AutismKB 2.0

Annotation Detail for MIOX


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Basic Information Top
Gene Symbol:MIOX ( ALDRL6,MGC90217 )
Gene Full Name: myo-inositol oxygenase
Band: 22q13.33
Quick LinksEntrez ID:55586; OMIM: 606774; Uniprot ID:MIOX_HUMAN; ENSEMBL ID: ENSG00000100253; HGNC ID: 14522
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa00053Ascorbate and aldarate metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MIOX mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of MIOX mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MIOX mRNAaffects expression 16483693
D007294 Inositol [MIOX protein binds to Iron] which binds to Inositolaffects binding 17012379
D007501 Iron [MIOX protein binds to Iron] which binds to Inositolaffects binding 17012379
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MIOX mRNAincreases expression 16267337
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 6.1216640825
MESH:D000544 Alzheimer Disease Iron 3.0616640825 16563566
MESH:D000740 Anemia Iron 9.9516434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.9511748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.9516569441 17375513 17162259 17163184 17147795
MESH:D000756 Anemia, Sideroblastic Iron 5.1416910769
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001145 Arrhythmias, Cardiac Iron 4.6716604332
MESH:D001260 Ataxia Telangiectasia Iron 5.9115336622
MESH:D050197 Atherosclerosis Iron 3.8816640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.5818445737
MESH:D001321 Autistic Disorder Inositol 2.5816818868
MESH:D001321 Autistic Disorder Iron 2.5817352947
MESH:D001424 Bacterial Infections Iron 5.6616640825
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 16120746 18850075
MESH:D009202 Cardiomyopathies Iron 4.2416640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.5416604332
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 16354765 15340226 12621046
MESH:D003110 Colonic Neoplasms Iron 2.9316640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D002658 Developmental Disabilities Inositol 5.9316818868
MESH:D003920 Diabetes Mellitus Iron 4.7416640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.4316506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.7616506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.572444490 12958197 11529661 10915739 16393943 11743745 19164858 19085960 11421492 11739529 12392966 16781746 15619225 18071297 16485898 11834606 17562736 14986274 19370779 11461765 12594235 16081117 10663392 17906064 19923254 14725611 18713872 19416960 10774834 15968718 12153990 16109766 19420014 16177239 17522070 19739265 14550746 11287661 12540782 12705907 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Iron 4.4116640825
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005621 Friedreich Ataxia Iron 5.8516604332 16640825
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006432 Hemochromatosis Iron 4.7116640825 17236123 16574947 17255318 16604332 17053826
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006486 Hemosiderosis Iron 5.7316604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.9916640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.3617182432
MESH:D006529 Hepatomegaly Iron 10.1716890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.1712621046 15340226 16120746
MESH:D015658 HIV Infections Iron 3.8116597321
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007006 Hypogonadism Iron 4.6116640825
MESH:D007037 Hypothyroidism Iron 5.5016640825
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D019189 Iron Metabolism Disorders Iron 5.3917163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D020961 Lewy Body Disease Iron 5.8516563566
MESH:D008103 Liver Cirrhosis Iron 3.8816640825
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 12587719 19784758 16610002 19460945 11587558 19014921 16611625
MESH:D008108 Liver Diseases, Alcoholic Iron 5.4216737972 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Iron 5.0620302851 16640825
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 5.0616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Iron 2.6616640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6619555203 11884234
MESH:D008268 Macular Degeneration Iron 4.1316640825
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 6.1917086897
MESH:D009181 Mycoses Iron 5.9916640825
MESH:D017202 Myocardial Ischemia Iron 10.0316604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 10.0312213967
MESH:D015428 Myocardial Reperfusion Injury Iron 4.5116604332
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009404 Nephrotic Syndrome Iron 4.8017178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.4218514411
MESH:D019636 Neurodegenerative Diseases Iron 9.4216604332 17296847
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7316049721 12819281
MESH:D010003 Osteoarthritis Iron 4.1416640825
MESH:D010024 Osteoporosis Iron 4.0316640825 16648989
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010212 Papilloma Iron 4.9012065085
MESH:D020447 Parasomnias Iron 6.5417352947
MESH:D010300 Parkinson Disease Iron 3.4116563566 16640825
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010900 Pituitary Diseases Iron 6.1916604332
MESH:D011041 Poisoning Iron 4.6416604332
MESH:D017119 Porphyria Cutanea Tarda Iron 12.3216640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 12.3218163543
MESH:D011225 Pre-Eclampsia Iron 4.6616640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11118676 11896295 11399792
MESH:D011528 Protozoan Infections Iron 6.5416640825
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012148 Restless Legs Syndrome Iron 4.7816930377
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
MESH:D012878 Skin Neoplasms Iron 6.3012065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.3016192470
MESH:D013398 Sudden Infant Death Iron 5.9116640825
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D014376 Tuberculosis Iron 4.2616597321
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:00053 Ascorbate and aldarate metabolism
KEGG:00562 Inositol phosphate metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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