AutismKB 2.0

Annotation Detail for UGGT2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UGGT2 ( FLJ10873,FLJ11485,HUGT2,MGC117360,MGC150689,MGC87276,UGCGL2,UGT2 )
Gene Full Name: UDP-glucose glycoprotein glucosyltransferase 2
Band: 13q32.1
Quick LinksEntrez ID:55757; OMIM: 605898; Uniprot ID:UGGG2_HUMAN; ENSEMBL ID: ENSG00000102595; HGNC ID: 15664
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of UGGT2 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of UGGT2 mRNAincreases expression 20106945
C056507 gemcitabine gemcitabine results in increased expression of UGGT2 mRNAincreases expression 17039268
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of UGGT2 mRNAaffects cotreatment|increases expression 17183730
C051890 irinotecan irinotecan analog results in decreased expression of UGGT2 mRNAdecreases expression 18927307
D013467 Sulindac Sulindac results in increased expression of UGGT2 mRNAincreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UGGT2 mRNAdecreases expression 18495758
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of UGGT2 mRNAaffects cotreatment|increases expression 17183730
D014635 Valproic Acid Valproic Acid results in increased expression of UGGT2 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in decreased expression of UGGT2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.8214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2815322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1319490988
MESH:D058186 Acute Kidney Injury Sulindac 4.527897758
MESH:D000230 Adenocarcinoma Sulindac 3.1511910360
MESH:D000236 Adenoma Sulindac 3.8910223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.7919003578 15623613 11535846 11874996 12394442 17611924 16460482
MESH:D000550 Amblyopia Valproic Acid 5.5517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7417497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 17157402 18940202 18316065 20603192 17507914 18985861 15238991 18558336 19460635 18396377 19232924 16609825 18177632 17688650
MESH:D001714 Bipolar Disorder Valproic Acid 3.1720046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.438888407
MESH:D001913 Bowen's Disease Sulindac 5.6711207687
MESH:D001943 Breast Neoplasms gemcitabine 2.1018382427 17039268
MESH:D001943 Breast Neoplasms Sulindac 2.1016642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.8116097048 16124888 10355542 16050911 15700767 15673190 16227642 3786805 16011737 18705752 15721981 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.8116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8518788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 16354765 12621046 15668235 8697196
MESH:D003110 Colonic Neoplasms irinotecan 4.3217725105 17287894
MESH:D003110 Colonic Neoplasms Sulindac 4.3212902858 12458338
MESH:D015179 Colorectal Neoplasms irinotecan 3.0215273666 16391804 17454858 18259882 16303861 17159606 18509181
MESH:D015179 Colorectal Neoplasms Sulindac 3.0210666051 11076880 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8815322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.888888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8819769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.4212861449 17621415
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.5116177239 2869522 10092053 10915739 7440962 21278145 15968718 7179309 17522070 9327722 6623471 3786805 11566570 16227642 15027814 4309450 19336974 3732212 7120509 19085960 15998439 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.511733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Valproic Acid 4.271851702
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004715 Endometriosis Sulindac 9.8415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.849294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.413659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.233922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.776426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.353659116
MESH:D004938 Esophageal Neoplasms Sulindac 3.1812235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.3516045604 16239168 12631006 17595544 12795759 19224547 15959796 61145
MESH:D005234 Fatty Liver Cyclosporine 14.3519224547
MESH:D005234 Fatty Liver Valproic Acid 14.3514986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3718558336 8888407
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.7614745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.4219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 16.2918705752
MESH:D005355 Fibrosis Cyclosporine 16.2912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.2920067830
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2511910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9016080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616959395 15340226 8697196 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8816612254
MESH:D007249 Inflammation Sulindac 5.563291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5612878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007414 Intestinal Neoplasms Sulindac 4.8312628509 12351151 10213222 10223192 12584176 12663524
MESH:D007417 Intestinal Polyps Sulindac 5.2112394442 11245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.388314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.3812488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9111903743 17334410 16943688 17174718 16221502 11408273 16239168 17157831 21278145
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3412468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5717823541 18339082 15893842 12445421 17976157 15673190 18166357 17805973 14748882 15123356 17944888 15996030 18317297 18251166 18420326 18210741 16116963 16248980 14724832 17481882 16015684 18429990 16033810 15931870 17565644 17525996 12609069 17708605 11481614 15362042 12666154 15876570 15650968 18054572 20821823 18395914 16097048 18156304 16011737 15370692 15959796 14512876 14716496 18418968 14716833 17766677 15057751 12632512 18395095 18187930 18277467 17631135 18481824 12586293 18705752 17721639 17900296 18376398 18263696 10355542 18472332 16638106 12389079 17922224 16136751 18205269 12445418 17698563 15052691 18472094 18412020 18279442 17557913 17761835 12632514 12898905 16192424 15925388 12667390 13678700 14620537 16027843 12649538 12741479 15818738 17640975 18006644 12546737 15730626 15338365 12958196 17714472 17869086
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5716169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5616246199 15720792 16964402 17285989 15830285
MESH:D008107 Liver Diseases Sulindac 4.5616867024 14986274
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5817228818
MESH:D008175 Lung Neoplasms Sulindac 3.6219359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6211884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.6211062179
MESH:D008545 Melanoma Sulindac 2.8516642371
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3318765137 18803445
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.238888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2516359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D019636 Neurodegenerative Diseases Sulindac 4.4417266991 16850258
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D010146 Pain Sulindac 3.963291741
MESH:D010190 Pancreatic Neoplasms gemcitabine 6.2018383843 11504793 18992248 17440100 16929163
MESH:D010190 Pancreatic Neoplasms Sulindac 6.2011504793 16820089
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4311118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.4320603192
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.8612752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8714763951 11044598 16876388 17978042 15475178 3137016 11738929 1511512
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9419490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8612833885
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.5517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.813119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.908888407
MESH:D014594 Uterine Neoplasms Sulindac 4.8418645019
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
REACT:17015 Metabolism of proteins
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved