AutismKB 2.0

Annotation Detail for POLR3E


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Basic Information Top
Gene Symbol:POLR3E ( RPC5,SIN )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Band: 16p12.2
Quick LinksEntrez ID:55718; OMIM: NA; Uniprot ID:RPC5_HUMAN; ENSEMBL ID: ENSG00000058600; HGNC ID: 30347
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of POLR3E mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of POLR3E mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of POLR3E mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of POLR3E mRNAdecreases expression 19150397
C099555 CD 437 CD 437 results in increased expression of POLR3E proteinincreases expression 15059897
C014347 decitabine decitabine results in decreased expression of POLR3E mRNAdecreases expression 19194470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms decitabine 2.5418320071 19208741
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6619215824
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6219164858 12958197 2444490 12153990 12594235 17522070 19370779 10915739 16393943 16177239 15968718 16781746 19923254 14725611 12392966 16109766 11739529 17906064 19420014 11529661 17562736 12705907 12540782 16227642 15619225 19739265 10774834 10663392 16485898 11834606 18713872 19085960 11743745 14550746 11287661 14986274 16081117 19416960 18071297 11461765 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006258 Head and Neck Neoplasms decitabine 3.6919215824
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D007938 Leukemia decitabine 3.2118980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.3319117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4218206229 18460780 18704418 19010910 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16610002 12969438 16611625 19014921 11587558 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.247678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.726135515 2876786 2876784
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008545 Melanoma decitabine 2.2816505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009101 Multiple Myeloma decitabine 3.5618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5419010910 19157545 16882708 18608210
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D009369 Neoplasms decitabine 2.8419116145 17925555 19470736
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010051 Ovarian Neoplasms CD 437 5.5917474084
MESH:D010051 Ovarian Neoplasms decitabine 5.5919259094 19331143
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8519294695
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 3.5717967635
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.8616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.8616049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 12.8616720286
MESH:D001749 Urinary Bladder Neoplasms decitabine 12.8617616700 19087683
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
Pathway ID Pathway Name
KEGG:04623 Cytosolic DNA-sensing pathway
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
KEGG:03020 RNA polymerase
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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