AutismKB 2.0

Annotation Detail for ENAH


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Basic Information Top
Gene Symbol:ENAH ( ENA,MENA,NDPP1 )
Gene Full Name: enabled homolog (Drosophila)
Band: 1q42.12
Quick LinksEntrez ID:55740; OMIM: 609061; Uniprot ID:ENAH_HUMAN; ENSEMBL ID: ENSG00000154380; HGNC ID: 18271
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Axon guidance
Signaling in Immune system
Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
200105E-cadherin signaling in the nascent adherens junction
200057CDC42 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ENAH mRNAdecreases expression 18648102
D006710 Homocysteine Homocysteine results in decreased expression of ENAH mRNAdecreases expression 17326132
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ENAH mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ENAH mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ENAH mRNAincreases expression 17484886
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENAH mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil ENAH protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
C406082 monomethylarsonous acid monomethylarsonous acid results in increased expression of ENAH mRNAincreases expression 20024957
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENAH mRNAaffects cotreatment|increases expression 17942748
D002762 Cholecalciferol Cholecalciferol results in increased expression of ENAH mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2714692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.2717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Fluorouracil 9.2315504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.2311748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Homocysteine 3.0316297937 20468076
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.2416142846
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8320146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.8319217205 18608205 15136595 18357371 16595493 16110121 16557594
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916011737 3786805 16124888 16227642 18705752 10355542 16192424 15673190 16050911 15700767 16097048 15721981
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 8.6517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.743581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7418788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.7416332177 17088986 17045692 16799960 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.747296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.7418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7916280240 18986760 16757204 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.007505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0020889678
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 12.0019716837
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2819486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2815861022 17681005 17110522 11677210 17333356 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1616354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2617287894 18772588 17172411 15001691 17016597 16340194 17018589 17169374 16510598 17725105
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015148649 20501625 16282729 14970324 17695437 16524972 16331619 18949393 18802399 17094418 18509181 16391804 17594712 18448328 15289873 18288408 17454858 17255274 17016601 16303861 17401013 18383874
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D003324 Coronary Artery Disease Homocysteine 3.8116379339
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0112868966 11298694 18759878 8970840 8156756 11906362 2524372 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.4418289764 9022650 18648102 9328219 9653073 16192314 11289319 7440962 18692083 6679447 8291058 1440618 6482804
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.4415027814 16177239 11566570 2869522 10092053 15968718 7120509 17522070 6623471 21278145 6884620 10915739 15998439 19085960 7179309 16227642 3786805 3732212 19336974 9327722 7440962 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.723581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.7216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.7216337965 16481741 15173087 17638652 16785472
MESH:D017889 Exfoliation Syndrome Homocysteine 5.9416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.2712795759 12631006 15959796 17595544 19224547 61145 16239168 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005901 Glaucoma Homocysteine 5.4716504073
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.7220471113
MESH:D006330 Heart Defects, Congenital Homocysteine 11.7219638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.7211294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.896705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.8919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 16959395 15340226 16354765 8697196
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8617369066 18234410 17292331
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.966582329
MESH:D007680 Kidney Neoplasms Fluorouracil 7.9616985049
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917334410 11408273 17174718 16943688 11903743 16239168 21278145 17157831 16221502
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3318279442 17557913 18166357 18251166 18187930 15338365 18156304 18412020 12445421 17805973 12958196 18395914 17976157 18376398 17944888 15931870 15362042 17714472 12586293 18210741 15996030 16248980 15876570 17823541 18395095 12666154 16097048 18277467 18705752 15673190 18339082 14748882 18429990 14716496 16116963 12546737 16033810 15730626 17631135 18472332 12632512 12898905 17708605 12632514 14716833 16638106 15818738 17922224 10355542 16015684 16192424 16136751 17525996 11481614 16011737 14620537 15052691 17869086 18418968 15925388 17565644 17481882 17721639 12389079 12609069 18054572 12741479 18006644 17766677 12649538 16027843 15893842 17640975 15650968 18205269 14724832 17900296 12445418 18317297 18472094 15123356 20821823 18420326 15370692 13678700 17698563 15057751 14512876 18263696 15959796 12667390 18481824 17761835
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1216246199 16964402 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8516899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.1819294768
MESH:D008113 Liver Neoplasms Fluorouracil 11.1816603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.38598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4720464547 18569708 20064080 18816296 17053015 20869020 18520028 20135361 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 3.4715246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008591 Meningomyelocele Homocysteine 5.7516602021
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.9716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.9716757204 18986760
MESH:D009203 Myocardial Infarction Homocysteine 3.7817412321
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3211141357
MESH:D009369 Neoplasms Fluorouracil 5.3218600527 18239605 16928823
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.586482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7216929163 16500647 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010300 Parkinson Disease Homocysteine 3.6316275827
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6617292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6617024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6618626508 19082440
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1616160472 18722050 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012559 Schizophrenia Homocysteine 3.1216641680
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4117431481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4617522103 16951190 15786421 18567086 19084572 17498489 18396642 17172411 16424979 19015929
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016582329 3712494 7505956 1399818 6587162
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.778074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7717053015
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 8.7720375083
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04810 Regulation of actin cytoskeleton
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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