AutismKB 2.0

Annotation Detail for PRKCB


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Basic Information Top
Gene Symbol:PRKCB ( MGC41878,PKC-beta,PKCB,PRKCB1,PRKCB2 )
Gene Full Name: protein kinase C, beta
Band: 16p12.2-p12.1
Quick LinksEntrez ID:5579; OMIM: 176970; Uniprot ID:KPCB_HUMAN; ENSEMBL ID: ENSG00000166501; HGNC ID: 9395
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04270Vascular smooth muscle contraction
hsa04973Carbohydrate digestion and absorption
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04010MAPK signaling pathway
hsa04720Long-term potentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04020Calcium signaling pathway
hsa05140Leishmaniasis
hsa05146Amoebiasis
hsa04310Wnt signaling pathway
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04530Tight junction
hsa04960Aldosterone-regulated sodium reabsorption
hsa04971Gastric acid secretion
hsa05223Non-small cell lung cancer
hsa05214Glioma
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa04070Phosphatidylinositol signaling system
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Hemostasis
Pathway IDPathway Name
200184Downstream signaling in naive CD8+ T cells
200003Fc-epsilon receptor I signaling in mast cells
200004Endothelins
200129JNK signaling in the CD4+ TCR pathway
200151VEGFR1 specific signals
200088Ras signaling in the CD4+ TCR pathway
200082IL2-mediated signaling events
200069Thromboxane A2 receptor signaling
200062TCR signaling in naive CD8+ T cells
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200161Signaling events mediated by VEGFR1 and VEGFR2
200022TCR signaling in naive CD4+ T cells
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00056VEGF signaling pathway
P00019Endothelin signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00018EGF receptor signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P00005Angiogenesis
P043745HT2 type receptor mediated signaling pathway
P00010B cell activation
P00006Apoptosis signaling pathway
P00021FGF signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00041Metabotropic glutamate receptor group I pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
nephropathy, diabetic
RENAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [EGF protein affects the localization of PRKCB protein]affects localization|decreases reaction 17991733
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PRKCB mRNAaffects expression 21346803
C500067 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol 3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol binds to and results in decreased activity of PRKCB proteinaffects binding|decreases activity 15771433
C059539 4'-N-benzoylstaurosporine 4'-N-benzoylstaurosporine results in decreased activity of PRKCB proteindecreases activity 15542774
D000079 Acetaldehyde PRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]affects reaction|decreases reaction|increases transport 17991733
D000079 Acetaldehyde PRKCB protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde]affects reaction|decreases response to substance 17991733
D000082 Acetaminophen Acetaminophen affects the expression of PRKCB mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PRKCB mRNAincreases expression 15120968
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|decreases reaction 16797713
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRKCB mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of PRKCB proteindecreases expression 16483693
D000661 Amphetamine Amphetamine affects the expression of PRKCB mRNAaffects expression 16101753
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PRKCB mRNAdecreases expression 15725085
C015001 arsenite arsenite results in decreased expression of PRKCB mRNAdecreases expression 18191166
D001205 Ascorbic Acid Ascorbic Acid results in increased expression of PRKCB mRNAincreases expression 15305145
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PRKCB mRNAdecreases expression 20064835
D020001 1-Butanol 1-Butanol affects the localization of PRKCB proteinaffects localization 15067001
D020001 1-Butanol 1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D002118 Calcium Calcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D002118 Calcium Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D007631 Chlordecone Calcium inhibits the reaction [Chlordecone results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D007631 Chlordecone Chlordecone results in increased activity of PRKCB proteinincreases activity 1724372
D007631 Chlordecone Phosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D002794 Choline Choline affects the expression of PRKCB mRNAaffects expression 17264169
D002794 Choline Choline affects the expression of PRKCB proteinaffects expression 17264169
C055162 clopidogrel clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]decreases reaction|increases expression 19172522
D003024 Clozapine Clozapine affects the expression of PRKCB proteinaffects expression 15967061
D003024 Clozapine Clozapine results in increased expression of PRKCB mRNAincreases expression 15860345
D003513 Cycloheximide Cycloheximide results in decreased expression of PRKCB mRNAdecreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PRKCB mRNAaffects cotreatment|increases expression 19684285
C004742 daidzein daidzein results in increased activity of PRKCB proteinincreases activity 16972265
D004010 Dicofol Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]decreases reaction|increases activity 1724372
D004010 Dicofol Dicofol results in increased activity of PRKCB proteinincreases activity 1724372
D004010 Dicofol Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D004052 Diethylnitrosamine Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB proteinincreases activity|increases phosphorylation 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of PRKCB protein]decreases reaction|increases activity|increases phosphorylation 17942915
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRKCB mRNAincreases expression 16636312
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PRKCB mRNAincreases expression 17005392
D004958 Estradiol Estradiol results in decreased expression of PRKCB mRNAdecreases expression 20068009
D000431 Ethanol [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]increases abundance|increases activity|increases localization|increases reaction 10651808
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PRKCB mRNAincreases expression 17351261
D005419 Flavonoids Flavonoids results in decreased expression of PRKCB mRNAdecreases expression 18035473
D016666 Fluvoxamine [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB proteinaffects cotreatment|affects expression 15967061
C039281 furan furan results in decreased expression of PRKCB mRNAdecreases expression 15120968
C081021 Go 6976 Go 6976 results in decreased activity of PRKCB proteindecreases activity 15767308
D006220 Haloperidol [Haloperidol co-treated with Fluvoxamine] affects the expression of PRKCB proteinaffects cotreatment|affects expression 15967061
D006220 Haloperidol Haloperidol results in increased expression of PRKCB mRNAincreases expression 15860345
C007946 hispidin hispidin results in decreased activity of PRKCB proteindecreases activity 16374459
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the localization of and results in increased activity of PRKCB proteinaffects localization|increases activity 12821678
D007213 Indomethacin Indomethacin results in decreased expression of PRKCB protein alternative formdecreases expression 10702201
D007213 Indomethacin Indomethacin results in increased expression of PRKCB protein alternative formincreases expression 10702201
D007213 Indomethacin PRKCB protein alternative form results in decreased susceptibility to Indomethacindecreases response to substance 10702201
D007444 Inulin PRKCB protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]affects reaction|decreases reaction|increases transport 17991733
C051890 irinotecan irinotecan metabolite results in increased phosphorylation of PRKCB proteinincreases phosphorylation 15723263
C051890 irinotecan irinotecan results in increased phosphorylation of PRKCB proteinincreases phosphorylation 15723263
D007854 Lead Lead results in decreased expression of PRKCB proteindecreases expression 16547843
C008261 lead acetate lead acetate results in decreased expression of PRKCB proteindecreases expression 16547843
D008070 Lipopolysaccharides clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of PRKCB mRNA]decreases reaction|increases expression 19172522
D008701 Methapyrilene Methapyrilene results in decreased expression of PRKCB mRNAdecreases expression 15120968
D008727 Methotrexate Methotrexate results in increased expression of PRKCB mRNAincreases expression 15120968
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRKCB mRNAincreases expression 19285098
C008493 methylselenic acid methylselenic acid results in increased expression of PRKCB mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas results in decreased expression of PRKCB mRNAdecreases expression 15674843
C044387 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]affects localization|decreases reaction 16818790
D010656 Phenylephrine Phenylephrine promotes the reaction [RBCK1 protein binds to PRKCB protein]affects binding|increases reaction 17121852
D010656 Phenylephrine Phenylephrine results in increased expression of PRKCB proteinincreases expression 17121852
D010656 Phenylephrine RBCK1 protein inhibits the reaction [Phenylephrine results in increased expression of PRKCB protein]decreases reaction|increases expression 17121852
D010718 Phosphatidylserines Phosphatidylserines promotes the reaction [Chlordecone results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D010718 Phosphatidylserines Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]increases activity|increases reaction 1724372
D012643 Selenium Selenium results in decreased expression of PRKCB mRNAdecreases expression 19244175
D013481 Superoxides [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]increases abundance|increases activity|increases localization|increases reaction 10651808
D020002 tert-Butyl Alcohol tert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of PRKCB mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKCB mRNAincreases expression 19684285
11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRKCB mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|affects reaction 16797713
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|decreases reaction 16797713
D013749 Tetrachlorodibenzodioxin GNB2L1 protein affects the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]affects localization|affects reaction 16797713
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the localization of PRKCB proteinaffects localization 16797713
D013755 Tetradecanoylphorbol Acetate [Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides]increases abundance|increases activity|increases localization|increases reaction 10651808
D013755 Tetradecanoylphorbol Acetate PRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]affects localization|affects reaction 16495082
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate affects the localization of PRKCB proteinaffects localization 15976015
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB proteindecreases phosphorylation 15380616
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of PRKCB proteinincreases activity 1724372
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased localization of PRKCB proteinincreases localization 15843515
D019284 Thapsigargin Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein]affects localization|decreases reaction 17991733
D019284 Thapsigargin 1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D019284 Thapsigargin tert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCB protein]decreases reaction|increases localization 15843515
D019284 Thapsigargin Thapsigargin results in increased localization of PRKCB proteinincreases localization 15843515
D013827 Thiabendazole Thiabendazole results in increased expression of PRKCB mRNAincreases expression 18539377
D013893 Thiram Thiram results in decreased activity of PRKCB proteindecreases activity 15998240
D014212 Tretinoin Tretinoin results in increased expression of PRKCB mRNAincreases expression 16054129
D015032 Zinc PRKCB protein affects the reaction [Tetradecanoylphorbol Acetate affects the localization of Zinc]affects localization|affects reaction 16495082
D015032 Zinc Zinc promotes the reaction [FCER1A protein affects the localization of PRKCB protein]affects localization|increases reaction 16818790
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 10.9217676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 10.9212039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.9215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 8.4818287403
MESH:D000138 Acidosis Ethanol 8.4811192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3317505938
MESH:D000169 Acrodermatitis Zinc 4.8016889938 17190629 17202136
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.4019106084
MESH:D058186 Acute Kidney Injury Superoxides 4.5718460982
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.4811850527 18653653
MESH:D000230 Adenocarcinoma arsenic trioxide 14.5511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 14.5520127859 20464547
MESH:D000230 Adenocarcinoma daidzein 14.5511473722
MESH:D000230 Adenocarcinoma Estradiol 14.5511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 14.5514692618
MESH:D000230 Adenocarcinoma Indomethacin 14.5516537180
MESH:D000236 Adenoma Benzo(a)pyrene 9.036695378
MESH:D000236 Adenoma Diethylnitrosamine 9.0310737359 6695378
MESH:D000236 Adenoma Indomethacin 9.0311497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.0716434500 19052882 17162532 17620307 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.0716835633
MESH:D000380 Agranulocytosis Clozapine 4.4716160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Dicofol 4.8512584743
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7115451040 15451039
MESH:D000505 Alopecia Tretinoin 3.1315955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7617225004
MESH:D000544 Alzheimer Disease Indomethacin 3.9617627676 15579461
MESH:D000544 Alzheimer Disease Zinc 3.9616410023 16325427 16580781 17119284
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.4518475255 16916582 16459022 15010207
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4311748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.3316916123
MESH:D000756 Anemia, Sideroblastic Superoxides 5.0816910769
MESH:D000799 Angioedema Acetaminophen 3.2310982225
MESH:D000853 Anophthalmos Ethanol 4.2315513904
MESH:D000855 Anorexia Amphetamine 8.9212183048 16101753 16084549 12005258
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 8.9215146954
MESH:D001008 Anxiety Disorders Ethanol 3.5211141031
MESH:D001014 Aortic Aneurysm Indomethacin 4.2810231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 9.7619183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 9.7610388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.5917460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.8811256880
MESH:D018771 Arthralgia Indomethacin 4.562160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 5.8915885639
MESH:D001169 Arthritis, Experimental Tretinoin 5.8916412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.4611248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 6.4617286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.4616292516
MESH:D001249 Asthma Acetaldehyde 9.489600491
MESH:D001249 Asthma Mustard Gas 9.4810378619
MESH:D001249 Asthma Tretinoin 9.4816456186
MESH:D001249 Asthma Zinc 9.4817085522
MESH:D001259 Ataxia 1-Butanol 5.037820390
MESH:D001321 Autistic Disorder marker/mechanism 16027742
MESH:D001321 Autistic Disorder Acetaminophen 2.5818445737
MESH:D001321 Autistic Disorder Choline 2.5816818868
MESH:D001321 Autistic Disorder Fluvoxamine 2.5812607287 19232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 2.5819368416 18080171
MESH:D001471 Barrett Esophagus Tretinoin 3.8316935849
MESH:D001477 Bartter Syndrome Indomethacin 4.4010684365
MESH:D001768 Blister Mustard Gas 4.5619167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.2216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.2212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.2216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.1815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3615746008
MESH:D001919 Bradycardia Phenylephrine 3.9515306635
MESH:D001929 Brain Edema Indomethacin 4.4111481608
MESH:D001930 Brain Injuries Zinc 4.1017109824
MESH:D002545 Brain Ischemia Indomethacin 3.8212524144
MESH:D001943 Breast Neoplasms Ascorbic Acid 5.0016443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.0020146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.0017474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.0017129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 5.0017261762 17018787 19861407 14630087 17289903 16675129 12948864 18497071
MESH:D001943 Breast Neoplasms Indomethacin 5.0017401462
MESH:D001943 Breast Neoplasms Methotrexate 5.0016978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.0020435547
MESH:D001943 Breast Neoplasms Tretinoin 5.0016873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.3617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.9916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.7711589617
MESH:D002056 Burns Ethanol 9.4316374292
MESH:D002056 Burns Indomethacin 9.4310459503
MESH:D002100 Cachexia Indomethacin 4.4016537180 11239499 15625704 15141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5516168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 17.2016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.203084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 17.2015553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 17.2017162532 16698587 20514400 18978308 19418558 16540662 16502159 19394651 16328049 20007298 18393292 3581430 19539802 19519916 20512989 16288022 18056438 20524982 10737359 20935162 16878318 18785209 19919837 17173139 19208518 17428255 10672840 11831363 18788625 19822196 18691550 17138121 3084413 20084675 19383236 16779866 18665156 16807293 17761372 16830150 20101231 19335982 16935385 17978847 19107877 19171122 19052882 18506893 20214788 21159647 18971187 19701751 18494052 18210153 20727157 17055752 16569478 16681979 20432363
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 17.2015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 17.2016924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 17.2015289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 17.2016391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 17.201917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7518791128 14736730 11352223
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.2619014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.0617341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.5912490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.0020419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 12.0015482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 12.0018922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.0016096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 12.0016543248
MESH:D006332 Cardiomegaly marker/mechanism 17121852
MESH:D006332 Cardiomegaly Ethanol 9.3719332462
MESH:D006332 Cardiomegaly Phenylephrine 9.3715728586 16170337 11754973 11179087 17287366 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.3716120746 18670907 18850075
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 5.8710525098
MESH:D002318 Cardiovascular Diseases clopidogrel 13.9220180610
MESH:D002318 Cardiovascular Diseases daidzein 13.9216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 13.9216936243
MESH:D002318 Cardiovascular Diseases Zinc 13.9216936243
MESH:D002375 Catalepsy Haloperidol 4.3115215559 1977408
MESH:D002386 Cataract Acetaminophen 5.9610977129
MESH:D002386 Cataract Tretinoin 5.9617460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 8.696135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 8.697505956 17174075 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 8.6918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.9916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.6219052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.6216835633
MESH:D002764 Cholecystitis Indomethacin 4.5611181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.4215861022 17681005 17110522 11677210 16919318 17333356 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.5516461808
MESH:D002971 Cleft Lip Ethanol 3.2415513904
MESH:D002972 Cleft Palate Ethanol 8.1415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.1412621046 16354765 15340226 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 8.149407595
MESH:D003072 Cognition Disorders Clozapine 4.3817123785
MESH:D003092 Colitis Selenium 7.5617936198
MESH:D003092 Colitis Tretinoin 7.5617035595
MESH:D003110 Colonic Neoplasms arsenite 5.1215037631
MESH:D003110 Colonic Neoplasms Indomethacin 5.1215786552 11260862 15625704 15936596 15637740 15963497
MESH:D003110 Colonic Neoplasms irinotecan 5.1217725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.1420501625
MESH:D015179 Colorectal Neoplasms Indomethacin 3.1418059344 12606626 11197048 17054584
MESH:D015179 Colorectal Neoplasms irinotecan 3.1416303861 17159606 15273666 16391804 18259882 18509181 17454858
MESH:D003139 Common Cold Ascorbic Acid 4.8617323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5514669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6112609071
MESH:D018352 Coronavirus Infections Indomethacin 5.1017302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 12.5510525206
MESH:D019465 Craniofacial Abnormalities Ethanol 12.5515451040 19302082 11198716 15451039 11873399 10194807 15513904
MESH:D019465 Craniofacial Abnormalities Lead 12.5519769572
MESH:D019465 Craniofacial Abnormalities lead acetate 12.5519769572
MESH:D019465 Craniofacial Abnormalities Methotrexate 12.5512039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 12.5520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 12.558800419 9125849 9224671 14991402 9211117 17551590 16925845 10589399 9142499 9664655
MESH:D019465 Craniofacial Abnormalities Zinc 12.5519302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 3.9912952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.4318551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.7219747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 9.0815213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 9.0820210726
MESH:D003704 Dementia Haloperidol 8.7411575062
MESH:D003704 Dementia Lead 8.7416140633
MESH:D003866 Depressive Disorder Fluvoxamine 4.9319571598
MESH:D003865 Depressive Disorder, Major Fluvoxamine 5.4517474826
MESH:D003882 Dermatomyositis Methotrexate 4.5520191521
MESH:D002658 Developmental Disabilities Choline 4.2516818868
MESH:D003920 Diabetes Mellitus Zinc 3.7016479319
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 11.6016506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 11.6016402076
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 11.6016647724
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 11.6020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 11.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9019279558
MESH:D003967 Diarrhea Indomethacin 3.247237001 7907874
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.9415331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3418551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3411739529 12958197 17562736 14986274 11461765 15619225 19164858 19085960 10663392 16081117 16485898 16227642 12392966 17522070 16393943 11421492 11529661 19739265 12705907 17906064 19416960 10774834 19923254 16109766 12153990 15968718 14725611 19420014 16781746 11834606 12540782 10915739 12594235 16177239 18071297 11287661 2444490 11743745 14550746 18713872 19370779
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.3419107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.3411566570
MESH:D056486 Drug-Induced Liver Injury Selenium 12.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.4919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5518446180 12774134 18043480 16326151 16133044 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.5717151854 11595431 17351913 11595415 17329845 17045617 11535926 10671773 11991626 16699067 17202747
MESH:D050171 Dyslipidemias Clozapine 3.7416402076
MESH:C538011 Eales disease Ascorbic Acid 4.869068938
MESH:D004487 Edema Indomethacin 12.158985016 7907874 7990266 16100529 19703484 8273558 10653021
MESH:D004487 Edema Mustard Gas 12.1511402378 11428631 11428647 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.1512711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 12.158113982 8273558 15177302 9599246 11698051 7812673 16716910
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.9116714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 9.9118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.6212538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.0916402032
MESH:D016889 Endometrial Neoplasms daidzein 14.4411473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 14.4415700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 14.4411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 14.4416569247
MESH:D004715 Endometriosis Indomethacin 7.3315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.3310568697 9294722
MESH:D019446 Endotoxemia Indomethacin 8.6618509659
MESH:D019446 Endotoxemia Lipopolysaccharides 8.6617637181 15821434 15328337
MESH:D004751 Enteritis Indomethacin 4.1416328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4017980183
MESH:D004802 Eosinophilia Indomethacin 3.4811298111
MESH:D007172 Erectile Dysfunction daidzein 4.4514972507
MESH:D004890 Erythema Mustard Gas 4.569357497
MESH:D004892 Erythema Multiforme Thiram 6.0416750123
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5016302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 11.7112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 11.7116530937
MESH:D004938 Esophageal Neoplasms Ethanol 11.7116704527
MESH:D004938 Esophageal Neoplasms Indomethacin 11.7111005569
MESH:D004938 Esophageal Neoplasms Zinc 11.7116543248
MESH:D020329 Essential Tremor Lead 5.3318007985 14594619
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.3011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.309664655 16938888
MESH:D005221 Fatigue Amphetamine 5.0019890266
MESH:D005234 Fatty Liver arsenic trioxide 18.9915073043
MESH:D005234 Fatty Liver arsenite 18.9918296743
MESH:D005234 Fatty Liver Diethylnitrosamine 18.9920387270 21071580
MESH:D005234 Fatty Liver Ethanol 18.9918620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.9915345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.0517920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.2616534752 15751030 16513791 16002989 16611131
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7016946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.8711858732
MESH:D005317 Fetal Growth Retardation Lead 9.8119769572
MESH:D005317 Fetal Growth Retardation lead acetate 9.8119769572
MESH:D005334 Fever Indomethacin 7.6110431976 17627676 11852909
MESH:D005334 Fever Lipopolysaccharides 7.6111852909 9205823
MESH:D005354 Fibrosarcoma Indomethacin 4.2910962813
MESH:D005355 Fibrosis arsenite 16.4318296743
MESH:D005355 Fibrosis Indomethacin 16.4317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.4320067830
MESH:D005355 Fibrosis Tretinoin 16.4317994277
MESH:D005499 Folliculitis Indomethacin 4.5611298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.6916904648
MESH:D005756 Gastritis Acetaminophen 22.3116983495
MESH:D005756 Gastritis Ethanol 22.3115046732
MESH:D005756 Gastritis Indomethacin 22.3115046732
MESH:D005756 Gastritis Zinc 22.3117241300
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3516452187
MESH:D005909 Glioblastoma Indomethacin 5.9512870263
MESH:D005909 Glioblastoma Tretinoin 5.9517312396
MESH:D005910 Glioma Indomethacin 2.9616487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8011849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.9810696789
MESH:D006073 Gout Indomethacin 4.7511248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.5616518429
MESH:D006130 Growth Disorders Zinc 3.5517217573
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.5115482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.5116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5516084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 13.1216080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.1211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 13.129664655 14991402
MESH:D006333 Heart Failure Selenium 6.0317162251
MESH:D006333 Heart Failure Zinc 6.0317162251
MESH:D006335 Heart Injuries Zinc 5.1617074742
MESH:D016481 Helicobacter Infections Zinc 3.9817241300
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.8616366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1115135802
MESH:D006527 Hepatolenticular Degeneration Zinc 4.1017276780
MESH:D006529 Hepatomegaly Dicofol 7.252387028
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2515340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.2316863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.4215709030
MESH:D006734 Horse Diseases Thiabendazole 5.6616402567
MESH:D019584 Hot Flashes Estradiol 3.1417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.438697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 14.7416870215
MESH:D006930 Hyperalgesia Ethanol 14.7418783367
MESH:D006930 Hyperalgesia Indomethacin 14.7412727271
MESH:D006930 Hyperalgesia Tretinoin 14.7416870215
MESH:D034321 Hyperamylasemia Indomethacin 5.1017883296
MESH:D006940 Hyperemia Indomethacin 4.4012524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.9816778211
MESH:D020138 Hyperhomocysteinemia Superoxides 4.7612615666
MESH:D006948 Hyperkinesis Amphetamine 9.8114960337 1977408
MESH:D006948 Hyperkinesis Clozapine 9.8116046005
MESH:D006949 Hyperlipidemias Indomethacin 3.6117546600
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8514722030 12960047
MESH:D006973 Hypertension daidzein 7.2517169123
MESH:D006973 Hypertension Phenylephrine 7.2512717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.2518850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.0118502941 12791704
MESH:D007021 Hypospadias Diethylstilbestrol 9.2916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.2916945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.4118306037 10574470
MESH:D007079 Ileitis Indomethacin 4.7516133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7616133044
MESH:D007246 Infertility Diethylstilbestrol 9.3815036965
MESH:D007246 Infertility Thiram 9.386420938
MESH:D007247 Infertility, Female Dicofol 8.8010631594 11762692
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.8012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.7617937319
MESH:D007248 Infertility, Male Lead 5.7616780224
MESH:D007249 Inflammation Diethylnitrosamine 18.9318785209
MESH:D007249 Inflammation Flavonoids 18.9317296493
MESH:D007249 Inflammation Indomethacin 18.9312568917 3291741 7812673
MESH:D007249 Inflammation Lipopolysaccharides 18.9312878042 17255318 17237260 9205823 17963957
MESH:D007249 Inflammation Mustard Gas 18.938975870 11402378 17524151 11428647 9357497 16001271 9260866 11428620 11428631
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.9312200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 18.9315177302 8273558 7562506 11698051 7812673
MESH:D007251 Influenza, Human Selenium 3.5916624496
MESH:D007333 Insulin Resistance Estradiol 2.5616393666 16627594
MESH:D007410 Intestinal Diseases Indomethacin 13.2711855677 11686837 15831440 10210152 17994277 15610444 11713966 18236018 17329856
MESH:D007410 Intestinal Diseases Superoxides 13.2710210152
MESH:D007410 Intestinal Diseases Tretinoin 13.2717994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.7615241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.0717255318
MESH:D007511 Ischemia Zinc 4.0516584753
MESH:D007569 Jaw Abnormalities Ethanol 14.0615513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.0616580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.0615992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.4116133968 10574470 18306037
MESH:D007674 Kidney Diseases Acetaminophen 11.4015629191 12587719
MESH:D007674 Kidney Diseases Estradiol 11.4015618244
MESH:D007674 Kidney Diseases Indomethacin 11.4017190690
MESH:D007674 Kidney Diseases Zinc 11.4016960431
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 13.6616518626
MESH:D007676 Kidney Failure, Chronic Selenium 13.6616518626
MESH:D007676 Kidney Failure, Chronic Zinc 13.6616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 9.6216705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 9.6215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 9.6215610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.4316316344
MESH:D007805 Language Development Disorders Methotrexate 4.549562676
MESH:D007855 Lead Poisoning Lead 5.3316700817
MESH:D007859 Learning Disorders Diethylstilbestrol 12.9217184923
MESH:D007859 Learning Disorders Ethanol 12.9215451040
MESH:D007859 Learning Disorders Lead 12.9216384672
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4112228301 10320625 11703811
MESH:D007938 Leukemia arsenic trioxide 5.2315070760
MESH:D007938 Leukemia Tretinoin 5.2317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.2617077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.0314633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.0315631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 7.6819077051
MESH:D007951 Leukemia, Myeloid Tretinoin 7.6816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.3116968895 17050201 16467208 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.3118360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.3116294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.2511161223 19642359 17217047 17649720 19075265 11468182 15336539 17107899 15622746 19035177 16330433 16891316 15748426 9834237 12679006 17712046 19225113 12712474 16331271 16823087 16966277 16112521 17869043 15213294 12018890
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.2519642359 19225113 17339181 17649720 16788101 16331271 19075265 15748426 19035177 16935935 16140955 17361223 17107899 17301526 9834237 16766008 17712046 17368321 17506722 17217047 17294898 16823087 12679006 19029980 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.7816882451
MESH:D007964 Leukocytosis Indomethacin 4.7616537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1017980183
MESH:D007970 Leukopenia Lipopolysaccharides 4.1015821434
MESH:D017880 Limb Deformities, Congenital Ethanol 6.8317676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.839224671
MESH:D008064 Lipidoses Clozapine 3.5217567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1011479899
MESH:D008103 Liver Cirrhosis arsenite 12.8618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 12.8619638242 18522880 18407596 20032147 18665156
MESH:D008103 Liver Cirrhosis Ethanol 12.8615289165
MESH:D008103 Liver Cirrhosis Methotrexate 12.8614986274
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5018295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 7.3818166357
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.3818194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 7.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.3818397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.2716610002 12969438 11587558 19784758 16611625 19014921 19460945 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 3.2717034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.0717347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.747678174
MESH:D008113 Liver Neoplasms arsenic trioxide 17.7414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.7421137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.7419426721 19256749 19254457 20137499 18977376 12771043 19551842 19996281 20101389 20492335 18648771 19642983 19850985 21047994 20452335 21167192 15175105 12112319 19812893 21278145 18978307 19638242 20118626 2862719 20434301 20583210 18754104 21071580 19294768 10737359 2422723 19427195 19690152 16942905 19090486 19073162 18644402 19833225 15885732 19255062 20501860 20405173 9163691 19499222
MESH:D008113 Liver Neoplasms Diethylstilbestrol 17.7415890375 16712894
MESH:D008113 Liver Neoplasms Methapyrilene 17.7415890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.7416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.436135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.4320377131
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 14.4318544905
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.4317854601 19126423 18079962 9362446 19004024 3124819 19009564 18308698 2563599 16842330 18544905 18164116 16267830 18282651 21159647 19519916 19539802 17942915 17174075 18775883 18253720 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 2.8915213294
MESH:D008171 Lung Diseases Ascorbic Acid 6.4216863852
MESH:D008171 Lung Diseases Mustard Gas 6.4218702808 18161513
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.4118516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.4321114838
MESH:D008175 Lung Neoplasms Acetaldehyde 15.5817372256
MESH:D008175 Lung Neoplasms arsenic trioxide 15.5811798837 19825857
MESH:D008175 Lung Neoplasms arsenite 15.5816809336
MESH:D008175 Lung Neoplasms Ascorbic Acid 15.5816401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.5820464547 18569708 20135361 17053015 20869020 18816296 20064080 18520028 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.5820970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Indomethacin 15.5811053908 11497255 16537180
MESH:D008175 Lung Neoplasms Mustard Gas 15.583148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.5811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 15.5811807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.4515700306
MESH:D008223 Lymphoma Methotrexate 6.4517352296
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9016002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.9811408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.9815318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 10.988985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.9812773700
MESH:D020149 Manganese Poisoning Estradiol 3.8719453300
MESH:D008527 Medulloblastoma Tretinoin 2.5117453147
MESH:D008545 Melanoma Tretinoin 1.8516752155
MESH:D008546 Melanoma, Experimental Acetaminophen 2.9819513568
MESH:D008569 Memory Disorders Ethanol 8.2318411066 15451040
MESH:D008569 Memory Disorders Lead 8.2316384672 17263510
MESH:D008591 Meningomyelocele Tretinoin 3.8416940565
MESH:D001523 Mental Disorders Clozapine 10.1216856516
MESH:D001523 Mental Disorders Fluvoxamine 10.1216856516
MESH:D001523 Mental Disorders Haloperidol 10.1216856516
MESH:D008654 Mesothelioma Selenium 2.5215107826
MESH:D024821 Metabolic Syndrome X Clozapine 3.9119142101
MESH:D008881 Migraine Disorders Indomethacin 3.2411903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.0916381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.0912636206
MESH:D052016 Mucositis irinotecan 10.6017159606
MESH:D052016 Mucositis Methotrexate 10.6017488658
MESH:D009101 Multiple Myeloma arsenic trioxide 2.6714977855 11468182 15949261 19417148 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.1516105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.1517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.8116810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.267678174 18551238
MESH:D009349 Nematode Infections Thiabendazole 5.8016402567
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.3916624393
MESH:D009362 Neoplasm Metastasis clopidogrel 11.3811875746
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.389029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 11.3816537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis irinotecan 11.3818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 6.3811141357
MESH:D009369 Neoplasms Diethylstilbestrol 6.3815313581
MESH:D009369 Neoplasms Tretinoin 6.3816946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 3.5610663608 15625704
MESH:D009389 Neovascularization, Pathologic arsenite 8.1615738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.1617289903
MESH:D009422 Nervous System Diseases Dicofol 5.171856875
MESH:D009421 Nervous System Malformations Diethylstilbestrol 18.7711399458
MESH:D009421 Nervous System Malformations Estradiol 18.7716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 18.7714600291
MESH:D009421 Nervous System Malformations Tretinoin 18.779125849
MESH:D009436 Neural Tube Defects arsenic trioxide 5.9310525206
MESH:D009436 Neural Tube Defects Tretinoin 5.939142499
MESH:D009447 Neuroblastoma irinotecan 3.148761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 16.0818514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 16.0815183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 16.0820387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 16.0812349958
MESH:D017599 Neuroectodermal Tumors irinotecan 4.138761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5020387270
MESH:D009503 Neutropenia Mustard Gas 3.4216761898 7688884
MESH:D009765 Obesity Ascorbic Acid 4.5617217161
MESH:D009765 Obesity Clozapine 4.5619142110 18515891
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.566374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 2.9116049721
MESH:D010003 Osteoarthritis Indomethacin 3.287009135
MESH:D010009 Osteochondrodysplasias Thiram 5.0615899490 17954590 15518828
MESH:D010024 Osteoporosis Calcium 3.3917882678
MESH:D010051 Ovarian Neoplasms arsenic trioxide 6.5112452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 6.5119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 6.5116936753
MESH:D010146 Pain Acetaminophen 8.4416870215
MESH:D010146 Pain Indomethacin 8.4417627676 3291741 17440234 13679232
MESH:D010146 Pain Tretinoin 8.4416870215
MESH:D010149 Pain, Postoperative Indomethacin 4.0712538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 13.5715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 13.5716540662
MESH:D010190 Pancreatic Neoplasms Ethanol 13.5712384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 13.5715976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.5715976015
MESH:D010195 Pancreatitis Indomethacin 3.3817883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1311578682
MESH:D010212 Papilloma Hydrogen Peroxide 7.6812065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 7.6812065085 18922899 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 3.6119927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1016537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1011903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6312520081
MESH:D010437 Peptic Ulcer Indomethacin 4.5511148446
MESH:D010518 Periodontitis Indomethacin 4.3017225004
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.5614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.0816977796 15687265
MESH:D010954 Plasmacytoma Selenium 4.2815087411
MESH:D011014 Pneumonia Lipopolysaccharides 3.9612224865 11605937
MESH:D011041 Poisoning Mustard Gas 3.2515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.9918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.042563599
MESH:D011225 Pre-Eclampsia Zinc 3.7017114810
MESH:D047928 Premature Birth Indomethacin 4.5417000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 13.0017184923
MESH:D011297 Prenatal Exposure Delayed Effects Lead 13.0016384672
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.0011118676 11896295 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2519131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2517292933
MESH:D011471 Prostatic Neoplasms Dicofol 2.2512584743
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.2515846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.2516740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.2516205645
MESH:D011471 Prostatic Neoplasms Thiram 2.2519789329
MESH:D011471 Prostatic Neoplasms Zinc 2.2512429649 16606632 16517595 16700911
MESH:D011507 Proteinuria Indomethacin 7.5011849393
MESH:D011507 Proteinuria Tretinoin 7.5016636307
MESH:D011537 Pruritus Ethinyl Estradiol 7.5415861022 16919318
MESH:D011537 Pruritus Mustard Gas 7.5418058305
MESH:D011565 Psoriasis Methotrexate 3.1917410198
MESH:D011595 Psychomotor Agitation Haloperidol 4.3711575062
MESH:D011618 Psychotic Disorders Clozapine 7.6715331141
MESH:D011618 Psychotic Disorders Haloperidol 7.6711575062
MESH:D011625 Pterygium Tretinoin 4.1916723453
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 4.7214606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.6717620002 17894541 10334151 17266442 17720292
MESH:D051437 Renal Insufficiency Methotrexate 4.1317352296
MESH:D015427 Reperfusion Injury Superoxides 4.2018460982
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.2618990726
MESH:D012162 Retinal Degeneration Zinc 3.6716584753
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.5419371211
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.1116849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5416116481 16283617
MESH:D012220 Rhinitis Acetaldehyde 4.2317050345
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.3916646077
MESH:D012559 Schizophrenia Clozapine 3.7018806925 20521326 20521320 18855531 11151749 20452607 20168265 20107430 17667964 11763009 19369910 17123785 17726453 16141801 20580759
MESH:D012559 Schizophrenia Haloperidol 3.7020107430 1830565 18513383 19369910
MESH:D012640 Seizures 2,6-dinitrotoluene 4.7118551238
MESH:D012640 Seizures Ethanol 4.719754883
MESH:D012852 Sinusitis Phenylephrine 4.107327846
MESH:D012871 Skin Diseases Ascorbic Acid 4.6518709164
MESH:D012871 Skin Diseases Mustard Gas 4.6516961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.5319755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.5312065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.5316192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.5311807781 18404319 8985016 12065085 8330346
MESH:D012878 Skin Neoplasms Tretinoin 14.5316467112
MESH:D013088 Spermatocele Diethylstilbestrol 9.6816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 9.6816709447
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.811977408
MESH:D013272 Stomach Diseases Indomethacin 3.8210192188 16113693 10215738 17207306 18209964 18545984 16184426 15472012 17638125 15038085 10486359 16280098 17160473
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.0217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.022093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.0218456281
MESH:D013274 Stomach Neoplasms Ethanol 9.0218456281
MESH:D013274 Stomach Neoplasms Indomethacin 9.0215609394
MESH:D013274 Stomach Neoplasms irinotecan 9.0215723263
MESH:D013274 Stomach Neoplasms Tretinoin 9.0217261132
MESH:D013276 Stomach Ulcer Ascorbic Acid 9.1818726076
MESH:D013276 Stomach Ulcer Ethanol 9.189211565 9562338 17918041 11906479 17189318 16755016
MESH:D013276 Stomach Ulcer Indomethacin 9.1818431645 11523592 10423059 18193104 16631530 18087811 17977527 12498302 16934674 10750652 16150113 12500499 10878458 15255614 11595431 16169175 15104355 18181030 16397915 18299717 15138204 18543354 12077510 17135157 18209962 11729361 17918041 11145282 1323529 17654042 11906479 18237397 17895592 12467913 17657623 11595415 14567935 12787963 18726076 17627676 16755016 16252198
MESH:D020521 Stroke Ascorbic Acid 3.8116517955 16403987
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.739754883
MESH:D013576 Syndactyly Methotrexate 4.469562676
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.1420210726
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.6415821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.0611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.2912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 13.3019014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.307505956
MESH:D013964 Thyroid Neoplasms Indomethacin 13.3018791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 13.3016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.0719048282
MESH:D014062 Tongue Neoplasms Tretinoin 8.2316051514
MESH:D014062 Tongue Neoplasms Zinc 8.2316543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.3615213294
MESH:D014202 Tremor Chlordecone 9.746175765
MESH:D014202 Tremor Lead 9.7421145352
MESH:D014376 Tuberculosis Tretinoin 2.8316040207
MESH:D014456 Ulcer Indomethacin 4.2917380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 9.6416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 9.6411780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.6417053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 9.6416452187 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7210091137
MESH:D014581 Urticaria Acetaminophen 2.4310982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 7.7616175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.7616129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.5614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.5815809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.5814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.0016752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8516002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.9812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0014671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.4916761959
MESH:D014839 Vomiting Indomethacin 4.1411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6315886252
MESH:D015430 Weight Gain Clozapine 3.9616141801 20107430 20521320 16402076 17502770 20564506
MESH:D015431 Weight Loss Clozapine 4.4817933447
MESH:D009396 Wilms Tumor Tretinoin 3.4516287080
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:05146 Amoebiasis
KEGG:04662 B cell receptor signaling pathway
KEGG:04020 Calcium signaling pathway
KEGG:04973 Carbohydrate digestion and absorption
KEGG:04062 Chemokine signaling pathway
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
KEGG:04012 ErbB signaling pathway
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04666 Fc gamma R-mediated phagocytosis
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:05214 Glioma
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:604 Hemostasis
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04010 MAPK signaling pathway
KEGG:04916 Melanogenesis
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:05223 Non-small cell lung cancer
KEGG:04972 Pancreatic secretion
KEGG:05200 Pathways in cancer
KEGG:04070 Phosphatidylinositol signaling system
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
KEGG:04530 Tight junction
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
KEGG:05110 Vibrio cholerae infection
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33761
    • No data
    Releated disease ID Related disease Name
    PA128406954Weight gain
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445062Neoplasms
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA10026aripiprazole
    PA449061clozapine
    PA450688olanzapine
    PA451201quetiapine
    PA451257risperidone
    PA451620teriparatide
    PA449748gemcitabine
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00163 - Vitamin E Dietary supplement;Micronutrient;Antioxidants;Vitamins/minerals;Vitamins
    DB01738 - O-Phosphoethanolamine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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