AutismKB 2.0

Annotation Detail for CACNA2D3


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Basic Information Top
Gene Symbol:CACNA2D3 ( HSA272268 )
Gene Full Name: calcium channel, voltage-dependent, alpha 2/delta subunit 3
Band: 3p21.1-p14.3
Quick LinksEntrez ID:55799; OMIM: 606399; Uniprot ID:CA2D3_HUMAN; ENSEMBL ID: ENSG00000157445; HGNC ID: 15460
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Synaptic Transmission
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CACNA2D3 mRNAaffects expression 16483693
D007052 Ibuprofen Ibuprofen affects the expression of CACNA2D3 mRNAaffects expression 17070997
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of CACNA2D3 mRNAdecreases expression 15585362
C116926 rofecoxib rofecoxib results in decreased expression of CACNA2D3 mRNAdecreases expression 17070997
D018038 Sodium Selenite Sodium Selenite results in increased expression of CACNA2D3 mRNAincreases expression 18175754
C025643 vinclozolin vinclozolin affects the expression of CACNA2D3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D058186 Acute Kidney Injury Ibuprofen 4.776375363
MESH:D000230 Adenocarcinoma Ibuprofen 3.3110697514
MESH:D000544 Alzheimer Disease Ibuprofen 3.2218351690
MESH:D000707 Anaphylaxis Ibuprofen 5.669532969
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001169 Arthritis, Experimental rofecoxib 4.5216690336
MESH:D002545 Brain Ischemia Ibuprofen 5.3415837124
MESH:D002100 Cachexia Ibuprofen 5.9315141370
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003110 Colonic Neoplasms rofecoxib 3.3412902858
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.3515131321
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 6.0818450898 18446180 16133044
MESH:D004715 Endometriosis Ibuprofen 10.9515652904
MESH:D004715 Endometriosis rofecoxib 10.9515652904
MESH:D019446 Endotoxemia Ibuprofen 5.4311545620
MESH:D005334 Fever Ibuprofen 4.8916997862
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006984 Hypertrophy Ibuprofen 5.3016672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 6.3616133044
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007249 Inflammation Ibuprofen 3.583291741
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007410 Intestinal Diseases rofecoxib 5.4515831440
MESH:D007417 Intestinal Polyps rofecoxib 5.7211245490
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 3.0817565644
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 3.8910697514
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.506375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.6310961664
MESH:D010003 Osteoarthritis Ibuprofen 8.887009135
MESH:D010003 Osteoarthritis rofecoxib 8.8816690336
MESH:D010146 Pain Ibuprofen 4.193291741
MESH:D010149 Pain, Postoperative Ibuprofen 13.5416678543
MESH:D010149 Pain, Postoperative rofecoxib 13.5418165598 16678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 3.5712384795
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Ibuprofen 3.6217409433
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.6218760546
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011507 Proteinuria Ibuprofen 4.986375363
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.6519057314
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
KEGG:04010 MAPK signaling pathway
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00381 antagonist Lotrel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Antianginals
DB06712 antagonist Nilvadipine Antihypertensive Agents;Calcium Channel Blockers
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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