AutismKB 2.0

Annotation Detail for OTUD5


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Basic Information Top
Gene Symbol:OTUD5 ( DKFZp761A052,DUBA,MGC104871 )
Gene Full Name: OTU domain containing 5
Band: Xp11.23
Quick LinksEntrez ID:55593; OMIM: 300713; Uniprot ID:OTUD5_HUMAN; ENSEMBL ID: ENSG00000068308; HGNC ID: 25402
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04622RIG-I-like receptor signaling pathway
No data
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of OTUD5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of OTUD5 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of OTUD5 mRNAaffects expression 17555576
D007657 Ketone Bodies Ketone Bodies results in increased expression of OTUD5 mRNAincreases expression 16807920
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OTUD5 mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of OTUD5 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1817893378 17261762 17049068 20005174 19011961 18425577 19487384 19066611 17440819 16273361 11161223 19200415 16873071 20390343 19221464 21138602 18855134 19059307 18815881 19244106 19115204 18821012 15565566 19142967 19155303 17242785 18351453 20859285 20544844 18629630 20135344 18997820 15668708 18984771 19189210 19410462 19189212 16818667 19084267 19103187 20065188 21152245 19289846 19288272 16202921
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5217333356 16919318 17110522 16105132 15861022 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 8.5219176532
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9716393943 12958197 11421492 15968718 12594235 14986274 12392966 19085960 17522070 19416960 19164858 17906064 19923254 14725611 19370779 11739529 10663392 18713872 16485898 16109766 15619225 16781746 2444490 16081117 17562736 11834606 12540782 12705907 11529661 19739265 19420014 16227642 14550746 11287661 12153990 11743745 10774834 18071297 11461765 10915739 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2419155303 16202921 17893378 20544844
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0115345470
MESH:D005234 Fatty Liver pirinixic acid 15.0119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 15.0114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 19772884 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2916705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2918625569
MESH:D008064 Lipidoses Tamoxifen 3.3715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4018564211
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16611625 19460945 12587719 16610002 11587558 12969438 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.987678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.9815890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.9816684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.726135515 2876786 2876784
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8111731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3816049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3817572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
Pathway ID Pathway Name
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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