AutismKB 2.0

Annotation Detail for PRKAR2B


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Basic Information Top
Gene Symbol:PRKAR2B ( PRKAR2,RII-BETA )
Gene Full Name: protein kinase, cAMP-dependent, regulatory, type II, beta
Band: 7q22.3
Quick LinksEntrez ID:5577; OMIM: 176912; Uniprot ID:KAP3_HUMAN; ENSEMBL ID: ENSG00000005249; HGNC ID: 9392
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04210Apoptosis
Pathway IDPathway Name
Cell Cycle, Mitotic
Diabetes pathways
Signalling by NGF
Transmembrane transport of small molecules
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04377Beta1 adrenergic receptor signaling pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019Endothelin signaling pathway
P04386Histamine H2 receptor mediated signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P00025Hedgehog signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
P00055Transcription regulation by bZIP transcription factor
Pathway IDPathway Name
500383Loss of proteins required for interphase microtubule organization from the centrosome
500384Loss of Nlp from mitotic centrosomes
Related Diseases/Disorders Top
No data
No data
Desease Name
PHARMACOGENOMIC
response to antipsychotic treatment
Desease Name
Response to antipsychotic treatment
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PRKAR2B mRNAaffects expression 17562736
D000242 Cyclic AMP Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]affects binding|decreases reaction 11907174
D000242 Cyclic AMP Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2B protein]affects binding|increases reaction 11907174
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of PRKAR2B mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKAR2B mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of PRKAR2B mRNAdecreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PRKAR2B mRNAincreases expression 20106945
18247414
C095105 bexarotene bexarotene results in decreased expression of PRKAR2B mRNAdecreases expression 16648578
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRKAR2B mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PRKAR2B mRNAincreases expression 12832660
D004390 Chlorpyrifos Chlorpyrifos affects the expression of PRKAR2B mRNAaffects expression 17452286
D003024 Clozapine Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2B protein]affects binding|decreases reaction 11907174
D003024 Clozapine Clozapine results in decreased expression of PRKAR2B mRNAdecreases expression 15860345
11907174
D003024 Clozapine Clozapine results in decreased expression of PRKAR2B proteindecreases expression 11907174
D016572 Cyclosporine Cyclosporine results in decreased expression of PRKAR2B mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of PRKAR2B mRNAdecreases expression 18042831
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRKAR2B mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PRKAR2B mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PRKAR2B mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PRKAR2B mRNAdecreases expression 15834898
12655037
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of PRKAR2B mRNAincreases expression 15954086
D006220 Haloperidol Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2B protein]affects binding|increases reaction 11907174
D006220 Haloperidol Haloperidol results in decreased expression of PRKAR2B mRNAdecreases expression 15860345
D006220 Haloperidol Haloperidol results in increased expression of PRKAR2B mRNAincreases expression 11907174
D006220 Haloperidol Haloperidol results in increased expression of PRKAR2B proteinincreases expression 11907174
C008493 methylselenic acid methylselenic acid results in increased expression of PRKAR2B mRNAincreases expression 18548127
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of PRKAR2B mRNAincreases expression 12832660
D009538 Nicotine Nicotine results in increased expression of PRKAR2B mRNAincreases expression 18247414
C041786 palm oil palm oil results in decreased expression of PRKAR2B mRNAdecreases expression 18042831
D010795 Phthalic Acids Phthalic Acids results in decreased expression of PRKAR2B mRNAdecreases expression 15728792
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKAR2B mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite results in increased expression of PRKAR2B proteinincreases expression 19072884
D013654 Taurine Taurine results in decreased expression of PRKAR2B mRNAdecreases expression 16579726
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRKAR2B mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PRKAR2B mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKAR2B mRNAincreases expression 20106945
C052342 topiramate topiramate results in decreased expression of PRKAR2B mRNAdecreases expression 16979414
D014635 Valproic Acid Valproic Acid results in increased expression of PRKAR2B mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5515322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.558875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.6511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6514692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.516695378
MESH:D000236 Adenoma Ethylnitrosourea 6.516695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D000380 Agranulocytosis Clozapine 4.8314617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.1216611668 17119214 11874814
MESH:D000437 Alcoholism topiramate 4.8518552399 17925516 19331489
MESH:D000544 Alzheimer Disease Nicotine 3.2316627626
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2120106747
MESH:D001321 Autistic Disorder Acetaminophen 2.1618445737
MESH:D001321 Autistic Disorder Haloperidol 2.1618080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.1618316065 18775368 17688650 15238991 18985861 18940202 18558336 16609825 17507914 18396377 18177632 17157402 19460635 19232924 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 2.9620046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6814991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0916436596 15144691 16651633 18412241 16357521
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2617474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 2.2616344269 16818667
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D001943 Breast Neoplasms Estradiol 2.2617289903 16675129 18497071 19861407 14630087 17261762 12948864 17018787
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5616227642 16124888 16192424 15673190 16050911 16011737 18705752 3786805 10355542 15700767 15721981 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.243084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.2418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.2416924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.2415276417 16507464 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1516247446
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3720419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.3718572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2416120746 18850075 18670907
MESH:D002375 Catalepsy Haloperidol 4.681977408 15215559
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.7812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.7818566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 14.7816003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7819524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7517160924
MESH:D002659 Child Development Disorders, Pervasive topiramate 6.1415650499
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 6.1420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.9712912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 17.907624871 15913567 15500046 18164287 16629650 19486331 12927374 18590720
MESH:D002779 Cholestasis Cyclosporine 17.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9017110522 16919318 17681005 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 17.9019176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.6219407337 10220858
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0116354765 12621046 8697196 15340226 15668235
MESH:D003072 Cognition Disorders Clozapine 4.7417123785
MESH:D003110 Colonic Neoplasms arsenite 2.5515037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4016575769 17688650 8888407
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.6320210726
MESH:D003704 Dementia Haloperidol 4.3711575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.0316402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0317107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 7.0316979414
MESH:D058065 Diabetic Cardiomyopathies Taurine 5.8216025228
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3215331141
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 14.367624871 17522070 20133375 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.3614725611 11743745 12958197 10663392 19420014 11739529 17906064 12594235 11461765 10915739 10774834 12540782 16081117 14550746 16177239 15619225 12392966 19164858 17522070 16485898 19416960 12153990 11421492 19739265 12705907 11529661 14986274 11287661 16109766 19370779 16781746 17562736 11834606 19923254 18071297 18713872 19085960 2444490 16227642 16393943 15968718
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.3610092053 16177239 3786805 21278145 4309450 7440962 6623471 15027814 15998439 10915739 9327722 19085960 7120509 15968718 11566570 2869522 16227642 7179309 19336974 17522070 3732212 6884620
MESH:D056486 Drug-Induced Liver Injury Taurine 14.369328219
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.3620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.3619641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D050171 Dyslipidemias Clozapine 8.3316402076
MESH:D050171 Dyslipidemias Dietary Fats 8.3318367378
MESH:D004421 Dystonia Valproic Acid 3.841851702
MESH:D020821 Dystonic Disorders Nicotine 5.7017881519
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7518357618
MESH:D004487 Edema pirinixic acid 5.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9712538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.8311473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.933659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.693922381 16628512
MESH:D004827 Epilepsy topiramate 6.8019148780
MESH:D004827 Epilepsy Valproic Acid 6.8018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.406426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.077750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.0416499746
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.843659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver arsenite 33.8218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.8212631006 16045604 12795759 16239168 15959796 19224547 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 33.8219224547
MESH:D005234 Fatty Liver Dietary Fats 33.8218296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.8215345470
MESH:D005234 Fatty Liver pirinixic acid 33.8220131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 33.8214986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9118558336 8888407
MESH:D005355 Fibrosis arsenite 25.3418296743
MESH:D005355 Fibrosis Carbon Tetrachloride 25.3418705752
MESH:D005355 Fibrosis Cyclosporine 25.3412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 25.3418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.3420067830
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Ethylnitrosourea 3.6816436596
MESH:D005910 Glioma Ethylnitrosourea 3.4016357521 18412241 16651633
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.9318590720
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.5219176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5215340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8118606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006948 Hyperkinesis Clozapine 4.6816046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007248 Infertility, Male sodium arsenite 6.1412646999 15346721
MESH:D007249 Inflammation Dietary Fats 4.5320412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 11.4411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.4416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 11.4416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 13.3418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 13.3415618244
MESH:D007674 Kidney Diseases sodium arsenite 13.3420008137
MESH:D007680 Kidney Neoplasms Cyclosporine 11.4312371664
MESH:D007680 Kidney Neoplasms Estradiol 11.4315610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.4317379185
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1116294345 17596541
MESH:D008064 Lipidoses Clozapine 3.8017567588
MESH:D008103 Liver Cirrhosis arsenite 10.3718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.3716221502 16943688 16239168 17157831 17334410 17174718 11408273 11903743 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3718296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4318420326 15673190 18006644 18339082 18205269 17766677 18156304 18210741 17481882 18472332 18429990 16248980 18263696 16015684 20821823 15931870 17698563 17708605 17721639 17761835 18705752 15362042 15057751 18395914 15925388 18376398 18054572 18251166 17525996 12666154 18395095 17823541 16136751 15818738 18166357 18412020 18279442 15338365 15893842 16192424 16033810 16638106 17640975 12632512 16097048 17922224 18418968 17714472 15876570 14748882 17976157 12958196 16116963 18277467 12445421 17557913 17900296 12898905 14620537 12632514 12741479 17805973 12389079 15123356 17869086 17631135 17944888 18187930 14724832 15996030 16027843 12586293 12445418 12546737 15650968 15730626 15959796 14716496 18481824 13678700 15052691 17565644 18317297 10355542 15370692 18472094 12667390 14512876 12649538 11481614 12609069 14716833 16011737
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Taurine 6.4315931870 15893842
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4312878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 8.9617184895
MESH:D008107 Liver Diseases Acetaminophen 8.9619784758 12969438 12587719 19460945 11587558 19014921 16611625 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9617285989 16964402 16246199 15720792 15830285
MESH:D008107 Liver Diseases Chlorpyrifos 8.9615991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.7516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.7514706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.2921137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.2919294768
MESH:D008113 Liver Neoplasms pirinixic acid 13.2920007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 13.2916712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.2916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.2915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.2912151625
MESH:D008171 Lung Diseases sodium arsenite 3.0219095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D008175 Lung Neoplasms arsenite 8.1816809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.1820064080 18816296 18520028 18569708 17053015 20464547 20869020 6695378 20135361
MESH:D008175 Lung Neoplasms bexarotene 8.1817849452
MESH:D008175 Lung Neoplasms Ethylnitrosourea 8.1816271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms sodium arsenite 8.1816712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1811884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 3.7815790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8215375218
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.3215591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.3217203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 9.3210767621 10838139 18041768
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008545 Melanoma sodium arsenite 2.0016487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008579 Meningioma Ethylnitrosourea 5.7517943659
MESH:D001523 Mental Disorders Clozapine 7.6116856516
MESH:D001523 Mental Disorders Haloperidol 7.6116856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.2319142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008881 Migraine Disorders topiramate 7.5216942474 18803445 18759728 18765137
MESH:D008881 Migraine Disorders Valproic Acid 7.5218803445 18765137
MESH:D020326 Migraine without Aura Cyclic AMP 4.9411304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9711141357
MESH:D009369 Neoplasms Nicotine 10.9716365874
MESH:D009369 Neoplasms pirinixic acid 10.9717405874
MESH:D009369 Neoplasms sodium arsenite 10.9711559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.6316707424
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.6320056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5519196722
MESH:D009389 Neovascularization, Pathologic arsenite 15.7915738583
MESH:D009389 Neovascularization, Pathologic Estradiol 15.7917289903
MESH:D009389 Neovascularization, Pathologic Nicotine 15.7916365874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.7411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7414600291
MESH:D009436 Neural Tube Defects sodium arsenite 6.8512854658
MESH:D009436 Neural Tube Defects Valproic Acid 6.858888407 16359493
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1916003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0115081274
MESH:D009765 Obesity Clozapine 7.1218515891 19142110
MESH:D009765 Obesity Dietary Fats 7.1220518802 18457598 17217161 21332399 20132043 19632207 18674790 11836018 16723640
MESH:D009765 Obesity pirinixic acid 7.1220558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7517160924
MESH:D010051 Ovarian Neoplasms Estradiol 4.5919401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.5917306315 15276417
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 13.0220133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 13.0212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0312371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7011118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.7020603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1317292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1316205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1316039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.0915861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.3111422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.7311575062
MESH:D011618 Psychotic Disorders Clozapine 8.6215331141
MESH:D011618 Psychotic Disorders Haloperidol 8.6211575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.4111874814 17119214 16611668
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.6616611668 17119214
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9619155313
MESH:D012559 Schizophrenia Clozapine 5.5017726453 17667964 18806925 11151749 20580759 19369910 11763009 18855531 20521326 20107430 20452607 17123785 16141801 20521320 20168265
MESH:D012559 Schizophrenia Haloperidol 5.5018513383 19369910 1830565 20107430
MESH:D012559 Schizophrenia Valproic Acid 5.5019110320 15737665
MESH:D012640 Seizures Nicotine 9.3117873105
MESH:D012640 Seizures topiramate 9.3116499746
MESH:D012640 Seizures Valproic Acid 9.313137016 16876388 14763951 17978042 11044598 15475178 11738929 1511512
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.866418539
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7719755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 8.7718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.9712854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.9719490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.4920210726
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.5620133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9315790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5611259349 16720336 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.2215735609 18041664 18305452 17979512
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 7.9611144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9617053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.9616452187 11723127 17306315 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0814692618
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Clozapine 9.1916141801 20107430 20521320 17502770 20564506 16402076
MESH:D015430 Weight Gain Dietary Fats 9.1916723640
MESH:D015431 Weight Loss Clozapine 4.8517933447
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04210 Apoptosis
REACT:152 Cell Cycle, Mitotic
REACT:15380 Diabetes pathways
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
REACT:1505 Integration of energy metabolism
REACT:15295 Opioid Signalling
REACT:11061 Signalling by NGF
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33758
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA449396dopamine
    PA449773glucose
    PA164743471adenosine triphosphate
    PA448334alprostadil
    PA449470epinephrine
    PA164744376adenosine monophosphate
    PA451123progesterone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02527 - Cyclic Adenosine Monophosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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