AutismKB 2.0

Annotation Detail for PRKACA


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Basic Information Top
Gene Symbol:PRKACA ( MGC102831,MGC48865,PKACA )
Gene Full Name: protein kinase, cAMP-dependent, catalytic, alpha
Band: 19p13.1
Quick LinksEntrez ID:5566; OMIM: 601639; Uniprot ID:KAPCA_HUMAN; ENSEMBL ID: ENSG00000072062; HGNC ID: 9380
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa05414Dilated cardiomyopathy
hsa05146Amoebiasis
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04962Vasopressin-regulated water reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04742Taste transduction
hsa04340Hedgehog signaling pathway
hsa04740Olfactory transduction
hsa04062Chemokine signaling pathway
hsa05020Prion diseases
hsa04210Apoptosis
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Metabolism of carbohydrates
Cell Cycle, Mitotic
Diabetes pathways
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Signaling in Immune system
Metabolism of lipids and lipoproteins
Integration of energy metabolism
Pathway IDPathway Name
200036LPA4-mediated signaling events
200070Signaling events mediated by HDAC Class I
200134Syndecan-1-mediated signaling events
200151VEGFR1 specific signals
200015GMCSF-mediated signaling events
200159Calcium signaling in the CD4+ TCR pathway
200069Thromboxane A2 receptor signaling
200142Retinoic acid receptors-mediated signaling
200061LKB1 signaling events
200077Glucocorticoid receptor regulatory network
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200169Class I PI3K signaling events mediated by Akt
200166Aurora A signaling
200164Syndecan-2-mediated signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200147Hedgehog signaling events mediated by Gli proteins
200119ErbB2/ErbB3 signaling events
200117Paxillin-dependent events mediated by a4b1
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04377Beta1 adrenergic receptor signaling pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P00028Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
P04386Histamine H2 receptor mediated signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00041Metabotropic glutamate receptor group I pathway
Pathway IDPathway Name
500841DARPP-32 events
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of PRKACA mRNAincreases expression 16014739
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PRKACA mRNAdecreases expression 18648102
D000242 Cyclic AMP 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [[arsenite results in decreased abundance of Cyclic AMP] which results in decreased activity of PRKACA protein]decreases abundance|decreases activity|decreases reaction 18309289
D000242 Cyclic AMP [arsenite results in decreased abundance of Cyclic AMP] which results in decreased activity of PRKACA proteindecreases abundance|decreases activity 18309289
C061133 Am 80 Am 80 results in increased expression of PRKACA mRNAincreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKACA mRNAaffects expression 16483693
C015001 arsenite 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [[arsenite results in decreased abundance of Cyclic AMP] which results in decreased activity of PRKACA protein]decreases abundance|decreases activity|decreases reaction 18309289
C015001 arsenite [arsenite results in decreased abundance of Cyclic AMP] which results in decreased activity of PRKACA proteindecreases abundance|decreases activity 18309289
C015001 arsenite arsenite results in increased expression of PRKACA mRNAincreases expression 18191166
D001194 Asbestos Asbestos affects the expression of PRKACA mRNAaffects expression 17297452
C065179 atorvastatin atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA proteinincreases activity|increases phosphorylation 19053045
C065179 atorvastatin N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein]decreases reaction|increases activity|increases phosphorylation 19053045
D015124 8-Bromo Cyclic Adenosine Monophosphate 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [[arsenite results in decreased abundance of Cyclic AMP] which results in decreased activity of PRKACA protein]decreases abundance|decreases activity|decreases reaction 18309289
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKACA mRNAaffects cotreatment|decreases expression 20360939
D002976 Clenbuterol Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]decreases phosphorylation|decreases reaction 16339297
D003024 Clozapine Clozapine results in increased expression of PRKACA mRNAincreases expression 15860345
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKACA mRNAaffects cotreatment|decreases expression 20360939
D004280 Dobutamine Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]decreases phosphorylation|decreases reaction 16339297
D004317 Doxorubicin Doxorubicin results in increased expression of PRKACA mRNAincreases expression 16404146
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal results in decreased expression of PRKACA proteindecreases expression 17895526
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRKACA mRNAincreases expression 17942748
D005576 Forskolin Forskolin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]decreases phosphorylation|decreases reaction 16339297
D006220 Haloperidol Haloperidol results in increased expression of PRKACA mRNAincreases expression 15860345
D016627 Oxidopamine Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]decreases phosphorylation|decreases reaction 16339297
D016627 Oxidopamine Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]decreases phosphorylation|decreases reaction 16339297
D016627 Oxidopamine Forskolin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein]decreases phosphorylation|decreases reaction 16339297
D016627 Oxidopamine Oxidopamine results in decreased phosphorylation of PRKACA proteindecreases phosphorylation 16339297
C057416 KT 5720 KT 5720 inhibits the reaction [PRKACA protein results in increased phosphorylation of SNAP25 protein]decreases reaction|increases phosphorylation 14766180
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein]decreases reaction|increases activity|increases phosphorylation 19053045
D011374 Progesterone Progesterone results in decreased activity of PRKACA proteindecreases activity 15456849
C017947 sodium arsenite sodium arsenite results in decreased expression of PRKACA mRNAdecreases expression 12760830
C017947 sodium arsenite sodium arsenite results in increased expression of PRKACA mRNAincreases expression 16014739
C017947 sodium arsenite sodium arsenite results in decreased expression of PRKACA proteindecreases expression 12760830
C025462 sulindac sulfide sulindac sulfide results in increased expression of PRKACA mRNAincreases expression 16184548
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKACA mRNAincreases expression 15667827
17407152
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 14514962 11752688
MESH:D000038 Abscess Drugs, Chinese Herbal 6.1015043669
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D000230 Adenocarcinoma Doxorubicin 4.2117418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.273712494
MESH:D000236 Adenoma Diethylnitrosamine 6.2710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.3516434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6917306315 16712894
MESH:D000380 Agranulocytosis Clozapine 4.8512649775 14617031 16160616
MESH:D000419 Albuminuria Doxorubicin 4.3421441931
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0418759972
MESH:D000740 Anemia Drugs, Chinese Herbal 8.4217963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 5.2111477813
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.7515043669
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.5519655406
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7016819260
MESH:D050197 Atherosclerosis Am 80 7.2316484594
MESH:D050197 Atherosclerosis Asbestos 7.2318795166
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.5114699433
MESH:D001321 Autistic Disorder Haloperidol 2.7618080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.811440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4914601052
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.639881647
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.6317150277
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Doxorubicin 1.9319526202 15136595 16264153 15668708 18628466 16935488 16096432 15567936 18695136 15994142 18234424 16322301 16595493 17369602 15939500 15993339 15692762 16115903 17983394 17426702 18382427 15634643 16826403 11325840
MESH:D001943 Breast Neoplasms Progesterone 1.9316175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.313581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.3118788625 19519916 16878318 18506893 20727157 20084675 3084413 3581430 19107877 20007298 20101231 17428255 16569478 18785209 19383236 18978308 18210153 17978847 10672840 16288022 16681979 16540662 17055752 16807293 17162532 19394651 20214788 19335982 16935385 21159647 20514400 19822196 19701751 11831363 18971187 17173139 19919837 19171122 19418558 17761372 19208518 16698587 18393292 16779866 20432363 20524982 18056438 20935162 10737359 17138121 18494052 16830150 16502159 19052882 18665156 18691550 16328049 19539802 20512989
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.3116234567 17876044 18059187 16023760
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.3117306315 15276417 16507464
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3812391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.227296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.2216201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.616189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.6118572023
MESH:D006332 Cardiomegaly atorvastatin 6.8318360054
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8318850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3916109756 17329180 16952015 16651473 16278810 16364871 15811867 16731534 16269455 15476868 15505089 17308081 17351982 16455267 15792986 16242529 17007740 17519947 17924179 17131338 17382496 18627295 17928571 17974986 16612575
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8717334414 16243910
MESH:D002375 Catalepsy Haloperidol 4.701977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.397505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3917174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.3920056578 19524636
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.359022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3517681005 16919318 11677210 15861022 17110522 16105132 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0215668235 16354765 8697196 12621046 15340226
MESH:D003072 Cognition Disorders Clozapine 4.7617123785
MESH:D003110 Colonic Neoplasms arsenite 2.5515037631
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D003324 Coronary Artery Disease atorvastatin 4.0716368305
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.6520210726
MESH:D003704 Dementia Haloperidol 4.3911575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6112868966 8970840 2524372 11298694 18759878 11906362 8156756 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.303621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.8616402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.8620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8617107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3415331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.359022650 1440618 11289319 16192314 18692083 18289764 18648102 7440962 8291058 9653073 6679447 9328219 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.3519107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.3517416283
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 11.3515027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.3520420201
MESH:D004362 Drug Toxicity Doxorubicin 7.6018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6011462148
MESH:D050171 Dyslipidemias Clozapine 4.0316402076
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6918230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 14.3616819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.3612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.3617692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3217359293
MESH:D004715 Endometriosis Progesterone 8.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.329294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9418037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.063581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver arsenite 12.0918296743
MESH:D005234 Fatty Liver Diethylnitrosamine 12.0920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3819069698
MESH:D005355 Fibrosis arsenite 8.1318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1320067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4716452187
MESH:D005909 Glioblastoma Doxorubicin 3.2217150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3915692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2210048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3417875725 16707910 14766674 16144979 16879835 16495754 16244372 12587719 16244371 18006777 18674790 16330681 17888722
MESH:D006333 Heart Failure atorvastatin 11.5216360360
MESH:D006333 Heart Failure Dobutamine 11.5217440445
MESH:D006333 Heart Failure Doxorubicin 11.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7115692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.006705139
MESH:D006505 Hepatitis Drugs, Chinese Herbal 9.0018339527
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6916120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 6.9018501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.9012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316959395 15340226 16354765 8697196 18606429
MESH:D006937 Hypercholesterolemia atorvastatin 4.8911583720
MESH:D006948 Hyperkinesis Clozapine 4.7016046005
MESH:D006938 Hyperlipoproteinemia Type II atorvastatin 4.9916238680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7315034207
MESH:D006973 Hypertension atorvastatin 5.3717042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1817937319
MESH:D007248 Infertility, Male sodium arsenite 6.1812646999 15346721
MESH:D007249 Inflammation atorvastatin 11.1316908763
MESH:D007249 Inflammation Diethylnitrosamine 11.1318785209
MESH:D007249 Inflammation Progesterone 11.1315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1312878042 12200463
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4010783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 9.5915369732
MESH:D007674 Kidney Diseases Doxorubicin 9.5915369732 16775033 15699352
MESH:D007674 Kidney Diseases sodium arsenite 9.5920008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9616707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.806582329
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9416085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.8415802533
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 8.0216819260 16531727
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.0216766008
MESH:D008064 Lipidoses Clozapine 3.8117567588
MESH:D008103 Liver Cirrhosis arsenite 10.5918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.5918665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 10.5917163593
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.079327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental atorvastatin 4.8817347453
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 4.8817881167 12632512 15849816 16610055 17629604 18237412 15641146 15383259 15339415 18606216 15864749 18371158 15763062 18567088 17348192 15744066 17666798 15818738 17036385 15754396
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8812878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3317034775
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 4.3317207593
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.0919426721 19638242 15885732 19642983 19690152 20137499 18977376 12771043 20501860 2862719 18644402 21047994 2422723 19073162 20118626 19812893 19850985 20452335 19294768 19499222 15175105 19427195 20434301 10737359 19551842 20583210 19254457 20492335 18978307 19255062 19090486 9163691 18754104 20405173 20101389 19996281 18648771 16942905 19833225 21167192 21071580 19256749 21278145 12112319
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 10.0918339527
MESH:D008113 Liver Neoplasms sodium arsenite 10.0915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.0916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.056587162 1399818 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.0518308698 2563599 18282651 17854601 3124819 16267830 16842330 19004024 18544905 19539802 18079962 17174075 18164116 18775883 19126423 19009564 18093689 21159647 17942915 18253720 19519916 9362446
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 13.0516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.0512151625
MESH:D008133 Long QT Syndrome Dobutamine 4.5819353679
MESH:D008171 Lung Diseases Dobutamine 7.4816638327
MESH:D008171 Lung Diseases sodium arsenite 7.4819095001
MESH:D008175 Lung Neoplasms arsenite 10.3016809336
MESH:D008175 Lung Neoplasms Asbestos 10.3012111688
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.3020970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 10.306189445 17418594
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 10.3018339527
MESH:D008175 Lung Neoplasms sodium arsenite 10.3017077188 16712894 19931552 15276417 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3011884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3615621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.4315458769
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 9.4314758024
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.4317203775 11408345
MESH:D008545 Melanoma Doxorubicin 3.3516827129
MESH:D008545 Melanoma sodium arsenite 3.3519082730 16487513
MESH:D001523 Mental Disorders Clozapine 7.6716856516
MESH:D001523 Mental Disorders Haloperidol 7.6716856516
MESH:D008654 Mesothelioma Asbestos 6.4916564556 18709470 18310086 16919927 16319530
MESH:D008654 Mesothelioma Doxorubicin 6.4917638057
MESH:D024821 Metabolic Syndrome X Clozapine 4.2419142101
MESH:D020326 Migraine without Aura Cyclic AMP 4.9511304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3115792986
MESH:D052016 Mucositis Doxorubicin 4.5817415656
MESH:D009101 Multiple Myeloma Am 80 4.3817229644
MESH:D009135 Muscular Diseases atorvastatin 5.2616239165
MESH:D009203 Myocardial Infarction Doxorubicin 2.8615857846 19429709
MESH:D017202 Myocardial Ischemia Dobutamine 8.8412447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8412213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.033581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.033581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.0318259882
MESH:D009369 Neoplasms sodium arsenite 2.4011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4620056578
MESH:D009389 Neovascularization, Pathologic arsenite 4.2015738583
MESH:D009401 Nephrosis Doxorubicin 4.5616636307 16899518
MESH:D009404 Nephrotic Syndrome atorvastatin 9.3919348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.3915640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.816679447
MESH:D009436 Neural Tube Defects sodium arsenite 6.8112854658
MESH:D009447 Neuroblastoma Doxorubicin 3.1615555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3120387270
MESH:D019636 Neurodegenerative Diseases Oxidopamine 8.3118514411
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9020387270
MESH:D009765 Obesity Clozapine 2.9719142110 18515891
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.244026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 4.7916548355
MESH:D012516 Osteosarcoma Doxorubicin 3.9515930896
MESH:D010051 Ovarian Neoplasms Progesterone 4.7316525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.7315276417 17306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.2511771942 15893579
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9417983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9417638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.382563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811118676 11222880 11399792 11896295
MESH:D011471 Prostatic Neoplasms Am 80 2.8816289102
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.8818437689 15897917 15749863 16729912 16868541 16888761
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.8816039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D011565 Psoriasis Am 80 4.0216819260
MESH:D011595 Psychomotor Agitation Haloperidol 4.7511575062
MESH:D011618 Psychotic Disorders Clozapine 8.6615331141
MESH:D011618 Psychotic Disorders Haloperidol 8.6611575062
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 3.6416987627
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.7515043669
MESH:D051437 Renal Insufficiency Doxorubicin 4.0117922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.223692021
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 5.0615015336
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012509 Sarcoma Doxorubicin 3.8115625365 17203757 16767912 17710206 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0414601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5817846226
MESH:D012559 Schizophrenia Clozapine 3.9918806925 17667964 20452607 16141801 20107430 17726453 11763009 20168265 20521326 19369910 18855531 11151749 17123785 20580759 20521320
MESH:D012559 Schizophrenia Haloperidol 3.9918513383 1830565 20107430 19369910
MESH:D012878 Skin Neoplasms Doxorubicin 8.9015692506
MESH:D012878 Skin Neoplasms sodium arsenite 8.9019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3616767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7316709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.0715862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6412854658
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.7918456281
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 2.7918339527
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.5517634840
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.5120210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.083712494 1399818 6587162 7505956 6582329
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.087505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.0816010429 17909728
MESH:D016171 Torsades de Pointes Dobutamine 5.1419353679
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 7.898074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.8917653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.8916712894 11723127 16452187 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5811813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0214692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.0218645019
MESH:D014652 Vascular Diseases sodium arsenite 4.2117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0117678736 17334414 16364871 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Clozapine 4.2917502770 20521320 16402076 16141801 20564506 20107430
MESH:D015431 Weight Loss Clozapine 4.8717933447
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.3716313111
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04210 Apoptosis
KEGG:04976 Bile secretion
KEGG:04020 Calcium signaling pathway
REACT:152 Cell Cycle, Mitotic
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:05414 Dilated cardiomyopathy
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
KEGG:04340 Hedgehog signaling pathway
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
REACT:1505 Integration of energy metabolism
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
REACT:474 Metabolism of carbohydrates
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04740 Olfactory transduction
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:05020 Prion diseases
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04970 Salivary secretion
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
KEGG:04742 Taste transduction
REACT:15518 Transmembrane transport of small molecules
KEGG:04270 Vascular smooth muscle contraction
KEGG:04962 Vasopressin-regulated water reabsorption
KEGG:05110 Vibrio cholerae infection
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33748
    • Releated gene ID Related gene Name
    PA33748PRKACA
    No data
    Releated drug ID Related drug Name
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    PA448478l-arginine
    PA450635nitric oxide
    PA451578tacrolimus
    PA164749238exenatide
    PA451620teriparatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01919 - Pentanal
    DB01940 - Balanol Analog 2
    DB02155 - Balanol Analog 8
    DB02440 - N-Octane
    DB02482 - Phosphonothreonine Indicators and Reagents
    DB02611 - Balanol Analog 1
    DB03374 - 3,5-Diiodotyrosine
    DB03684 - 2-Methyl-2,4-Pentanediol
    DB04098 - Balanol
    DB04522 - Phosphonoserine
    DB04530 - S,S-(2-Hydroxyethyl)Thiocysteine
    DB04707 - HYDROXYFASUDIL
    DB06959 - (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE
    DB06977 - (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE
    DB07107 - (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
    DB07124 - (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
    DB07204 - (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
    DB07235 - N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
    DB07458 - 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE
    DB07583 - (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
    DB07854 - N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
    DB07855 - (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
    DB07856 - 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
    DB07857 - (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
    DB07858 - (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
    DB07859 - 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
    DB07860 - (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
    DB07876 - (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
    DB07947 - ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
    DB07995 - N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
    DB07996 - 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
    DB07997 - N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
    DB08070 - 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
    DB08073 - (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
    DB08113 - 3-pyridin-4-yl-1H-indazole
    DB08114 - 5-benzyl-1,3-thiazol-2-amine
    DB08148 - 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
    DB08149 - 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
    DB08150 - 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
    DB08162 - 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
    DB08231 - MYRISTIC ACID
    DB08568 - (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE
    DB08569 - 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
    DB08756 - (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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