AutismKB 2.0

Annotation Detail for FRMD4A


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Basic Information Top
Gene Symbol:FRMD4A ( FLJ10210,FRMD4,KIAA1294,bA295P9.4 )
Gene Full Name: FERM domain containing 4A
Band: 10p13
Quick LinksEntrez ID:55691; OMIM: NA; Uniprot ID:FRM4A_HUMAN; ENSEMBL ID: ENSG00000151474; HGNC ID: 25491
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
RR interval (heart rate)
Desease Name
RR interval (heart rate)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FRMD4A mRNAaffects expression 21346803
D004317 Doxorubicin FRMD4A protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FRMD4A mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FRMD4A mRNAaffects cotreatment|increases expression 17942748
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FRMD4A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of FRMD4A mRNAincreases expression 19482888
D011374 Progesterone Progesterone results in decreased expression of FRMD4A mRNAdecreases expression 18070364
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FRMD4A mRNAaffects cotreatment|increases expression 17942748
D019772 Topotecan FRMD4A protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6515322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Doxorubicin 4.5817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5814692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4416835633
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms Doxorubicin 1.9115993339 17369602 16826403 15634643 15692762 17983394 16322301 15567936 15994142 16935488 16264153 18234424 18628466 11325840 19526202 15668708 15939500 17426702 16096432 16115903 15136595 18382427 18695136 16595493
MESH:D001943 Breast Neoplasms Progesterone 1.9116175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8516705839
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8516234567 17876044 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.851701930 17173139 20007298 20935162 6705139
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2716201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.7018627295 16364871 16612575 17519947 16278810 15476868 15792986 16651473 16242529 16269455 16455267 17308081 17924179 16109756 17351982 16731534 15811867 15505089 17974986 17131338 17007740 17329180 16952015 17928571 17382496
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0216243910 17334414
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 16919318 17333356 17681005 15861022 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 16354765 15340226 12621046 15668235
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.6317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6320420201
MESH:D004362 Drug Toxicity Doxorubicin 8.7918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.7911462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 10.1517692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004715 Endometriosis Progesterone 9.8216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.8210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.3111558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6712587719 14766674 16244371 18006777 18674790 17875725 16707910 16244372 17888722 16495754 16144979 16330681 16879835
MESH:D006333 Heart Failure Doxorubicin 3.5017481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 9.6616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6616120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.6517606976 15147373 18501091
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916354765 8697196 16959395 15340226 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Progesterone 5.4115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4112878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Doxorubicin 3.2015699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2116705839
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5012878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 4.7219812893 21047994 15975961 19073162 19482888 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7216984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 10.8117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.8118308698 2563599 17172636 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8112151625
MESH:D008175 Lung Neoplasms Doxorubicin 2.4617418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4619555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.7915458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.7917203775 11408345
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0419429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009401 Nephrosis Doxorubicin 5.1316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009447 Neuroblastoma Doxorubicin 7.7115555623
MESH:D009447 Neuroblastoma Topotecan 7.7115176712
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6912819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010051 Ovarian Neoplasms Progesterone 2.5916525653 17393432
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5115749863 18437689 16868541 16729912 16888761 15897917
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012509 Sarcoma Doxorubicin 4.2515625365 18313854 17710206 15675481 16767912 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5318551238
MESH:D012640 Seizures Phenobarbital 6.5316876388 11442880 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Doxorubicin 6.0715692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9315625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.6815862959 16503802
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.0317909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.031399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4916049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.4917653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817678736 17334414 17638931 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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