AutismKB 2.0

Annotation Detail for FAM46A


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Basic Information Top
Gene Symbol:FAM46A ( C6orf37,FLJ20037,FLJ31495,XTP11 )
Gene Full Name: family with sequence similarity 46, member A
Band: 6q14.1
Quick LinksEntrez ID:55603; OMIM: 611357; Uniprot ID:FA46A_HUMAN; ENSEMBL ID: ENSG00000112773; HGNC ID: 18345
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FAM46A proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FAM46A mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of FAM46A mRNAdecreases expression 20106945
D002945 Cisplatin FAM46A protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D005047 Etoposide FAM46A protein affects the susceptibility to Etoposideaffects response to substance 16217747
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of FAM46A mRNAaffects cotreatment|increases expression 17183730
D016685 Mitomycin FAM46A protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D010634 Phenobarbital Phenobarbital results in increased expression of FAM46A mRNAincreases expression 19482888
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of FAM46A mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of FAM46A mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of FAM46A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.336195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.338875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D058186 Acute Kidney Injury Cisplatin 4.1315814532 17670903 12690470
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 4.6517638652 11798837
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.2117620307
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.3217497229
MESH:D001008 Anxiety Disorders vinclozolin 9.3219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 15238991 18177632 18316065 17688650 20603192 16609825 17507914 18775368 18396377 18940202 19232924 19460635 18985861 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 13.1314601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 13.1314601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0620146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 2.0619526202 18382427
MESH:D001943 Breast Neoplasms Etoposide 2.0616322251
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8312619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8317982673
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8317173139 6705139 20935162 20007298 1701930
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0912023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9120419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.916189445 17066447 18337622
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.211733752 19641884
MESH:D004362 Drug Toxicity Cisplatin 3.9812649298 19839026 12231392 15033597
MESH:D004421 Dystonia Phenobarbital 11.061851702
MESH:D004421 Dystonia Valproic Acid 11.061851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.523659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 11.523659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 10.8811558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 10.8816628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.9320417680
MESH:D004827 Epilepsy Valproic Acid 6.9318234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 9.386401628
MESH:D004832 Epilepsy, Absence Valproic Acid 9.387562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 12.037750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 12.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.293659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 11.293659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7416530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.7417638652 15173087 15464296 16481741 16785472
MESH:D005234 Fatty Liver Cyclosporine 8.3319224547
MESH:D005234 Fatty Liver Valproic Acid 8.3319224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.3612168785 12639820
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8215464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.4519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.5615464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006529 Hepatomegaly Phenobarbital 3.7016109766
MESH:D006561 Herpes Simplex Etoposide 4.8010809021
MESH:D006689 Hodgkin Disease Cisplatin 8.3216200630 16170182
MESH:D006689 Hodgkin Disease Etoposide 8.3217606976 18180244 15147373 16135485 16200630
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.4115464296
MESH:D007674 Kidney Diseases Cisplatin 6.4912231392 12649298 19839026 18289764 15190930
MESH:D007674 Kidney Diseases Cyclosporine 6.498314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.0611231351
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.2515890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2521137059 20195826
MESH:D008113 Liver Neoplasms Mitomycin 11.2515113037
MESH:D008113 Liver Neoplasms Phenobarbital 11.2519812893 19073162 21047994 15975961 8742319 19482888
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.368603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.361399818 6150874 17172636 2563599 18308698
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6018569708 20064080 18520028 20135361 18816296 20869020 20464547 17053015 6695378
MESH:D008175 Lung Neoplasms Cisplatin 3.606189445 11798837 17225452
MESH:D008223 Lymphoma Etoposide 4.0412854902 12556972
MESH:D008545 Melanoma Cisplatin 2.4912883367 16432458 18332650 16248763 18176117 16809738 11135225 17023156 12393984 17761969 15577323 12374674 18505091
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.0115990972
MESH:D008654 Mesothelioma Cisplatin 3.3017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4411141357
MESH:D009369 Neoplasms Cisplatin 5.4416773208
MESH:D009395 Nephritis, Interstitial Cisplatin 4.7615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 3.538761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.938761367
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9219769630 15464296 6897625 17225452
MESH:D010190 Pancreatic Neoplasms Cisplatin 12.9019003803
MESH:D010190 Pancreatic Neoplasms Etoposide 12.9019003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 12.9015113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 12.9016965848
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.6117638057
MESH:D011230 Precancerous Conditions Cyclosporine 9.4812371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.482563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5320603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.5319015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4117292933
MESH:D011471 Prostatic Neoplasms Etoposide 3.4117172428
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D019310 Pseudolymphoma Phenobarbital 13.0912752131
MESH:D019310 Pseudolymphoma Valproic Acid 13.0912752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D051437 Renal Insufficiency Cisplatin 4.6215464296
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 11.2914601052
MESH:D012512 Sarcoma, Ewing's Etoposide 11.2914601052
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Phenobarbital 6.383137016 11442880 16876388 4039156
MESH:D012640 Seizures Valproic Acid 6.3817978042 15475178 1511512 16876388 11044598 11738929 3137016 14763951
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.6115464296
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.582093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 2.5818396642 15958060 17522103
MESH:D013736 Testicular Neoplasms Cisplatin 4.8117225452 15464296
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.181399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4117053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.4112973940 15464296 17225452
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.3716803524
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.8215577323
MESH:D014839 Vomiting Cisplatin 4.9811897121
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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