AutismKB 2.0

Annotation Detail for CNDP2


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Basic Information Top
Gene Symbol:CNDP2 ( CN2,CPGL,FLJ10830,HsT2298,PEPA )
Gene Full Name: CNDP dipeptidase 2 (metallopeptidase M20 family)
Band: 18q22.3
Quick LinksEntrez ID:55748; OMIM: 169800; Uniprot ID:CNDP2_HUMAN; ENSEMBL ID: ENSG00000133313; HGNC ID: 24437
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CNDP2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CNDP2 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of CNDP2 mRNAincreases expression 15003993
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of CNDP2 mRNAincreases expression 17490981
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CNDP2 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of CNDP2 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CNDP2 mRNAincreases expression 17557909
D019833 Genistein Genistein results in increased expression of CNDP2 mRNAincreases expression 15289156
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CNDP2 protein]affects binding|increases reaction 17220478
D015741 Metribolone Metribolone results in increased expression of CNDP2 proteinincreases expression 17152098
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of CNDP2 mRNAincreases expression 17560707
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CNDP2 mRNAincreases expression 17560707
C037219 quinoline quinoline analog results in increased expression of CNDP2 proteinincreases expression 18645022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CNDP2 mRNAincreases expression 18691609
D014303 Trinitrotoluene Trinitrotoluene affects the expression of CNDP2 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.857525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Estradiol 7.1511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1514692618
MESH:D000230 Adenocarcinoma Genistein 7.1511473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9715324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9717261762 12948864 14630087 17289903 16675129 18497071 17018787 19861407
MESH:D001943 Breast Neoplasms Genistein 1.9717200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.5216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.523084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.5216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.5216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.5216924424
MESH:D006528 Carcinoma, Hepatocellular quinoline 11.52598648
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.3416332659
MESH:D002386 Cataract Acetaminophen 7.6110977129
MESH:D002386 Cataract Trinitrotoluene 7.6114694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.796135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7918566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9111677210 16919318 17110522 16105132 17333356 17681005 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 12621046 8697196 15668235 15340226
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.4417141729 14669216
MESH:D000013 Congenital Abnormalities Trinitrotoluene 9.4415095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6216002989 12952375
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4718551238
MESH:D003490 Cyanosis Trinitrotoluene 11.4718551238
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3716647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.1118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1114725611 18071297 16781746 19085960 19416960 15968718 11739529 12705907 11461765 16081117 11743745 10915739 18713872 16109766 12153990 17906064 16393943 14986274 12594235 19739265 19164858 16177239 11834606 11287661 10663392 19923254 19420014 17562736 10774834 11421492 11529661 17522070 12540782 12958197 19370779 15619225 2444490 16485898 12392966 14550746 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1120420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.1121346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema perfluorooctanoic acid 7.1212083418 17259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.1716402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.1716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.7215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 12.7218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 12.7211473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8715345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6916513791 16611131 16002989 16534752 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0316452187
MESH:D005909 Glioblastoma Genistein 7.7916598420
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 7.7917162496
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006390 Hemangioendothelioma quinoline 6.00598648
MESH:D006394 Hemangiosarcoma quinoline 5.05598648
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 15.073609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0715340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 15.0715817613
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.0012083418
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5112960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 11.4916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.4916945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.4215036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0117937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.0112150543
MESH:D007249 Inflammation perfluorooctanoic acid 5.2312083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2312200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0016393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 5.9812587719 15629191
MESH:D007674 Kidney Diseases Estradiol 5.9815618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.7316705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.7316762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 12.7315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1317184923
MESH:D007938 Leukemia Genistein 3.0517468513 18980019
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.318812269
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5117823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6412969438 11587558 19784758 16611625 12587719 19014921 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.907678174
MESH:D008113 Liver Neoplasms Diethylstilbestrol 10.9016712894 15890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 10.9018709148 14757943
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.846135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6116002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2011408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.2012929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D009203 Myocardial Infarction Genistein 2.8817141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.6517141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.9618551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 10.9618551238
MESH:D009362 Neoplasm Metastasis quinoline 4.06598648
MESH:D009369 Neoplasms Diethylstilbestrol 2.7915313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 24.0311399458
MESH:D009421 Nervous System Malformations Estradiol 24.0311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 24.0316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.0314600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.029802331
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3916049721
MESH:D009784 Occupational Diseases Trinitrotoluene 9.3914694615 17852074 12819281
MESH:D010024 Osteoporosis Genistein 3.2819401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1416169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9519005980
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.2714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7415687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.8517184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 16.8517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.8511222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6217136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.6216740699
MESH:D011471 Prostatic Neoplasms Genistein 2.6215256057 15378649 16925846
MESH:D011537 Pruritus Ethinyl Estradiol 3.3915861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Trinitrotoluene 6.3218551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.678532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.0416002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0416709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.2715817613
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2616049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.2616712894 17306315 16452187
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.0816175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.2714652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.6915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.6914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5116002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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