AutismKB 2.0

Annotation Detail for FGD6


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Basic Information Top
Gene Symbol:FGD6 ( ZFYVE24 )
Gene Full Name: FYVE, RhoGEF and PH domain containing 6
Band: 12q22
Quick LinksEntrez ID:55785; OMIM: 613520; Uniprot ID:FGD6_HUMAN; ENSEMBL ID: ENSG00000180263; HGNC ID: 21740
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FGD6 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of FGD6 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FGD6 mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of FGD6 mRNAincreases expression 17484886
D005472 Fluorouracil FGD6 protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of FGD6 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of FGD6 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FGD6 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FGD6 mRNAincreases expression 15328365
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of FGD6 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5520464547 20127859
MESH:D000230 Adenocarcinoma Fluorouracil 4.5517638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000419 Albuminuria Raloxifene 4.8317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Fluorouracil 9.3317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.3311748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.3815136595 16595493 16557594 18608205 19217205 18357371 16110121
MESH:D001943 Breast Neoplasms Raloxifene 2.3817893378 17952589 15758505 17261762 15572757 15775269 16912660 17440819 17242785 17049068 16837676 17595753
MESH:D001943 Breast Neoplasms Tamoxifen 2.3811161223 19189212 19066611 18629630 20135344 15668708 16818667 20544844 20005174 19115204 18984771 19155303 20065188 19142967 18997820 19189210 17242785 18855134 18821012 19487384 19289846 19221464 19288272 19084267 19059307 19011961 20859285 18815881 17440819 17893378 18425577 16202921 21138602 15565566 19244106 18351453 20390343 17049068 16873071 16273361 19410462 19103187 19200415 21152245 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0416050911 15673190 16011737 15700767 16097048 16227642 16192424 15721981 10355542 16124888 18705752 3786805
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9916051944
MESH:D002277 Carcinoma Fluorouracil 8.7417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.803084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8018788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8016332177 17088986 17045692 18930000 16799960 17971768
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8016924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1018695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8116757204 18986760 16280240 17066447
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.1517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 16354765 8697196 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616510598 18772588 17725105 17287894 15001691 17016597 17169374 16340194 17018589 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017255274 18802399 18288408 16282729 16391804 17695437 15289873 20501625 14970324 16524972 17594712 16331619 17016601 16303861 18448328 17401013 18949393 15148649 18383874 17454858 17094418 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 5.0816733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.5416684804
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6517451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6519279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4311739529 11834606 19164858 16177239 10774834 16781746 14550746 11461765 2444490 16227642 12153990 12705907 12594235 19085960 19923254 16081117 16393943 19739265 17562736 15968718 11529661 17906064 19370779 14986274 16485898 18713872 12540782 10915739 11743745 18071297 10663392 14725611 11421492 19416960 19420014 16109766 12958197 11287661 15619225 12392966 17522070
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.4311566570 15027814 19085960 10092053 21278145 7120509 7440962 6884620 16177239 6623471 16227642 15998439 10915739 3786805 4309450 7179309 9327722 3732212 19336974 17522070 2869522 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Raloxifene 7.5415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 19155303 17893378 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6416785472 16337965 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.4412631006 61145 15959796 19224547 12795759 17595544 16239168 16045604
MESH:D005234 Fatty Liver Raloxifene 14.4417473493
MESH:D005234 Fatty Liver Tamoxifen 14.4419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.4720067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005910 Glioma Fluorouracil 2.9416145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5215102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8319110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8216899240
MESH:D006973 Hypertension Raloxifene 5.4515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3515338365
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 8.0916985049
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0918625569
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9111408273 11903743 21278145 17157831 16943688 17334410 16221502 16239168 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5515052691 14748882 15370692 18472332 17698563 18395914 16097048 16248980 15931870 17714472 16638106 18412020 16136751 17805973 14620537 18376398 17922224 12666154 17481882 17823541 12389079 12445418 12649538 18210741 18006644 16015684 15925388 14716496 17869086 17708605 14512876 18251166 18472094 18277467 17900296 15673190 18429990 15338365 18339082 18054572 12632512 17761835 14724832 15818738 12609069 12445421 15730626 15876570 15057751 12741479 12958196 15996030 17640975 18279442 16027843 12632514 17721639 18418968 15959796 17525996 14716833 17944888 18317297 12546737 18395095 18705752 10355542 12586293 18187930 13678700 17565644 17976157 15893842 17631135 15650968 12898905 18156304 18263696 18166357 16116963 16011737 11481614 18481824 18420326 12667390 17766677 18205269 16192424 15362042 20821823 17557913 16033810 15123356
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519460945 11587558 16610002 16611625 19784758 12587719 19014921 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0517285989 16964402 15720792 15830285 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.0614706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9821137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.9819294768
MESH:D008113 Liver Neoplasms Fluorouracil 14.9816603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms Tamoxifen 14.9816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9816984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0020064080 20135361 18520028 18816296 20869020 6695378 17053015 20464547 18569708
MESH:D008175 Lung Neoplasms Fluorouracil 5.0015246190
MESH:D008175 Lung Neoplasms Tamoxifen 5.0018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0011884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0815086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7416827153 19196722 19196723 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0616381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.0616757204 18986760
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3711141357
MESH:D009369 Neoplasms Fluorouracil 5.3718600527 18239605 16928823
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219196722 19189210 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5716436463
MESH:D010024 Osteoporosis Raloxifene 3.5117882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517823083 15579764 17893378 15758505
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7219003803 16929163 16500647 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0618626508 19082440
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0615731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1918286688 15538739 18722050 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4620155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4617172411 16424979 18567086 17522103 19015929 17498489 19084572 18396642 15786421 16951190
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Raloxifene 5.5319048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7617053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.7617572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7616712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0716803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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