AutismKB 2.0

Annotation Detail for VPS35


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Basic Information Top
Gene Symbol:VPS35 ( DKFZp434E1211,DKFZp434P1672,FLJ10752,FLJ13588,FLJ20388,MEM3 )
Gene Full Name: vacuolar protein sorting 35 homolog (S. cerevisiae)
Band: 16q11.2
Quick LinksEntrez ID:55737; OMIM: 601501; Uniprot ID:VPS35_HUMAN; ENSEMBL ID: ENSG00000069329; HGNC ID: 13487
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of VPS35 mRNAdecreases expression 19933214
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VPS35 mRNAdecreases expression 20018196
D005472 Fluorouracil Fluorouracil affects the expression of VPS35 mRNAaffects expression 16584549
C056933 fumonisin B1 fumonisin B1 results in increased expression of VPS35 mRNAincreases expression 16221962
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of VPS35 mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of VPS35 mRNA]affects expression|affects reaction 16166738
C006253 pirinixic acid pirinixic acid results in increased expression of VPS35 mRNAincreases expression 16221962
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Nickel 10.4416166738
MESH:D055371 Acute Lung Injury pirinixic acid 10.4418653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000740 Anemia Fluorouracil 4.0217963324 16511603 15504547
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.6119217205 16110121 18357371 18608205 16595493 16557594 15136595
MESH:D001943 Breast Neoplasms Nickel 2.6115986119
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1117088986 18930000 17971768 17045692 16799960 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5616757204 18986760 16280240 17066447
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717725105 17287894 18772588 17018589 17169374 15001691 17016597 16340194 16510598 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016303861 18448328 18509181 17594712 18383874 14970324 17401013 18288408 15148649 18949393 17454858 16391804 15289873 17255274 16524972 16331619 17016601 18802399 17695437 17094418 16282729 20501625
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D017449 Dermatitis, Allergic Contact Nickel 4.3619470301 17100760 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact Nickel 4.992952479
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 2.9816221962
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7316337965 15173087 16785472 16481741 17638652
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915102660 18337622 15162350
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly fumonisin B1 10.1916221962
MESH:D006529 Hepatomegaly pirinixic acid 10.1919176532 18467677 16221962 19772884
MESH:D015658 HIV Infections Nickel 3.9617263646
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007249 Inflammation Nickel 3.5616166738
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Fluorouracil 4.8615113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms pirinixic acid 4.8620007298 15890375 16377806
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms Fluorouracil 5.4416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7515113037 16500647 16929163 19003803
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3018286688 16160472 15538739 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0016424979 19084572 17522103 17498489 18396642 19015929 17172411 18567086 16951190 15786421
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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