AutismKB 2.0

Annotation Detail for KIF21A


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Basic Information Top
Gene Symbol:KIF21A ( CFEOM1,DKFZp779C159,FEOM1,FEOM3A,FLJ20052,KIAA1708 )
Gene Full Name: kinesin family member 21A
Band: 12q12
Quick LinksEntrez ID:55605; OMIM: 608283; Uniprot ID:KI21A_HUMAN; ENSEMBL ID: ENSG00000139116; HGNC ID: 19349
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Fibrosis of extraocular muscles, congenital, 3B
Fibrosis of extraocular muscles, congenital, 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of KIF21A mRNAaffects expression 18343893
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KIF21A mRNAaffects expression 21346803
D001241 Aspirin Aspirin results in increased expression of KIF21A mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KIF21A mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIF21A mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of KIF21A mRNAincreases expression 20106945
C121718 dicyclanil dicyclanil results in increased expression of KIF21A mRNAincreases expression 15664270
D004041 Dietary Fats Dietary Fats results in increased expression of KIF21A mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF21A mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in increased expression of KIF21A mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of KIF21A mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF21A mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KIF21A mRNAdecreases expression 17337447
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KIF21A mRNAincreases expression 18691609
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 11.1517162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.1516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8120485159 12372130
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001932 Brain Neoplasms Aspirin 4.5515481559
MESH:D001943 Breast Neoplasms Aspirin 1.9915161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9917474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.4916705839
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 3.4917162532
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.696135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1216105132 17333356 17681005 17110522 16919318 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 12621046 8697196 16354765 15668235
MESH:D003110 Colonic Neoplasms Aspirin 3.0012411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.8221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema Aspirin 7.5217259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 13.9019224547
MESH:D005234 Fatty Liver Dietary Fats 13.9017967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 15.7812168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.7818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.7820067830
OMIM:135700 FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 1 marker/mechanism
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Aspirin 4.0412870263
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006261 Headache Aspirin 5.1815240983
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 11.6511294989
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.6520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.6510048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 18606429 8697196 16959395 16354765
MESH:D012001 Hyperacusis Aspirin 5.9815240983
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Dietary Fats 5.1420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.1918457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.147678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1421137059 20195826
MESH:D008113 Liver Neoplasms dicyclanil 11.1420118626
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.012876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2220064080 18816296 6695378 18569708 20869020 20464547 17053015 18520028 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2219555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D008881 Migraine Disorders Aspirin 4.1615240983
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009203 Myocardial Infarction Aspirin 3.6012692751
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009325 Nausea Aspirin 5.4315240983
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.057678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009765 Obesity Dietary Fats 2.3116723640 21332399 20132043 17217161 18457598 18674790 20518802 11836018 19632207
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010003 Osteoarthritis Aspirin 4.147009135
MESH:D010146 Pain Aspirin 3.976363464 6995502
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.7311156591
MESH:D020795 Photophobia Aspirin 5.9815240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012220 Rhinitis Aspirin 4.5012372130
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.4412269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Aspirin 4.4916403987
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Aspirin 9.6217672075
MESH:D013927 Thrombosis Ethinyl Estradiol 9.6215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Aspirin 4.5920485159 10982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134882934
    • No data
    Releated disease ID Related disease Name
    PA443690Charcot-Marie-Tooth Disease
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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