AutismKB 2.0

Annotation Detail for ARFGAP1


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Basic Information Top
Gene Symbol:ARFGAP1 ( ARF1GAP,HRIHFB2281,MGC39924 )
Gene Full Name: ADP-ribosylation factor GTPase activating protein 1
Band: 20q13.33
Quick LinksEntrez ID:55738; OMIM: 608377; Uniprot ID:ARFG1_HUMAN; ENSEMBL ID: ENSG00000101199; HGNC ID: 15852
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
Pathway IDPathway Name
Diabetes pathways
Membrane Trafficking
Pathway IDPathway Name
200167Arf1 pathway
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500011COPI Mediated Transport
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ARFGAP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ARFGAP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARFGAP1 mRNAaffects expression 16483693
D005472 Fluorouracil Fluorouracil results in increased expression of ARFGAP1 proteinincreases expression 15331170
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARFGAP1 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4917638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000740 Anemia Fluorouracil 4.0616511603 17963324 15504547
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4416110121 16595493 18357371 18608205 19217205 16557594 15136595
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 3.8517121937
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.803084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8017971768 16332177 16799960 18930000 17045692 17088986
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5718986760 16757204 17066447 16280240
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.006135515
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817725105 16510598 18772588 15001691 17172411 17018589 17287894 16340194 17016597 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0016391804 16524972 18448328 17695437 17094418 18802399 15289873 18509181 17594712 20501625 18288408 18383874 18949393 16282729 17255274 16303861 17016601 14970324 15148649 17401013 16331619 17454858
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D002658 Developmental Disabilities marker/mechanism 20805988
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9911739529 16177239 14725611 11421492 12153990 17522070 10663392 15968718 12705907 19085960 16781746 17906064 18071297 11287661 11461765 19739265 11743745 10915739 10774834 16485898 19416960 17562736 14550746 12392966 12540782 16081117 18713872 19420014 11529661 12958197 11834606 19923254 16393943 16109766 2444490 12594235 16227642 15619225 19164858 19370779 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216337965 16785472 15173087 16481741 17638652
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6118337622 15102660 15162350
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4819772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.5116705839
MESH:D007680 Kidney Neoplasms Fluorouracil 8.5116985049
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 19784758 12969438 12587719 16610002 19460945 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 8.087678174
MESH:D008113 Liver Neoplasms Fluorouracil 8.0817045692 15113037 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 8.0815890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.742876786 6135515 2876784
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9016757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009369 Neoplasms Fluorouracil 5.4916928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 5.4917405874
MESH:D009422 Nervous System Diseases marker/mechanism 20805988
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7615113037 16929163 19003803 16500647
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3415538739 18722050 18286688 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7618551238
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0018567086 19084572 17522103 16951190 18396642 15786421 16424979 17172411 17498489 19015929
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3416280240
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2316803524
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
KEGG:04144 Endocytosis
REACT:11123 Membrane Trafficking
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164741246
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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