AutismKB 2.0

Annotation Detail for PRKCB


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Basic Information Top
Gene Symbol:PRKCB ( MGC41878,PKC-beta,PKCB,PRKCB1,PRKCB2 )
Gene Full Name: protein kinase C, beta
Band: 16p12.2-p12.1
Quick LinksEntrez ID:5579; OMIM: 176970; Uniprot ID:KPCB_HUMAN; ENSEMBL ID: ENSG00000166501; HGNC ID: 9395
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04270Vascular smooth muscle contraction
hsa04973Carbohydrate digestion and absorption
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa05140Leishmaniasis
hsa05146Amoebiasis
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04530Tight junction
hsa04960Aldosterone-regulated sodium reabsorption
hsa04971Gastric acid secretion
hsa05223Non-small cell lung cancer
hsa05214Glioma
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04070Phosphatidylinositol signaling system
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05110Vibrio cholerae infection
Related Diseases/Disorders Top
Desease Name
nephropathy, diabetic
RENAL
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [EGF protein affects the localization of PRKCB protein]affects localization|decreases reaction 17991733
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PRKCB mRNAaffects expression 21346803
C500067 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol binds to and results in decreased activity of PRKCB proteinaffects binding|decreases activity 15771433
C059539 4'-N-benzoylstaurosporine 4'-N-benzoylstaurosporine results in decreased activity of PRKCB proteindecreases activity 15542774
D000079 Acetaldehyde PRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]affects reaction|decreases reaction|increases transport 17991733
D000079 Acetaldehyde PRKCB protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde]affects reaction|decreases response to substance 17991733
D000082 Acetaminophen Acetaminophen affects the expression of PRKCB mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PRKCB mRNAincreases expression 15120968
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|decreases reaction 16797713
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKCB mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of PRKCB proteindecreases expression 16483693
D000661 Amphetamine Amphetamine affects the expression of PRKCB mRNAaffects expression 16101753
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PRKCB mRNAdecreases expression 15725085
C015001 arsenite arsenite results in decreased expression of PRKCB mRNAdecreases expression 18191166
D001205 Ascorbic Acid Ascorbic Acid results in increased expression of PRKCB mRNAincreases expression 15305145
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRKCB mRNAdecreases expression 20064835
D020001 1-Butanol 1-Butanol affects the localization of PRKCB proteinaffects localization 15067001
D020001 1-Butanol 1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D002118 Calcium Calcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D002118 Calcium Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D007631 Chlordecone Calcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D007631 Chlordecone Chlordecone results in increased activity of PRKCB proteinincreases activity 1724372
D007631 Chlordecone Phosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D002794 Choline Choline affects the expression of PRKCB mRNAaffects expression 17264169
D002794 Choline Choline affects the expression of PRKCB proteinaffects expression 17264169
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]decreases reaction|increases expression 19172522
D003024 Clozapine Clozapine affects the expression of PRKCB proteinaffects expression 15967061
D003024 Clozapine Clozapine results in increased expression of PRKCB mRNAincreases expression 15860345
D003513 Cycloheximide Cycloheximide results in decreased expression of PRKCB mRNAdecreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PRKCB mRNAaffects cotreatment|increases expression 19684285
C004742 daidzein daidzein results in increased activity of PRKCB proteinincreases activity 16972265
D004010 Dicofol Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D004010 Dicofol Dicofol results in increased activity of PRKCB proteinincreases activity 1724372
D004010 Dicofol Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D004052 Diethylnitrosamine Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB proteinincreases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRKCB mRNAincreases expression 16636312
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRKCB mRNAincreases expression 17005392
D004958 Estradiol Estradiol results in decreased expression of PRKCB mRNAdecreases expression 20068009
D000431 Ethanol [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]increases abundance|increases activity|increases localization|increases reaction 10651808
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRKCB mRNAincreases expression 17351261
D005419 Flavonoids Flavonoids results in decreased expression of PRKCB mRNAdecreases expression 18035473
D016666 Fluvoxamine [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB proteinaffects cotreatment|affects expression 15967061
C039281 furan furan results in decreased expression of PRKCB mRNAdecreases expression 15120968
C081021 Go 6976 Go 6976 results in decreased activity of PRKCB proteindecreases activity 15767308
D006220 Haloperidol [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB proteinaffects cotreatment|affects expression 15967061
D006220 Haloperidol Haloperidol results in increased expression of PRKCB mRNAincreases expression 15860345
C007946 hispidin hispidin results in decreased activity of PRKCB proteindecreases activity 16374459
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the localization of and results in increased activity of PRKCB proteinaffects localization|increases activity 12821678
D007213 Indomethacin Indomethacin results in decreased expression of PRKCB protein alternative formdecreases expression 10702201
D007213 Indomethacin Indomethacin results in increased expression of PRKCB protein alternative formincreases expression 10702201
D007213 Indomethacin PRKCB protein alternative form results in decreased susceptibility to Indomethacindecreases response to substance 10702201
D007444 Inulin PRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]affects reaction|decreases reaction|increases transport 17991733
C051890 irinotecan irinotecan metabolite results in increased phosphorylation of PRKCB proteinincreases phosphorylation 15723263
C051890 irinotecan irinotecan results in increased phosphorylation of PRKCB proteinincreases phosphorylation 15723263
D007854 Lead Lead results in decreased expression of PRKCB proteindecreases expression 16547843
C008261 lead acetate lead acetate results in decreased expression of PRKCB proteindecreases expression 16547843
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]decreases reaction|increases expression 19172522
D008701 Methapyrilene Methapyrilene results in decreased expression of PRKCB mRNAdecreases expression 15120968
D008727 Methotrexate Methotrexate results in increased expression of PRKCB mRNAincreases expression 15120968
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRKCB mRNAincreases expression 19285098
C008493 methylselenic acid methylselenic acid results in increased expression of PRKCB mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas results in decreased expression of PRKCB mRNAdecreases expression 15674843
C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]affects localization|decreases reaction 16818790
D010656 Phenylephrine Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]affects binding|increases reaction 17121852
D010656 Phenylephrine Phenylephrine results in increased expression of PRKCB proteinincreases expression 17121852
D010656 Phenylephrine RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]decreases reaction|increases expression 17121852
D010718 Phosphatidylserines Phosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D010718 Phosphatidylserines Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D012643 Selenium Selenium results in decreased expression of PRKCB mRNAdecreases expression 19244175
D013481 Superoxides [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]increases abundance|increases activity|increases localization|increases reaction 10651808
D020002 tert-Butyl Alcohol tert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PRKCB mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKCB mRNAincreases expression 19684285
11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKCB mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|affects reaction 16797713
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|decreases reaction 16797713
D013749 Tetrachlorodibenzodioxin GNB2L1 protein affects the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|affects reaction 16797713
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the localization of PRKCB proteinaffects localization 16797713
D013755 Tetradecanoylphorbol Acetate [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]increases abundance|increases activity|increases localization|increases reaction 10651808
D013755 Tetradecanoylphorbol Acetate PRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]affects localization|affects reaction 16495082
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of PRKCB proteinaffects localization 15976015
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB proteindecreases phosphorylation 15380616
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of PRKCB proteinincreases activity 1724372
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased localization of PRKCB proteinincreases localization 15843515
D019284 Thapsigargin Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein]affects localization|decreases reaction 17991733
D019284 Thapsigargin 1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D019284 Thapsigargin tert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D019284 Thapsigargin Thapsigargin results in increased localization of PRKCB proteinincreases localization 15843515
D013827 Thiabendazole Thiabendazole results in increased expression of PRKCB mRNAincreases expression 18539377
D013893 Thiram Thiram results in decreased activity of PRKCB proteindecreases activity 15998240
D014212 Tretinoin Tretinoin results in increased expression of PRKCB mRNAincreases expression 16054129
D015032 Zinc PRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]affects localization|affects reaction 16495082
D015032 Zinc Zinc promotes the reaction [FCER1A protein affects the localization of PRKCB protein]affects localization|increases reaction 16818790
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33761
    • Releated disease ID Related disease Name
    PA128406954Weight gain
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445062Neoplasms
    PA443560Breast Neoplasms
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00163 - Vitamin E Dietary supplement;Micronutrient;Antioxidants;Vitamins/minerals;Vitamins
    DB01738 - O-Phosphoethanolamine

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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