AutismKB 2.0

Annotation Detail for PRKAA1


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Basic Information Top
Gene Symbol:PRKAA1 ( AMPK,AMPKa1,MGC33776,MGC57364 )
Gene Full Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Band: 5p13.1
Quick LinksEntrez ID:5562; OMIM: 602739; Uniprot ID:AAPK1_HUMAN; ENSEMBL ID: ENSG00000132356; HGNC ID: 9376
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa04140Regulation of autophagy
hsa05410Hypertrophic cardiomyopathy (HCM)
Pathway IDPathway Name
Activated AMPK stimulates fatty-acid oxidation in muscle
Signaling by Insulin receptor
No data
Pathway IDPathway Name
P04397p53 pathway by glucose deprivation
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C078219 1,2,3,4,7,8-hexachlorodibenzodioxin 1,2,3,4,7,8-hexachlorodibenzodioxin results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 15703265
C495818 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 21186350
C438505 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
C438505 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16873680
C473217 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 19167487
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 16837613
C031143 AICA ribonucleotide PRKAA1 gene mutant form inhibits the reaction [FSHB protein affects the reaction [AICA ribonucleotide results in increased phosphorylation of MAPK1 protein]]affects reaction|decreases reaction|increases phosphorylation 16837613
C031143 AICA ribonucleotide PRKAA1 protein affects the reaction [AICA ribonucleotide affects the reaction [FSHB protein results in increased secretion of Progesterone]]affects reaction|increases secretion 16837613
C031143 AICA ribonucleotide PRKAA1 protein affects the reaction [FSHB protein affects the reaction [AICA ribonucleotide results in increased expression of STAR protein]]affects reaction|increases expression 16837613
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16873680
C031143 AICA ribonucleotide AICA ribonucleotide results in increased activity of PRKAA1 proteinincreases activity 12519745
C031143 AICA ribonucleotide AICA ribonucleotide results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 16020477
C031143 AICA ribonucleotide [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesteronedecreases secretion|increases phosphorylation 16020477
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased phosphorylation of PRKAA1 proteindecreases phosphorylation 16990341
D013196 Dihydrotestosterone Estradiol inhibits the reaction [Dihydrotestosterone results in decreased phosphorylation of PRKAA1 protein]decreases phosphorylation|decreases reaction 16990341
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKAA1 mRNAaffects expression 16483693
D047310 Apigenin Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of PRKAA1 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKAA1 mRNAdecreases expression 19150397
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of PRKAA1 mRNAincreases expression 17553608
C542815 BLX 1002 BLX 1002 results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 19052259
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRKAA1 mRNAaffects expression 12734012
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of PRKAA1 mRNAincreases expression 17452286
C018021 cobaltous chloride cobaltous chloride results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16678800
C018021 cobaltous chloride PRKAA1 protein affects the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]affects reaction|increases expression 16678800
C018021 cobaltous chloride PRKAA1 protein affects the reaction [cobaltous chloride results in increased secretion of VEGFA protein]affects reaction|increases secretion 16678800
D003474 Curcumin Curcumin results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 18790744
D003976 Diazinon Diazinon results in increased expression of PRKAA1 mRNAincreases expression 17452286
D004958 Estradiol Estradiol inhibits the reaction [Dihydrotestosterone results in decreased phosphorylation of PRKAA1 protein]decreases phosphorylation|decreases reaction 16990341
D004958 Estradiol Estradiol results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 15967841
D005419 Flavonoids Flavonoids results in decreased expression of PRKAA1 mRNAdecreases expression 18035473
D005576 Forskolin Forskolin results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 18390901
D005576 Forskolin PNPLA2 protein affects the reaction [Forskolin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]affects reaction|increases activity|increases phosphorylation 18390901
D005947 Glucose 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
D005947 Glucose Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
D005947 Glucose Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 proteindecreases activity|decreases phosphorylation 16873680
D005947 Glucose Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
D005947 Glucose resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
D005947 Glucose Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 proteindecreases activity|decreases phosphorylation 19052259
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases expression|increases phosphorylation 15297373
C051890 irinotecan irinotecan analog results in decreased expression of PRKAA1 mRNAdecreases expression 18927307
D015056 1-Methyl-3-isobutylxanthine 1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 18390901
D015056 1-Methyl-3-isobutylxanthine orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 18390901
D007545 Isoproterenol Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 18390901
D007545 Isoproterenol orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 18390901
D007545 Isoproterenol triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 18390901
D007545 Isoproterenol INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]decreases reaction|increases phosphorylation 19167487
D007545 Isoproterenol Isoproterenol results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 19167487
D007545 Isoproterenol N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]decreases reaction|increases phosphorylation 19167487
D007545 Isoproterenol OPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]]decreases reaction|increases phosphorylation 19167487
D007545 Isoproterenol orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]decreases reaction|increases phosphorylation 19167487
D007545 Isoproterenol [PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]affects cotreatment|decreases reaction|increases phosphorylation 19167487
D008687 Metformin Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
D008687 Metformin Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16873680
D008687 Metformin Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 19052259
D008687 Metformin 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 21186350
D008687 Metformin Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 21186350
D008687 Metformin Metformin results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSH protein results in increased expression of HSD3B protein]]decreases reaction|increases expression 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSH protein results in increased expression of STAR protein]]decreases reaction|increases expression 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSH protein results in increased phosphorylation of PRKAA1 protein]]decreases reaction|increases phosphorylation|increases reaction 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]decreases expression|decreases reaction 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]decreases reaction|decreases secretion 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 16760380
D008687 Metformin PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]decreases reaction|increases phosphorylation 16760380
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]decreases reaction|increases phosphorylation 19167487
C060853 OPC 3911 OPC 3911 inhibits the reaction [INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]]decreases reaction|increases phosphorylation 19167487
C055122 orlistat orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 18390901
C055122 orlistat orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 18390901
C055122 orlistat orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]decreases reaction|increases phosphorylation 19167487
C006253 pirinixic acid pirinixic acid results in increased expression of PRKAA1 mRNAincreases expression 19236843
D011374 Progesterone PRKAA1 protein affects the reaction [AICA ribonucleotide affects the reaction [FSHB protein results in increased secretion of Progesterone]]affects reaction|increases secretion 16837613
D011374 Progesterone [AICA ribonucleotide results in increased phosphorylation of PRKAA1 protein] which results in decreased secretion of Progesteronedecreases secretion|increases phosphorylation 16020477
D011374 Progesterone PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]decreases reaction|decreases secretion 16760380
C059514 resveratrol resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]decreases activity|decreases phosphorylation|decreases reaction 16873680
C059514 resveratrol resveratrol results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16873680
C059514 resveratrol resveratrol results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 17464184
C059514 resveratrol resveratrol results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 17438283
C059514 resveratrol STK11 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA1 protein]increases phosphorylation|increases reaction 17438283
D012402 Rotenone Rotenone results in increased expression of PRKAA1 mRNAincreases expression 17651460
C017947 sodium arsenite PRKAA1 protein affects the reaction [sodium arsenite results in increased expression of HIF1A protein]affects reaction|increases expression 16678800
C017947 sodium arsenite PRKAA1 protein affects the reaction [sodium arsenite results in increased expression of VEGFA mRNA]affects reaction|increases expression 16678800
C017947 sodium arsenite PRKAA1 protein affects the reaction [sodium arsenite results in increased secretion of VEGFA protein]affects reaction|increases secretion 16678800
C017947 sodium arsenite sodium arsenite results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16678800
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased phosphorylation of PRKAA1 proteinincreases phosphorylation 15703265
C034613 triacsin C triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]decreases reaction|increases activity|increases phosphorylation 18390901
D014415 Tunicamycin Tunicamycin results in decreased expression of PRKAA1 mRNAdecreases expression 17127020
D014638 Vanadates PRKAA1 protein affects the reaction [Vanadates results in increased expression of HIF1A protein]affects reaction|increases expression 16678800
D014638 Vanadates PRKAA1 protein affects the reaction [Vanadates results in increased expression of VEGFA mRNA]affects reaction|increases expression 16678800
D014638 Vanadates PRKAA1 protein affects the reaction [Vanadates results in increased secretion of VEGFA protein]affects reaction|increases secretion 16678800
D014638 Vanadates Vanadates results in increased phosphorylation of and results in increased activity of PRKAA1 proteinincreases activity|increases phosphorylation 16678800
15297373
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D058186 Acute Kidney Injury resveratrol 3.5016538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7618653653
MESH:D000230 Adenocarcinoma Estradiol 2.0011473722
MESH:D000236 Adenoma resveratrol 3.0915688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5016712894 17306315
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.8711874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.8716487989
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6817887948
MESH:D000544 Alzheimer Disease Curcumin 4.1115590663
MESH:D000544 Alzheimer Disease resveratrol 4.1116162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D001169 Arthritis, Experimental resveratrol 3.2617115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6416807698
MESH:D050197 Atherosclerosis Curcumin 6.1218704882
MESH:D050197 Atherosclerosis resveratrol 6.1217967414 16873680
MESH:D001327 Autoimmune Diseases Curcumin 4.1119761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5115746008
MESH:D001919 Bradycardia Isoproterenol 4.796740701
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9417868700
MESH:D001930 Brain Injuries Progesterone 3.8715845082 15380490 15665606
MESH:D002545 Brain Ischemia Curcumin 9.0116770732
MESH:D002545 Brain Ischemia resveratrol 9.0117600658
MESH:D001932 Brain Neoplasms Curcumin 3.6017596214
MESH:D001943 Breast Neoplasms Apigenin 2.7517132221 16541309
MESH:D001943 Breast Neoplasms Curcumin 2.7516243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Estradiol 2.7512948864 17289903 19861407 17018787 18497071 14630087 16675129 17261762
MESH:D001943 Breast Neoplasms Progesterone 2.7516175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 2.7516393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7520435547
MESH:D019121 Burkholderia Infections orlistat 6.2417874328
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4010355542 16050911 16227642 16097048 15700767 18705752 15673190 16192424 15721981 16011737 3786805 16124888
MESH:D002277 Carcinoma Curcumin 7.2618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.0018788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0016924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.0019321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.0015276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2016675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8318414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 6.9118462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.9116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.9118572023
MESH:D006332 Cardiomegaly Isoproterenol 6.377544033 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3716120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.6816936243
MESH:D002318 Cardiovascular Diseases resveratrol 6.6815458977
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.6220889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.6218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.6220056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8316835633
MESH:D002779 Cholestasis pirinixic acid 2.5419176532
MESH:D002916 Chylothorax orlistat 6.2417003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9315340226 8697196 16354765 12621046 15668235
MESH:D003092 Colitis Curcumin 8.5216782535 16804969 18200517
MESH:D003092 Colitis resveratrol 8.5216474422
MESH:D003103 Coloboma Curcumin 4.2018809619
MESH:D003110 Colonic Neoplasms Curcumin 5.4719359593 16340194
MESH:D003110 Colonic Neoplasms irinotecan 5.4717725105 17287894
MESH:D003110 Colonic Neoplasms resveratrol 5.4716338953
MESH:D015179 Colorectal Neoplasms irinotecan 2.7117454858 16391804 16303861 17159606 18509181 15273666 18259882
MESH:D015179 Colorectal Neoplasms resveratrol 2.7116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5118497527
MESH:D003327 Coronary Disease resveratrol 3.5016507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.6715059100 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D048909 Diabetes Complications orlistat 5.4419207292
MESH:D003920 Diabetes Mellitus Metformin 4.9917446233
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4516873680
MESH:D003924 Diabetes Mellitus, Type 2 BLX 1002 9.5419052259
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.5418403477
MESH:D003924 Diabetes Mellitus, Type 2 Metformin 9.5421186350
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.5417107852
MESH:D003925 Diabetic Angiopathies Metformin 5.6516385087
MESH:D003928 Diabetic Nephropathies Curcumin 13.1918204486
MESH:D003928 Diabetic Nephropathies Estradiol 13.1919279558
MESH:D003928 Diabetic Nephropathies resveratrol 13.1916286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.1117187935
MESH:D003967 Diarrhea orlistat 4.3520002075
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.3116227642 15027814 7120509 7179309 7440962 10092053 4309450 2869522 17522070 6884620 15968718 6623471 16177239 11566570 9327722 15998439 10915739 21278145 3786805 19336974 19085960 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6817351913
MESH:D004417 Dyspnea Diazinon 4.4016487989
MESH:D004487 Edema pirinixic acid 9.4212083418
MESH:D004487 Edema resveratrol 9.428985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.4212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.1017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.1017872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.7218566989 19148513 11473722
MESH:D004715 Endometriosis Progesterone 7.8016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.809294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4617923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 1.9720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.1412795759 16239168 15959796 61145 17595544 19224547 12631006 16045604
MESH:D005234 Fatty Liver Curcumin 11.1419297423
MESH:D005234 Fatty Liver pirinixic acid 11.1419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 12.6018705752
MESH:D005355 Fibrosis Curcumin 12.6018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6020067830
MESH:D005414 Flatulence orlistat 6.2420002075
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2816452187
MESH:D005909 Glioblastoma Curcumin 3.2217596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.3918829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1210048152 11294989
MESH:D006333 Heart Failure Isoproterenol 6.5618097624
MESH:D006333 Heart Failure pirinixic acid 6.5620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.3719900420 19110552
MESH:D006505 Hepatitis Diazinon 8.3716487989
MESH:D006529 Hepatomegaly pirinixic acid 6.9916221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9916120746 12621046 15340226
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6517701891
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006561 Herpes Simplex resveratrol 3.7916876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.8312676792
MESH:D019584 Hot Flashes Estradiol 3.3517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6415340226 8697196 18606429 16354765 16959395
MESH:D017588 Hyperandrogenism Metformin 5.5915356085 17062894
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006937 Hypercholesterolemia Curcumin 8.2218704882
MESH:D006937 Hypercholesterolemia resveratrol 8.2217188708
MESH:D006943 Hyperglycemia BLX 1002 8.9419052259
MESH:D006943 Hyperglycemia pirinixic acid 8.9420558911
MESH:D006949 Hyperlipidemias orlistat 8.6321332399
MESH:D006949 Hyperlipidemias resveratrol 8.6316873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D006984 Hypertrophy Isoproterenol 4.8412791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9617488730
MESH:D007022 Hypotension Isoproterenol 4.446740701
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.0418306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.2015869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.2017600658
MESH:D007248 Infertility, Male Diazinon 6.2516466525 12948887
MESH:D007248 Infertility, Male sodium arsenite 6.2512646999 15346721
MESH:D007249 Inflammation Curcumin 13.6116956363 18403477 17151092
MESH:D007249 Inflammation Flavonoids 13.6117296493
MESH:D007249 Inflammation Progesterone 13.6115869954
MESH:D007249 Inflammation resveratrol 13.6116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.6112200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0418200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.1416624496
MESH:D007333 Insulin Resistance Estradiol 15.6516393666 16627594
MESH:D007333 Insulin Resistance Metformin 15.6517062894
MESH:D007333 Insulin Resistance orlistat 15.6517201808
MESH:D007333 Insulin Resistance pirinixic acid 15.6516306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.8810783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.0418306037
MESH:D007674 Kidney Diseases Estradiol 5.3415618244
MESH:D007674 Kidney Diseases sodium arsenite 5.3420008137
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.2417185156
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.9216518626
MESH:D007680 Kidney Neoplasms Estradiol 2.6715610895
MESH:D007889 Leiomyoma Curcumin 4.2118555241
MESH:D007938 Leukemia Curcumin 3.0418462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8516106398
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3216087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.3916106398
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4316239168 16943688 17157831 11408273 21278145 16221502 17334410 17174718 11903743
MESH:D008103 Liver Cirrhosis orlistat 6.4317404856
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.1114724832 12632512 18481824 12546737 14512876 15996030 17708605 17721639 18277467 16097048 15370692 15818738 18166357 18279442 18054572 15959796 18705752 16011737 15931870 17714472 17922224 18418968 18210741 18156304 18006644 18420326 17565644 15052691 17823541 17631135 16248980 18429990 15893842 18251166 17698563 15876570 12445418 18263696 12389079 18205269 16638106 17976157 16015684 12898905 14716496 12741479 15650968 16033810 15338365 18339082 18412020 17557913 16116963 18187930 17805973 12445421 14620537 12667390 12666154 18395095 16136751 13678700 14748882 14716833 11481614 16027843 15057751 15362042 15673190 10355542 17481882 16192424 17869086 17900296 18472332 17640975 12632514 12609069 15730626 12958196 20821823 18376398 15925388 17766677 17761835 12586293 17944888 17525996 18317297 15123356 12649538 18395914 18472094
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 6.1117355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.1114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.1112878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0616246199 16964402 17285989 15720792 15830285
MESH:D008107 Liver Diseases Chlorpyrifos 6.0615991261
MESH:D008107 Liver Diseases Curcumin 6.0616956363
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.5119294768
MESH:D008113 Liver Neoplasms pirinixic acid 12.5116377806 15890375 20007298
MESH:D008113 Liver Neoplasms resveratrol 12.5119812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 12.5115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.5116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 4.9415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 4.9412151625
MESH:D008171 Lung Diseases sodium arsenite 2.9119095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.6417365036
MESH:D008175 Lung Neoplasms Curcumin 3.1716243823 19359593 18462866
MESH:D008175 Lung Neoplasms sodium arsenite 3.1716712894 19931552 17306315 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.1719555203 11884234
MESH:D008207 Lymphatic Metastasis orlistat 5.5118770866 20805790
MESH:D008223 Lymphoma Curcumin 3.3118462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3116173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.8515688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.5517203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.5511408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.558985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D008545 Melanoma Curcumin 8.9617885582 18462866
MESH:D008545 Melanoma Glucose 8.9614993021
MESH:D008545 Melanoma orlistat 8.9618770866 20805790
MESH:D008545 Melanoma resveratrol 8.9617992120
MESH:D008545 Melanoma sodium arsenite 8.9619082730 16487513
MESH:D008569 Memory Disorders Curcumin 3.7817263510
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0216166281 16966607 18303189
MESH:D008659 Metabolic Diseases resveratrol 4.0217112576
MESH:D052016 Mucositis irinotecan 4.6117159606
MESH:D009101 Multiple Myeloma Curcumin 6.6419372569
MESH:D009101 Multiple Myeloma resveratrol 6.6417935668 14749477 16490592 17164350 17049120 16267019
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.1017962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.1017962980
MESH:D009135 Muscular Diseases orlistat 9.4618430571
MESH:D009135 Muscular Diseases pirinixic acid 9.4616239165
MESH:D009164 Mycobacterium Infections orlistat 5.0921442799
MESH:D009203 Myocardial Infarction Isoproterenol 8.6117052832 16538859 19595682 19172585 16584858 15740881 16697266
MESH:D009203 Myocardial Infarction pirinixic acid 8.6119151258
MESH:D009203 Myocardial Infarction resveratrol 8.6116525036 17015251 17188708 16317513 17125593 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.9817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2516411023
MESH:D009205 Myocarditis resveratrol 4.3617322642
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0018495463
MESH:D009362 Neoplasm Metastasis irinotecan 3.0118259882
MESH:D009369 Neoplasms orlistat 7.2518710210
MESH:D009369 Neoplasms pirinixic acid 7.2517405874
MESH:D009369 Neoplasms sodium arsenite 7.2511559025
MESH:D009374 Neoplasms, Experimental orlistat 13.2619381703
MESH:D009374 Neoplasms, Experimental resveratrol 13.268985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.2620056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.1312497104
MESH:D009389 Neovascularization, Pathologic Estradiol 9.1817289903
MESH:D009389 Neovascularization, Pathologic orlistat 9.1817012255
MESH:D009410 Nerve Degeneration Rotenone 3.5817356569 15790535 18619942
MESH:D009421 Nervous System Malformations Estradiol 8.2211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2214600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.2318462866
MESH:D009436 Neural Tube Defects sodium arsenite 2.8912854658
MESH:D009447 Neuroblastoma irinotecan 3.278761367
MESH:D019636 Neurodegenerative Diseases resveratrol 3.4917652729
MESH:D017599 Neuroectodermal Tumors irinotecan 4.348761367
MESH:D020078 Neurogenic Inflammation resveratrol 4.0417929310
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9015081274
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.2117404856
MESH:D009765 Obesity Curcumin 6.9819297423
MESH:D009765 Obesity orlistat 6.9820518802 21438711 19046740 18773755 16938137 19461584 20599501 21442799 20002075 20540997 19207292 20065556
MESH:D009765 Obesity pirinixic acid 6.9820558911
MESH:D010024 Osteoporosis Curcumin 3.2318719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8917513867
MESH:D010051 Ovarian Neoplasms Curcumin 10.1818462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 10.1819401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.1817393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.1817306315 15276417
MESH:D010190 Pancreatic Neoplasms Curcumin 2.7919401701 19196508 17440100
MESH:D010195 Pancreatitis orlistat 4.4916938137 20065556
MESH:D010212 Papilloma Hydrogen Peroxide 3.7112065085
MESH:D010300 Parkinson Disease Rotenone 2.8316412576 19232380 16140633 15451049 18619942 11445065 18191903 19114014 11535288
MESH:D020734 Parkinsonian Disorders Rotenone 3.7415795934 18197244 15574749 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5110923243
MESH:D011041 Poisoning Diazinon 3.9917603234
MESH:D011085 Polycystic Ovary Syndrome Metformin 9.8417062894 15356085
MESH:D011085 Polycystic Ovary Syndrome orlistat 9.8417201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.2816679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2811118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms Apigenin 1.9317132221
MESH:D011471 Prostatic Neoplasms Curcumin 1.9311398177 12497104 15129424 18769126 10851300 18156803 18226269
MESH:D011471 Prostatic Neoplasms Estradiol 1.9316740699
MESH:D011471 Prostatic Neoplasms resveratrol 1.9315767336 17675339 17718901 17804756 16731767 17636462
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9316039940
MESH:D011654 Pulmonary Edema Isoproterenol 4.8510903255
MESH:D011656 Pulmonary Emphysema Curcumin 4.1919168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.8717365031 15814490 17975199 17322281
MESH:D012035 Refsum Disease orlistat 5.6820871815
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1816325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.9019058328
MESH:D015427 Reperfusion Injury resveratrol 5.9017058453 16314181 15827377 16317513 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6710666014 18379247
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2516611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4916611668 17119214
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7118045962
MESH:D012509 Sarcoma Curcumin 3.7818462866
MESH:D018805 Sepsis Curcumin 3.7518389075
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.696418539
MESH:D012878 Skin Neoplasms Glucose 15.8814993021
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 15.8812065085
MESH:D012878 Skin Neoplasms resveratrol 15.8815837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 15.8818572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.8816192470
MESH:D013119 Spinal Cord Injuries Progesterone 3.8916503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4912854658
MESH:D013274 Stomach Neoplasms irinotecan 3.0815723263
MESH:D013274 Stomach Neoplasms orlistat 3.0819381703
MESH:D013276 Stomach Ulcer Curcumin 3.1619188055 16631530
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1416321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5012697716
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8716227395
MESH:D001749 Urinary Bladder Neoplasms Curcumin 4.7718593936
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.7716712894 11723127 17306315 16452187
MESH:D014565 Urogenital Neoplasms Curcumin 4.8718462866
MESH:D014570 Urologic Diseases Diazinon 4.8716487989
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.4317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.4311813266
MESH:D014594 Uterine Neoplasms resveratrol 3.7617044934
MESH:D014652 Vascular Diseases sodium arsenite 4.0317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 9.3918097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.3917488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.2918097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
Pathway ID Pathway Name
REACT:11163 Activated AMPK stimulates fatty-acid oxidation in muscle
KEGG:04920 Adipocytokine signaling pathway
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
KEGG:04910 Insulin signaling pathway
KEGG:04150 mTOR signaling pathway
KEGG:04140 Regulation of autophagy
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33744
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA164744376adenosine monophosphate
    PA164743471adenosine triphosphate
    PA449773glucose
    PA450911phenobarbital
    PA451283rosiglitazone
    PA450970pioglitazone
    PA450395metformin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00131 - Adenosine monophosphate Dietary supplement;Micronutrient
    DB00171 - Adenosine triphosphate Dietary supplement;Micronutrient
    DB00914 activator Phenformin Hypoglycemic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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