AutismKB 2.0

Annotation Detail for TTC17


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Basic Information Top
Gene Symbol:TTC17 ( DKFZp686D20222,FLJ10890,FLJ13099,FLJ23673 )
Gene Full Name: tetratricopeptide repeat domain 17
Band: 11p12-p11.2
Quick LinksEntrez ID:55761; OMIM: NA; Uniprot ID:TTC17_HUMAN; ENSEMBL ID: ENSG00000052841; HGNC ID: 25596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TTC17 mRNAaffects expression 21346803
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of TTC17 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TTC17 mRNAaffects expression 17555576
D012643 Selenium Selenium results in decreased expression of TTC17 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of TTC17 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TTC17 mRNAincreases expression 18796159
D014810 Vitamin E Vitamin E results in decreased expression of TTC17 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7917474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 1.7918629630 18425577 19155303 19288272 19142967 17440819 16202921 20005174 20135344 17049068 11161223 19200415 16273361 19066611 19244106 19487384 19103187 21152245 18351453 20544844 19059307 17261762 18855134 19011961 15565566 19189210 18821012 18997820 18984771 20390343 19221464 19084267 21138602 15668708 17893378 20859285 17242785 19410462 16873071 19189212 19289846 16818667 18815881 19115204 20065188
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0916705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717681005 17333356 16105132 16919318 17110522 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5520055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2120544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.8620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.8610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.8616080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 16354765 8697196 18606429 15340226
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212878042 12200463
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Vitamin E 2.9512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1716705839
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1718625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.6016169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.437678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4321137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 11.4316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.272876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2712151625
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0420464547 18569708 17053015 18816296 20869020 6695378 18520028 20135361 20064080
MESH:D008175 Lung Neoplasms Tamoxifen 5.0418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.0411062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6019196723 19196722 11731420 16827153 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.267678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.4815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8217053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.828653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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