AutismKB 2.0

Annotation Detail for NECAP2


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Basic Information Top
Gene Symbol:NECAP2 ( FLJ10420 )
Gene Full Name: NECAP endocytosis associated 2
Band: 1p36.13
Quick LinksEntrez ID:55707; OMIM: 611624; Uniprot ID:NECP2_HUMAN; ENSEMBL ID: ENSG00000157191; HGNC ID: 25528
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NECAP2 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NECAP2 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NECAP2 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of NECAP2 mRNAincreases expression 20106945
D007657 Ketone Bodies Ketone Bodies results in decreased expression of NECAP2 mRNAdecreases expression 16807920
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NECAP2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NECAP2 mRNAaffects binding|increases activity|increases expression 19710929
C059514 resveratrol resveratrol results in increased expression of NECAP2 mRNAincreases expression 19371625
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 4.1316538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000236 Adenoma resveratrol 3.4615688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000544 Alzheimer Disease resveratrol 2.6216162502 16183991
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001169 Arthritis, Experimental resveratrol 3.6617115116
MESH:D050197 Atherosclerosis resveratrol 3.4217967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D002545 Brain Ischemia resveratrol 4.6817600658
MESH:D001943 Breast Neoplasms resveratrol 2.6717651959 16393696 17534123
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.133084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 3.1319321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9916675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7816227395
MESH:D002318 Cardiovascular Diseases resveratrol 3.6515458977
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1712371664
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D003092 Colitis resveratrol 4.4916474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D003327 Coronary Disease resveratrol 3.9216507316
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.0016873680
MESH:D003928 Diabetic Nephropathies resveratrol 4.2116286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6512958197 16177239 16393943 15968718 12392966 16109766 11529661 19085960 16485898 19416960 19370779 16227642 19164858 10915739 11739529 17906064 17522070 18713872 14550746 11287661 2444490 12705907 10663392 14986274 19420014 19739265 12594235 11834606 11421492 16081117 12540782 11461765 11743745 16781746 10774834 14725611 15619225 18071297 17562736 12153990 19923254
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 7.8512083418
MESH:D004487 Edema resveratrol 7.858985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3517872969
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.2117923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Cyclosporine 8.5119224547
MESH:D005234 Fatty Liver pirinixic acid 8.5119236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3519176532 19772884 16221962 18467677
MESH:D006561 Herpes Simplex resveratrol 4.5716876885
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia resveratrol 4.2917188708
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006949 Hyperlipidemias resveratrol 4.3316873680
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5717488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.0117600658
MESH:D007249 Inflammation resveratrol 2.9716366677
MESH:D007251 Influenza, Human resveratrol 4.9916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.2818776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7516087638
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6816611625 19784758 19014921 11587558 19460945 16610002 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 4.9020007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 4.9019812893 19073162 19321006 20405173
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3817365036
MESH:D016393 Lymphoma, B-Cell resveratrol 4.6017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.1014749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.6415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.278985016 11606380
MESH:D008545 Melanoma resveratrol 2.4017992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2716166281 18303189 16966607
MESH:D008659 Metabolic Diseases resveratrol 4.6617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009101 Multiple Myeloma resveratrol 3.6617935668 16490592 16267019 14749477 17164350 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 6.0719151258
MESH:D009203 Myocardial Infarction resveratrol 6.0716525036 17125593 17188708 16317513 17015251 16456233
MESH:D017202 Myocardial Ischemia resveratrol 4.2317125593 17015251
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009205 Myocarditis resveratrol 5.1617322642
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.368985016
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.1418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 9.1417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.7017929310
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5617513867
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.5716679765
MESH:D011471 Prostatic Neoplasms resveratrol 3.5915767336 17636462 16731767 17675339 17718901 17804756
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1117365031 17322281 17975199 15814490
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.0316325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.9719058328
MESH:D015427 Reperfusion Injury resveratrol 6.9717520802 16314181 15827377 16317513 17058453
MESH:D012878 Skin Neoplasms resveratrol 3.1415837718 8985016
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7516321402
MESH:D014062 Tongue Neoplasms resveratrol 4.4816227395
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3717473185
MESH:D014594 Uterine Neoplasms resveratrol 4.4617044934
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6617488730
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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