaffects cotreatment|increases expression 17183730
C041786 palm oil palm oil results in decreased expression of STAB2 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of STAB2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of STAB2 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of STAB2 mRNAaffects binding|decreases expression|increases activity 19710929
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of STAB2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4816434500
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 16609825 17507914 19460635 17157402 18396377 18316065 18177632 18558336 18775368 15238991 19232924 18985861 18940202 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.986705139 1701930 20935162 17173139 20007298
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0111287661 17906064 12392966 19085960 10774834 19923254 11529661 11834606 12705907 16177239 16781746 12594235 16485898 14986274 18713872 16109766 14725611 11421492 11461765 19164858 11739529 12958197 19420014 2444490 19370779 16081117 11743745 16227642 10663392 17522070 18071297 15968718 17562736 14550746 19416960 15619225 12540782 12153990 19739265 10915739 16393943
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.011733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D004421 Dystonia Phenobarbital 11.471851702
MESH:D004421 Dystonia Valproic Acid 11.471851702
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 12.023659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 12.023659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 11.503922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 11.503922381 16628512
MESH:D004827 Epilepsy Phenobarbital 7.0820417680
MESH:D004827 Epilepsy Valproic Acid 7.0818234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.706401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.706426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.537750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.537750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.843659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.843659116
MESH:D005234 Fatty Liver Dietary Fats 14.8218296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver pirinixic acid 14.8219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 14.8214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly Phenobarbital 9.7016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.7019772884 16221962 19176532 18467677
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9816612254
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8211836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008103 Liver Cirrhosis Dietary Fats 7.1218296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1221047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1319460945 12969438 12587719 19784758 16610002 16611625 19014921 11587558
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7619812893 15975961 8742319 19073162 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 4.7620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.861399818 17172636 2563599 18308698 6150874
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Dietary Fats 4.6211836018 18674790 21332399 19632207 20518802 17217161 16723640 18457598 20132043
MESH:D009765 Obesity pirinixic acid 4.6220558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D019310 Pseudolymphoma Phenobarbital 13.7112752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.7112752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Phenobarbital 6.6116876388 3137016 4039156 11442880
MESH:D012640 Seizures Valproic Acid 6.6115475178 16876388 11738929 11044598 17978042 14763951 1511512 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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