AutismKB 2.0

Annotation Detail for EXOC2


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Basic Information Top
Gene Symbol:EXOC2 ( FLJ11026,SEC5,SEC5L1,Sec5p )
Gene Full Name: exocyst complex component 2
Band: 6p25.3
Quick LinksEntrez ID:55770; OMIM: NA; Uniprot ID:EXOC2_HUMAN; ENSEMBL ID: ENSG00000112685; HGNC ID: 24968
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200012Insulin Pathway
200046Arf6 trafficking events
Pathway IDPathway Name
P04393Ras Pathway
Pathway IDPathway Name
500128Insulin Synthesis and Processing
Related Diseases/Disorders Top
No data
No data
Desease Name
Black vs red hair color
tanning
Black vs blond hair color
Desease Name
Tanning
Freckles
Black vs. red hair color
Black vs. blond hair color
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of EXOC2 mRNAaffects expression 21346803
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of EXOC2 mRNAdecreases expression 17327690
D000643 Ammonium Chloride Ammonium Chloride affects the expression of EXOC2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EXOC2 mRNAdecreases expression 20106945
C011890 kojic acid kojic acid results in increased expression of EXOC2 mRNAincreases expression 16595896
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0421346803 18551238
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2816705839
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1420195826 21137059
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.5318544905
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720064080 20464547 17053015 18569708 6695378 18816296 20135361 18520028 20869020
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7812819281 16049721
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5119755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3516049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3517053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134862170
  • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018