AutismKB 2.0

Annotation Detail for IARS2


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Basic Information Top
Gene Symbol:IARS2 ( FLJ10326,ILERS )
Gene Full Name: isoleucyl-tRNA synthetase 2, mitochondrial
Band: 1q41
Quick LinksEntrez ID:55699; OMIM: 612801; Uniprot ID:SYIM_HUMAN; ENSEMBL ID: ENSG00000067704; HGNC ID: 29685
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
TRNA-CHARGING-PWYtRNA charging pathway
Pathway IDPathway Name
hsa00970Aminoacyl-tRNA biosynthesis
hsa00290Valine, leucine and isoleucine biosynthesis
Pathway IDPathway Name
Gene Expression
No data
No data
Pathway IDPathway Name
500661Mitochondrial tRNA aminoacylation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D017313 Fenretinide Fenretinide affects the expression of IARS2 mRNAaffects expression 16570282
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IARS2 mRNAincreases expression 19465110
D014303 Trinitrotoluene Trinitrotoluene affects the expression of IARS2 mRNAaffects expression 21346803
D014501 Uranium Uranium affects the expression of IARS2 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of IARS2 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.4314514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 10.437525203
MESH:D000230 Adenocarcinoma Fenretinide 3.1710697514
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001932 Brain Neoplasms Fenretinide 4.7016187019
MESH:D001943 Breast Neoplasms Fenretinide 2.2816601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 2.8016270382 17159502
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.2516274795
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 16120746 18850075
MESH:D002386 Cataract Trinitrotoluene 4.0515817613 14694615
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 6.0216154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215668235 8697196 16354765 15340226 12621046
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6917273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.3817141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 10.3815095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003490 Cyanosis Trinitrotoluene 5.4118551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.3120420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 4.3121346803 18551238
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5118230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.4320067830
MESH:D005909 Glioblastoma Fenretinide 4.1016187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.3815340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 10.3815817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6618606429 16354765 15340226 16959395 8697196
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118670907 18850075
MESH:D007248 Infertility, Male Trinitrotoluene 3.9012150543
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007972 Leukoplakia, Oral Fenretinide 6.6616707609
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.7810697514
MESH:D008545 Melanoma Fenretinide 2.8616270382
MESH:D009062 Mouth Neoplasms Fenretinide 4.5916274795
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009336 Necrosis Trinitrotoluene 5.3018551238
MESH:D009369 Neoplasms Fenretinide 3.4417353921 15958647
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 6.2216303764
MESH:D009784 Occupational Diseases Trinitrotoluene 4.6814694615 17852074 12819281
MESH:D010051 Ovarian Neoplasms Fenretinide 3.3116133793
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.4515580305
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Fenretinide 4.0417024972
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012162 Retinal Degeneration Fenretinide 4.6616303925
MESH:D012640 Seizures Trinitrotoluene 3.6718551238
MESH:D012878 Skin Neoplasms Fenretinide 6.3616467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.3616192470
MESH:D013163 Splenomegaly Trinitrotoluene 5.6915817613
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 3.4116720286
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.9116154183
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:00970 Aminoacyl-tRNA biosynthesis
REACT:71 Gene Expression
KEGG:00290 Valine, leucine and isoleucine biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671670
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA10090l-glutamine
    PA449882l-histidine
    PA450197l-leucine
    PA450280l-lysine
    PA450423l-methionine
    PA450931l-phenylalanine
    PA451330l-serine
    PA451673l-threonine
    PA10323l-tryptophan
    PA451822l-tyrosine
    PA451843l-valine
    PA449173l-cysteine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00167 - L-Isoleucine Dietary supplement;Micronutrient;Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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