AutismKB 2.0

Annotation Detail for MFN1


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Basic Information Top
Gene Symbol:MFN1 ( DKFZp762F247,FLJ20693,MGC41806,hfzo1,hfzo2 )
Gene Full Name: mitofusin 1
Band: 3q26.33
Quick LinksEntrez ID:55669; OMIM: 608506; Uniprot ID:MFN1_HUMAN; ENSEMBL ID: ENSG00000171109; HGNC ID: 18262
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MFN1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MFN1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MFN1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MFN1 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of MFN1 mRNAincreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNAaffects cotreatment|increases expression 18313992
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of MFN1 mRNAaffects cotreatment|increases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.189612607
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.903712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.461440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.063581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 17.566135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.567505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.5620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.5612371664
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.5619486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.5619486331
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1511906362 8156756 2524372 18759878 11298694 12868966 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.793621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0818289764 9653073 9022650 6679447 18692083 8291058 11289319 18648102 6482804 7440962 9328219 16192314 1440618
MESH:D004362 Drug Toxicity Lamivudine 9.4715040536
MESH:D004362 Drug Toxicity Zidovudine 9.4715040536
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.583581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5820426865
MESH:D005234 Fatty Liver Cyclosporine 8.9319224547
MESH:D005234 Fatty Liver Zidovudine 8.9318299183
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006402 Hematologic Diseases Zidovudine 5.0212579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006509 Hepatitis B Lamivudine 5.3817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.3812044531 15631357 15309715 16476009 15274664
MESH:D015658 HIV Infections Lamivudine 7.4920032539 11141242 9296927 17530837
MESH:D015658 HIV Infections Zidovudine 7.4920032539 11363243 11698656 11141242 17358032
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4818776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.8016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.806582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.8012371664
MESH:D007680 Kidney Neoplasms Zidovudine 19.8012579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.6920370541
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.431399818 598648 3712494 6587162
MESH:D008175 Lung Neoplasms Zidovudine 2.4818800350
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.2817358032
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.267678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.786482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012206 Rhabdomyolysis Lamivudine 5.939296927
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.091399818 6582329 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.318074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014625 Vaginal Neoplasms Zidovudine 5.1212579204
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
REACT:604 Hemostasis
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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