AutismKB 2.0

Annotation Detail for PRKAR1B


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Basic Information Top
Gene Symbol:PRKAR1B ( PRKAR1 )
Gene Full Name: protein kinase, cAMP-dependent, regulatory, type I, beta
Band: 7p22.3
Quick LinksEntrez ID:5575; OMIM: 176911; Uniprot ID:KAP1_HUMAN; ENSEMBL ID: ENSG00000188191; HGNC ID: 9390
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04210Apoptosis
Pathway IDPathway Name
Diabetes pathways
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P00025Hedgehog signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P05731GABA-B receptor II signaling
P00055Transcription regulation by bZIP transcription factor
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PRKAR1B mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRKAR1B mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PRKAR1B mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRKAR1B mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKAR1B mRNAaffects cotreatment|increases expression 17942748
D011374 Progesterone Progesterone affects the expression of PRKAR1B mRNAaffects expression 17251523
C017947 sodium arsenite sodium arsenite results in increased expression of PRKAR1B mRNAincreases expression 16322246
D013629 Tamoxifen Tamoxifen affects the expression of PRKAR1B mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKAR1B mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3516712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 4.6215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Progesterone 1.8517614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tamoxifen 1.8517242785 19066611 18629630 16818667 16202921 17049068 19142967 19244106 19189212 19487384 15565566 18815881 19115204 17440819 18855134 21152245 18984771 18821012 11161223 18997820 20544844 19221464 15668708 19288272 20135344 17261762 18351453 19189210 19155303 16273361 19289846 20065188 20005174 20859285 18425577 19059307 19410462 19103187 17893378 19084267 21138602 19011961 19200415 20390343 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416050911 16124888 15721981 16011737 15700767 18705752 3786805 10355542 16192424 16227642 16097048 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.863084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8618788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8616507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8616924424
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4418572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1719524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0711677210 15861022 16105132 17110522 17333356 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 16354765 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5319416960 14550746 19420014 18713872 16177239 10915739 17522070 19370779 14986274 11743745 16781746 11739529 11421492 17562736 12705907 12153990 16227642 12594235 10774834 10663392 19085960 11529661 11461765 19164858 12958197 12540782 11834606 19923254 15968718 2444490 14725611 16393943 16109766 19739265 18071297 17906064 16081117 16485898 12392966 11287661 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5315027814 16177239 7120509 21278145 7179309 15968718 3786805 7440962 16227642 10915739 4309450 10092053 11566570 19085960 17522070 2869522 6623471 19336974 3732212 9327722 15998439 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.3312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.3317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.3319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Progesterone 9.8216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.829294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.8012795759 16045604 12631006 17595544 61145 16239168 19224547 15959796
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8015345470
MESH:D005234 Fatty Liver Tamoxifen 14.8019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.8220067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2317937319
MESH:D007248 Infertility, Male sodium arsenite 7.2312646999 15346721
MESH:D007249 Inflammation Progesterone 9.0615869954
MESH:D007249 Inflammation Tamoxifen 9.0619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.4515629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.4520008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9416221502 16943688 21278145 17157831 11903743 11408273 16239168 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5818156304 18395914 18054572 18277467 15925388 16192424 16638106 12586293 12445421 12546737 16033810 15730626 12445418 12666154 16116963 17766677 18263696 17823541 12609069 12649538 16027843 15673190 17565644 12741479 18472094 15123356 18166357 17481882 14620537 17714472 18205269 12958196 12667390 12632514 17900296 17761835 15893842 18251166 14724832 17557913 15057751 17708605 18317297 17869086 13678700 17631135 15931870 18376398 15876570 16136751 18420326 14748882 16011737 14716496 17640975 15818738 15650968 12632512 18187930 15338365 16097048 18412020 18279442 17805973 17525996 18210741 15959796 15996030 15362042 16248980 17721639 16015684 11481614 18472332 18481824 12898905 18418968 18395095 17698563 14512876 17944888 14716833 18705752 10355542 17922224 18429990 15370692 17976157 20821823 18006644 15052691 12389079 18339082
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5812878042
MESH:D008107 Liver Diseases Acetaminophen 4.0916611625 19014921 12587719 12969438 16610002 19460945 19784758 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0916964402 15720792 15830285 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.4519294768
MESH:D008113 Liver Neoplasms sodium arsenite 11.4515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 11.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3012151625
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms sodium arsenite 3.5317077188 17306315 19931552 16712894 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 3.5318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5319555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.6417203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6414580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma sodium arsenite 3.4416487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.4419393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms sodium arsenite 2.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Progesterone 5.1917393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1917306315 15276417
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012878 Skin Neoplasms sodium arsenite 5.9719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.2315862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.2319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.4216452187 11723127 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.4217572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:04210 Apoptosis
REACT:15380 Diabetes pathways
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
REACT:1505 Integration of energy metabolism
REACT:15295 Opioid Signalling
REACT:11061 Signalling by NGF
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33756
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA449396dopamine
    PA449773glucose
    PA164743471adenosine triphosphate
    PA448334alprostadil
    PA449470epinephrine
    PA164744376adenosine monophosphate
    PA451123progesterone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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