AutismKB 2.0

Annotation Detail for CSGALNACT1


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Basic Information Top
Gene Symbol:CSGALNACT1 ( CSGalNAcT-1,ChGn,FLJ11264,FLJ13760,beta4GalNAcT )
Gene Full Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Band: 8p21.3
Quick LinksEntrez ID:55790; OMIM: NA; Uniprot ID:CGAT1_HUMAN; ENSEMBL ID: ENSG00000147408; HGNC ID: 24290
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6567chondroitin sulfate biosynthesis (late stages)
PWY-6566chondroitin and dermatan biosynthesis
PWY-6569chondroitin sulfate biosynthesis
PWY-6571dermatan sulfate biosynthesis
Pathway IDPathway Name
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of CSGALNACT1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CSGALNACT1 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of CSGALNACT1 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CSGALNACT1 mRNAdecreases expression 19150397
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of CSGALNACT1 mRNAincreases expression 17005392
D005047 Etoposide CSGALNACT1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of CSGALNACT1 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.249612607
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5719825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5720127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8615469931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.6814601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0420146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0417129689 15324884
MESH:D001943 Breast Neoplasms Etoposide 2.0416322251
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.3314691202 16217749 15073043 11135700 15553829
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.3316924424 15948411
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.9412952375 16002989
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D004362 Drug Toxicity Zidovudine 4.2315040536
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 5.1616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.6615700306 16804899
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.6012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6016530937
MESH:D005234 Fatty Liver arsenic trioxide 9.2415073043
MESH:D005234 Fatty Liver Zidovudine 9.2418299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8316002989 16513791 15751030 16611131 16534752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.4116452187
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006402 Hematologic Diseases Zidovudine 5.0612579204
MESH:D006561 Herpes Simplex Etoposide 5.0210809021
MESH:D015658 HIV Infections Zidovudine 3.6311141242 11363243 17358032 11698656 20032539
MESH:D006689 Hodgkin Disease Etoposide 4.1515147373 16135485 16200630 17606976 18180244
MESH:D006965 Hyperplasia Diethylstilbestrol 4.8514722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 5.0016002989
MESH:D007246 Infertility Diethylstilbestrol 4.7415036965
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.7416762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Zidovudine 8.7412579204
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4817184923
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.9512560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.9520370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 19850784 20471514 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4117107899 12018890 11468182 17217047 17712046 19225113 19642359 16966277 19075265 17869043 16112521 11161223 12712474 16891316 16330433 15622746 15748426 17649720 16331271 15213294 15336539 16823087 19035177 12679006 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008113 Liver Neoplasms arsenic trioxide 8.0914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0920195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 8.0915890375 16712894
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6811798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6818520028 18816296 20064080 18569708 6695378 20464547 20135361 20869020 17053015
MESH:D008175 Lung Neoplasms Zidovudine 3.6818800350
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.6115166399
MESH:D008223 Lymphoma Diethylstilbestrol 8.6515700306
MESH:D008223 Lymphoma Etoposide 8.6512556972 12854902
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 6.0416002989
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.3617358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3211468182 19549372 14977855 19417148 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5811141357
MESH:D009369 Neoplasms Diethylstilbestrol 5.5815313581
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.5211399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3110525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4819769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.9015580305
MESH:D010190 Pancreatic Neoplasms Etoposide 5.9019003803
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0915687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.5717184923
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Etoposide 2.0817172428
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 11.7516646077
MESH:D012512 Sarcoma, Ewing's Etoposide 11.7514601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013088 Spermatocele Diethylstilbestrol 5.2316709447 16002989
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.562093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 3.5617696246
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9720435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9717053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.9716452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.4515809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 12.5716513791 16002989
MESH:D014625 Vaginal Neoplasms Zidovudine 12.5712579204
Pathway ID Pathway Name
KEGG:00532 Glycosaminoglycan biosynthesis - chondroitin sulfate
KEGG:01100 Metabolic pathways
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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